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Article: Fibrinogen, other cardiovascular risk factors and diabetes mellitus in Hong Kong: A community with high prevalence of Type 2 diabetes mellitus and impaired glucose tolerance

TitleFibrinogen, other cardiovascular risk factors and diabetes mellitus in Hong Kong: A community with high prevalence of Type 2 diabetes mellitus and impaired glucose tolerance
Authors
KeywordsChinese
Fibrinogen
Hong Kong
Hypertension
Obesity
Type 2 diabetes mellitus
Issue Date2000
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DME
Citation
Diabetic Medicine, 2000, v. 17 n. 11, p. 798-806 How to Cite?
AbstractAims To determine the prevalence of Type 2 diabetes mellitus and impaired glucose tolerance (IGT) and their relationships to fibrinogen and other cardiovascular risk factors in Hong Kong Chinese. Methods A probability sample of 1316 men and 1348 women aged 25-74 years were examined in a population-based cross-sectional study. Results: A total of 3.0% (95% confidence interval 2.1-3.9) of men had previously diagnosed (known) and 6.4% (5.0-7.8) newly diagnosed (unknown) diabetes, 14.4% (12.4-16.5) had IGT and 79.2% were normal by 1985 WHO diagnostic criteria; corresponding prevalences in women were 3.7% (2.7-4.7), 5.9% (4.6-7.2), 17% (14.8-19.2) and 73.4%. The age-standardized prevalence of Type 2 diabetes for the 35-64 age group was 9.5% (7.5-11.6) in men and 10.2% (8.0-12.4) in women. Age-adjusted mean fibrinogen levels in these four groups (normal/IGT/unknown diabetes/known diabetes) with decreasing degrees of glucose tolerance (diabetes status) were 2.80, 2.57, 2.51 and 2.47 g/l (P = 0.003) in men, and 2.86, 2.72, 2.67, 2.61 g/l (P = 0.005) in women. Age, obesity, systolic blood pressure and triglycerides were significantly associated with diabetes status in both sexes, fibrinogen in men only and high density lipoprotein cholesterol negatively in women. Conclusions: The prevalence of Type 2 diabetes mellitus was very high especially in older subjects, and fibrinogen was associated with increasing glucose intolerance in men but not in women, The detection and better control of cardiovascular risk factors, particularly hypertension in this developed Chinese community with a high prevalence of diabetes and glucose intolerance, is particularly important.
Persistent Identifierhttp://hdl.handle.net/10722/86956
ISSN
2015 Impact Factor: 3.152
2015 SCImago Journal Rankings: 1.654
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, THen_HK
dc.contributor.authorLiu, LJen_HK
dc.contributor.authorJanus, EDen_HK
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorHedley, AJen_HK
dc.date.accessioned2010-09-06T09:23:24Z-
dc.date.available2010-09-06T09:23:24Z-
dc.date.issued2000en_HK
dc.identifier.citationDiabetic Medicine, 2000, v. 17 n. 11, p. 798-806en_HK
dc.identifier.issn0742-3071en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86956-
dc.description.abstractAims To determine the prevalence of Type 2 diabetes mellitus and impaired glucose tolerance (IGT) and their relationships to fibrinogen and other cardiovascular risk factors in Hong Kong Chinese. Methods A probability sample of 1316 men and 1348 women aged 25-74 years were examined in a population-based cross-sectional study. Results: A total of 3.0% (95% confidence interval 2.1-3.9) of men had previously diagnosed (known) and 6.4% (5.0-7.8) newly diagnosed (unknown) diabetes, 14.4% (12.4-16.5) had IGT and 79.2% were normal by 1985 WHO diagnostic criteria; corresponding prevalences in women were 3.7% (2.7-4.7), 5.9% (4.6-7.2), 17% (14.8-19.2) and 73.4%. The age-standardized prevalence of Type 2 diabetes for the 35-64 age group was 9.5% (7.5-11.6) in men and 10.2% (8.0-12.4) in women. Age-adjusted mean fibrinogen levels in these four groups (normal/IGT/unknown diabetes/known diabetes) with decreasing degrees of glucose tolerance (diabetes status) were 2.80, 2.57, 2.51 and 2.47 g/l (P = 0.003) in men, and 2.86, 2.72, 2.67, 2.61 g/l (P = 0.005) in women. Age, obesity, systolic blood pressure and triglycerides were significantly associated with diabetes status in both sexes, fibrinogen in men only and high density lipoprotein cholesterol negatively in women. Conclusions: The prevalence of Type 2 diabetes mellitus was very high especially in older subjects, and fibrinogen was associated with increasing glucose intolerance in men but not in women, The detection and better control of cardiovascular risk factors, particularly hypertension in this developed Chinese community with a high prevalence of diabetes and glucose intolerance, is particularly important.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DMEen_HK
dc.relation.ispartofDiabetic Medicineen_HK
dc.rightsDiabetic Medicine. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectChineseen_HK
dc.subjectFibrinogenen_HK
dc.subjectHong Kongen_HK
dc.subjectHypertensionen_HK
dc.subjectObesityen_HK
dc.subjectType 2 diabetes mellitusen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAsian Continental Ancestry Groupen_HK
dc.subject.meshBlood Pressureen_HK
dc.subject.meshCardiovascular Diseases - epidemiologyen_HK
dc.subject.meshCholesterol, HDL - blooden_HK
dc.subject.meshConfidence Intervalsen_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshDiabetes Mellitus, Type 2 - epidemiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFibrinogen - analysisen_HK
dc.subject.meshGlucose Intolerance - epidemiologyen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypertension - epidemiologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshObesity - epidemiologyen_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSex Factorsen_HK
dc.subject.meshTriglycerides - blooden_HK
dc.titleFibrinogen, other cardiovascular risk factors and diabetes mellitus in Hong Kong: A community with high prevalence of Type 2 diabetes mellitus and impaired glucose toleranceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0742-3071&volume=17&spage=798&epage=806&date=2001&atitle=Fibrinogen,+other+cardiovascular+risk+factors+and+diabetes+mellitus+in+Hong+Kong:+a+community+with+high+prevalence+of+Type+2+diabetes+mellitus+and+impaired+glucose+toleranceen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.emailHedley, AJ:hrmrajh@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.authorityHedley, AJ=rp00357en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1464-5491.2000.00384.xen_HK
dc.identifier.pmid11131105-
dc.identifier.scopuseid_2-s2.0-0034534774en_HK
dc.identifier.hkuros56261en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034534774&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue11en_HK
dc.identifier.spage798en_HK
dc.identifier.epage806en_HK
dc.identifier.isiWOS:000165702200007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridLiu, LJ=21737444900en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridHedley, AJ=7102584095en_HK

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