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Article: Spatial considerations for the allocation of pre-pandemic influenza vaccination in the United States

TitleSpatial considerations for the allocation of pre-pandemic influenza vaccination in the United States
Authors
Issue Date2007
PublisherThe Royal Society. The Journal's web site is located at http://www.pubs.royalsoc.ac.uk/index.cfm?page=1087
Citation
Proceedings Of The Royal Society B: Biological Sciences, 2007, v. 274 n. 1627, p. 2811-2817 How to Cite?
AbstractThe impact of the next influenza pandemic may be mitigated by inducing immunity in individuals prior to the start of national epidemics using a pre-pandemic vaccine targeted against current avian influenza strains. The US Department of Health and Human Services (HHS) intends that pre-pandemic vaccines will be allocated to states in proportion to the size of their population in predefined priority groups, i.e. approximately pro-rata. We show that such an equitable policy is likely to be the least efficient in terms of the number of infections averted. We demonstrate that the potential benefits could be substantial if a fully discretionary policy is allowed, i.e. if some regions are allocated sufficient vaccines to achieve herd immunity while other regions are allocated no vaccine. Since such an inequitable policy may be impractical, we consider the sensitivity of an intermediate policy (in which 50% of the stockpile is allocated on a pro-rata basis) to key transmission uncertainties. The benefits of the 50% discretionary policy are sensitive to parameter values which cannot be known in advance. Therefore, despite substantial potential benefits of non-pro-rata policies, our results suggest that the current HHS policy of pro-rata allocation by state is a good compromise in terms of simplicity, robustness, equity and efficiency. © 2007 The Royal Society.
Persistent Identifierhttp://hdl.handle.net/10722/86756
ISSN
2014 Impact Factor: 5.051
2014 SCImago Journal Rankings: 2.172
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, JTen_HK
dc.contributor.authorRiley, Sen_HK
dc.contributor.authorLeung, GMen_HK
dc.date.accessioned2010-09-06T09:20:56Z-
dc.date.available2010-09-06T09:20:56Z-
dc.date.issued2007en_HK
dc.identifier.citationProceedings Of The Royal Society B: Biological Sciences, 2007, v. 274 n. 1627, p. 2811-2817en_HK
dc.identifier.issn0962-8452en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86756-
dc.description.abstractThe impact of the next influenza pandemic may be mitigated by inducing immunity in individuals prior to the start of national epidemics using a pre-pandemic vaccine targeted against current avian influenza strains. The US Department of Health and Human Services (HHS) intends that pre-pandemic vaccines will be allocated to states in proportion to the size of their population in predefined priority groups, i.e. approximately pro-rata. We show that such an equitable policy is likely to be the least efficient in terms of the number of infections averted. We demonstrate that the potential benefits could be substantial if a fully discretionary policy is allowed, i.e. if some regions are allocated sufficient vaccines to achieve herd immunity while other regions are allocated no vaccine. Since such an inequitable policy may be impractical, we consider the sensitivity of an intermediate policy (in which 50% of the stockpile is allocated on a pro-rata basis) to key transmission uncertainties. The benefits of the 50% discretionary policy are sensitive to parameter values which cannot be known in advance. Therefore, despite substantial potential benefits of non-pro-rata policies, our results suggest that the current HHS policy of pro-rata allocation by state is a good compromise in terms of simplicity, robustness, equity and efficiency. © 2007 The Royal Society.en_HK
dc.languageengen_HK
dc.publisherThe Royal Society. The Journal's web site is located at http://www.pubs.royalsoc.ac.uk/index.cfm?page=1087en_HK
dc.relation.ispartofProceedings of the Royal Society B: Biological Sciencesen_HK
dc.subject.meshDisease Outbreaks - prevention & controlen_HK
dc.subject.meshHealth Policyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunization Programsen_HK
dc.subject.meshInfluenza Vaccinesen_HK
dc.subject.meshInfluenza, Human - prevention & controlen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshUnited Statesen_HK
dc.subject.meshUnited States Dept. of Health and Human Servicesen_HK
dc.titleSpatial considerations for the allocation of pre-pandemic influenza vaccination in the United Statesen_HK
dc.typeArticleen_HK
dc.identifier.emailWu, JT:joewu@hkucc.hku.hken_HK
dc.identifier.emailRiley, S:sriley@hkucc.hku.hk, steven.riley@hku.hken_HK
dc.identifier.emailLeung, GM:gmleung@hku.hken_HK
dc.identifier.authorityWu, JT=rp00517en_HK
dc.identifier.authorityRiley, S=rp00511en_HK
dc.identifier.authorityLeung, GM=rp00460en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1098/rspb.2007.0893en_HK
dc.identifier.pmid17785273en_HK
dc.identifier.scopuseid_2-s2.0-35848959760en_HK
dc.identifier.hkuros139415en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35848959760&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume274en_HK
dc.identifier.issue1627en_HK
dc.identifier.spage2811en_HK
dc.identifier.epage2817en_HK
dc.identifier.isiWOS:000250555000005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWu, JT=7409256423en_HK
dc.identifier.scopusauthoridRiley, S=7102619416en_HK
dc.identifier.scopusauthoridLeung, GM=7007159841en_HK
dc.identifier.citeulike9564313-

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