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Article: Relationship between the metabolic syndrome and the development of hypertension in the Hong Kong cardiovascular risk factor prevalence study-2 (CRISPS2)

TitleRelationship between the metabolic syndrome and the development of hypertension in the Hong Kong cardiovascular risk factor prevalence study-2 (CRISPS2)
Authors
Issue Date2008
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjhyper
Citation
American Journal Of Hypertension, 2008, v. 21 n. 1, p. 17-22 How to Cite?
AbstractBackground: The metabolic syndrome is a predictor of diabetes and coronary events. We hypothesized that it also predicts hypertension. Methods: A total of 1,944 subjects (901 men and 1,043 women; age 46 ± 12 years) from the Hong Kong Cardiovascular Risk Factor Prevalence Survey were recruited in 1995-1996 and restudied in 2000-2004. The prevalence of hypertension and factors predicting its development were determined. Results: In 2000-2004, hypertension was found in 23.2% of the men and 17.2% of the women. Of the 1,602 subjects who were normotensive at baseline, 258 subjects developed hypertension after a median interval of 6.4 years. According to the National Cholesterol Education Program (NCEP) and International Diabetes Federation (IDF) criteria, the hazard ratios associated with the metabolic syndrome were 1.89 (95% confidence interval (CI): 1.41-2.54) and 1.72 (95% CI: 1.24-2.39), respectively. The positive and negative predictive values of the metabolic syndrome for identifying subjects who will develop hypertension in this population were 34.7 and 85.4% (NCEP criteria), and 33.1 and 85.5% (IDF criteria), respectively. The development of hypertension was related to the number of components of the metabolic syndrome (other than raised blood pressure), present in men (P = 0.003) and in women (P = 0.001). Using multivariate analysis, age, baseline systolic blood pressure (SBP), body mass index (BMI), and the triglycerides/high-density lipoprotein (HDL) ratio were found to be significant predictors of the development of hypertension. Compared with optimal blood pressure, the hazards of developing hypertension associated with normal or high-normal blood pressure were 2.31 (95% CI: 1.68-3.17) and 3.48 (95% CI: 2.52-4.81), respectively. Conclusions: Blood pressure, when not optimal, is the predominant predictor of hypertension. The metabolic syndrome contributes to the risk, especially when blood pressure is optimal. © 2008 American Journal of Hypertension, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/86486
ISSN
2015 Impact Factor: 3.182
2015 SCImago Journal Rankings: 1.397
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorMan, YBen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorCheng, CHen_HK
dc.contributor.authorLeung, GMen_HK
dc.contributor.authorWoo, Jen_HK
dc.contributor.authorJanus, EDen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-09-06T09:17:39Z-
dc.date.available2010-09-06T09:17:39Z-
dc.date.issued2008en_HK
dc.identifier.citationAmerican Journal Of Hypertension, 2008, v. 21 n. 1, p. 17-22en_HK
dc.identifier.issn0895-7061en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86486-
dc.description.abstractBackground: The metabolic syndrome is a predictor of diabetes and coronary events. We hypothesized that it also predicts hypertension. Methods: A total of 1,944 subjects (901 men and 1,043 women; age 46 ± 12 years) from the Hong Kong Cardiovascular Risk Factor Prevalence Survey were recruited in 1995-1996 and restudied in 2000-2004. The prevalence of hypertension and factors predicting its development were determined. Results: In 2000-2004, hypertension was found in 23.2% of the men and 17.2% of the women. Of the 1,602 subjects who were normotensive at baseline, 258 subjects developed hypertension after a median interval of 6.4 years. According to the National Cholesterol Education Program (NCEP) and International Diabetes Federation (IDF) criteria, the hazard ratios associated with the metabolic syndrome were 1.89 (95% confidence interval (CI): 1.41-2.54) and 1.72 (95% CI: 1.24-2.39), respectively. The positive and negative predictive values of the metabolic syndrome for identifying subjects who will develop hypertension in this population were 34.7 and 85.4% (NCEP criteria), and 33.1 and 85.5% (IDF criteria), respectively. The development of hypertension was related to the number of components of the metabolic syndrome (other than raised blood pressure), present in men (P = 0.003) and in women (P = 0.001). Using multivariate analysis, age, baseline systolic blood pressure (SBP), body mass index (BMI), and the triglycerides/high-density lipoprotein (HDL) ratio were found to be significant predictors of the development of hypertension. Compared with optimal blood pressure, the hazards of developing hypertension associated with normal or high-normal blood pressure were 2.31 (95% CI: 1.68-3.17) and 3.48 (95% CI: 2.52-4.81), respectively. Conclusions: Blood pressure, when not optimal, is the predominant predictor of hypertension. The metabolic syndrome contributes to the risk, especially when blood pressure is optimal. © 2008 American Journal of Hypertension, Ltd.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjhyperen_HK
dc.relation.ispartofAmerican Journal of Hypertensionen_HK
dc.subject.meshAdult-
dc.subject.meshAge Factors-
dc.subject.meshCardiovascular Diseases - blood - epidemiology - etiology - physiopathology-
dc.subject.meshHypertension - blood - complications - epidemiology - etiology - physiopathology-
dc.subject.meshMetabolic Syndrome X - blood - complications - epidemiology - physiopathology-
dc.titleRelationship between the metabolic syndrome and the development of hypertension in the Hong Kong cardiovascular risk factor prevalence study-2 (CRISPS2)en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0895-7061&volume=21&issue=1&spage=17&epage=22&date=2008&atitle=Relationship+between+the+metabolic+syndrome+and+the+development+of+hypertension+in+the+Hong+Kong+Cardiovascular+Risk+Factor+Prevalence+Study-2+(CRISPS2)en_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.emailLeung, GM:gmleung@hku.hken_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityLeung, GM=rp00460en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ajh.2007.19en_HK
dc.identifier.pmid18091739-
dc.identifier.scopuseid_2-s2.0-38349150081en_HK
dc.identifier.hkuros142078en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38349150081&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue1en_HK
dc.identifier.spage17en_HK
dc.identifier.epage22en_HK
dc.identifier.isiWOS:000251938200012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridWat, NMS=6602131754en_HK
dc.identifier.scopusauthoridMan, YB=10245005900en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridCheng, CH=37053188100en_HK
dc.identifier.scopusauthoridLeung, GM=7007159841en_HK
dc.identifier.scopusauthoridWoo, J=36040369400en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.citeulike2259965-

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