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Article: Central obesity predicts the worsening of glycemia in southern Chinese

TitleCentral obesity predicts the worsening of glycemia in southern Chinese
Authors
KeywordsCentral obesity
Chinese
Diabetes mellitus
Impaired glucose tolerance
Issue Date2001
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ijo/
Citation
International Journal Of Obesity, 2001, v. 25 n. 12, p. 1789-1793 How to Cite?
AbstractAIMS: The association between obesity and type 2 diabetes has been found to be consistent across different ethnic populations. Our aim was to study the contribution of obesity to the development of type 2 diabetes in a non-obese Chinese population with a high prevalence of diabetes (9.8% in 1995-1996). METHODS: Six-hundred and forty-four non-diabetic subjects were recruited from the Hong Kong Cardiovascular Risk Factor Prevalence Study (1995-1996). This was a community-based population study which involved the use of a 75 g oral glucose tolerance test and 1985 World Health Organization diagnostic criteria. Their glycemic status was reassessed at 2y. RESULTS: In subjects with impaired glucose tolerance (n = 322), the annual progression rate to diabetes (4.8%; 95% Cl 2.57.1%), was 8-fold that in control subjects (0.6%; 95% Cl 0.0-1.4%; P ≤ 0.001). Baseline waist-hip ratio (WHR; OR per unit increase = 1.05; 95% Cl 1.02-1.07, P = 0.0003) and post-load 2 h plasma glucose (OR per unit increase = 2.02; 95% Cl 1.762.34, P ≤ 0.0001) were significantly associated with glycemic status at 2y in stepwise polytomous logistic regression analysis. Subjects with high baseline waist circumference or WHR (≥ median) were more likely to have worsening of glucose tolerance at 2y than those with low waist circumference (≤ median; conversion to diabetes, OR 3.8, P = O.001) or WHR (≤ median; conversion to diabetes, OR 2.8, P = 0.019). CONCLUSION: Abdominal obesity, readily assessed by the measurement of WHR or waist circumference, was for the first time shown prospectively to be independently associated with the deterioration of glucose tolerance in a Chinese population.
Persistent Identifierhttp://hdl.handle.net/10722/86863
ISSN
2015 Impact Factor: 5.337
2015 SCImago Journal Rankings: 2.752
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorJanus, EDen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-09-06T09:22:15Z-
dc.date.available2010-09-06T09:22:15Z-
dc.date.issued2001en_HK
dc.identifier.citationInternational Journal Of Obesity, 2001, v. 25 n. 12, p. 1789-1793en_HK
dc.identifier.issn0307-0565en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86863-
dc.description.abstractAIMS: The association between obesity and type 2 diabetes has been found to be consistent across different ethnic populations. Our aim was to study the contribution of obesity to the development of type 2 diabetes in a non-obese Chinese population with a high prevalence of diabetes (9.8% in 1995-1996). METHODS: Six-hundred and forty-four non-diabetic subjects were recruited from the Hong Kong Cardiovascular Risk Factor Prevalence Study (1995-1996). This was a community-based population study which involved the use of a 75 g oral glucose tolerance test and 1985 World Health Organization diagnostic criteria. Their glycemic status was reassessed at 2y. RESULTS: In subjects with impaired glucose tolerance (n = 322), the annual progression rate to diabetes (4.8%; 95% Cl 2.57.1%), was 8-fold that in control subjects (0.6%; 95% Cl 0.0-1.4%; P ≤ 0.001). Baseline waist-hip ratio (WHR; OR per unit increase = 1.05; 95% Cl 1.02-1.07, P = 0.0003) and post-load 2 h plasma glucose (OR per unit increase = 2.02; 95% Cl 1.762.34, P ≤ 0.0001) were significantly associated with glycemic status at 2y in stepwise polytomous logistic regression analysis. Subjects with high baseline waist circumference or WHR (≥ median) were more likely to have worsening of glucose tolerance at 2y than those with low waist circumference (≤ median; conversion to diabetes, OR 3.8, P = O.001) or WHR (≤ median; conversion to diabetes, OR 2.8, P = 0.019). CONCLUSION: Abdominal obesity, readily assessed by the measurement of WHR or waist circumference, was for the first time shown prospectively to be independently associated with the deterioration of glucose tolerance in a Chinese population.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ijo/en_HK
dc.relation.ispartofInternational Journal of Obesityen_HK
dc.subjectCentral obesityen_HK
dc.subjectChineseen_HK
dc.subjectDiabetes mellitusen_HK
dc.subjectImpaired glucose toleranceen_HK
dc.subject.meshAbdomenen_HK
dc.subject.meshAdipose Tissue - anatomy & histologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshBlood Glucose - metabolismen_HK
dc.subject.meshBody Constitutionen_HK
dc.subject.meshChina - epidemiologyen_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshDiabetes Mellitus - epidemiology - metabolismen_HK
dc.subject.meshDiabetes Mellitus, Type 2 - epidemiology - metabolism - physiopathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGlucose Intoleranceen_HK
dc.subject.meshGlucose Tolerance Testen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshObesity - epidemiology - etiology - metabolismen_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshProspective Studiesen_HK
dc.titleCentral obesity predicts the worsening of glycemia in southern Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0307-0565&volume=25&spage=1789&epage=93&date=2001&atitle=Central+obesity+predicts+the+worsening+of+glycemia+in+southern+Chineseen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/sj.ijo.0801834en_HK
dc.identifier.pmid11781759-
dc.identifier.scopuseid_2-s2.0-0035214382en_HK
dc.identifier.hkuros74379en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035214382&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1789en_HK
dc.identifier.epage1793en_HK
dc.identifier.isiWOS:000172478300007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWat, NMS=6602131754en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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