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Article: Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: A prognostic marker of human esophageal squamous cell carcinomas

TitleHepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: A prognostic marker of human esophageal squamous cell carcinomas
Authors
Issue Date2005
PublisherAmerican Association for Cancer Research.
Citation
Clinical Cancer Research, 2005, v. 11 n. 17, p. 6190-6197 How to Cite?
AbstractPurpose: Hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, c-Met, play important roles in tumor development and progression. In this study, we measured the serum HGF levels in patients with esophageal squamous cell carcinoma (ESCC) to evaluate its relationships with clinicopathologic features and the role of HGF in ESCC. Experimental Design: One hundred and forty-nine patients with ESCC were studied. Pretherapy serum was collected and ELISA was used to detect the concentrations of HGF, vascular endothelial growth factor (VEGF), and interleukin 8 (IL-8). The function of HGF was shown by invasion chamber assay. Results: Pretherapy serum HGF was found to be significantly higher in patients with ESCC than in control subjects. The levels of HGF correlated significantly with advanced tumor metastasis stage and survival. Multivariate analyses showed that serum HGF level in cell migration was an independent prognostic factor. Increased HGF serum levels correlated positively with serum levels of VEGF and IL-8. Our results also showed that HGF was overexpressed in ESCC tissues and cell lines. In vitro study showed that HGF could stimulate ESCC cell to express VEGF and IL-8 and markedly enhance invasion and migration of ESCC cells. Furthermore, HGF-induced IL-8 and VEGF expression was dependent on extracellular signal-regulated kinase signaling pathways. The inhibition of extracellular signal-regulated kinase activation reduced HGF-mediated IL-8 and VEGF expression. Conclusions: Our results suggest that serum HGF may be a useful biomarker of tumor progression and a valuable independent prognostic factor in patients with ESCC. HGF may be involved in the progression of ESCC as an autocrine/paracrine factor via enhancing angiogenesis and tumor cell invasion and migration. © 2005 American Association for Cancer Research.
Persistent Identifierhttp://hdl.handle.net/10722/84558
ISSN
2015 Impact Factor: 8.738
2015 SCImago Journal Rankings: 5.314
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRen, Yen_HK
dc.contributor.authorCao, Ben_HK
dc.contributor.authorLaw, Sen_HK
dc.contributor.authorXie, Yen_HK
dc.contributor.authorLee, PYen_HK
dc.contributor.authorCheung, Len_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorHuang, Xen_HK
dc.contributor.authorChan, HMen_HK
dc.contributor.authorZhao, Pen_HK
dc.contributor.authorLuk, Jen_HK
dc.contributor.authorVande Woude, Gen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T08:54:22Z-
dc.date.available2010-09-06T08:54:22Z-
dc.date.issued2005en_HK
dc.identifier.citationClinical Cancer Research, 2005, v. 11 n. 17, p. 6190-6197en_HK
dc.identifier.issn1078-0432en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84558-
dc.description.abstractPurpose: Hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, c-Met, play important roles in tumor development and progression. In this study, we measured the serum HGF levels in patients with esophageal squamous cell carcinoma (ESCC) to evaluate its relationships with clinicopathologic features and the role of HGF in ESCC. Experimental Design: One hundred and forty-nine patients with ESCC were studied. Pretherapy serum was collected and ELISA was used to detect the concentrations of HGF, vascular endothelial growth factor (VEGF), and interleukin 8 (IL-8). The function of HGF was shown by invasion chamber assay. Results: Pretherapy serum HGF was found to be significantly higher in patients with ESCC than in control subjects. The levels of HGF correlated significantly with advanced tumor metastasis stage and survival. Multivariate analyses showed that serum HGF level in cell migration was an independent prognostic factor. Increased HGF serum levels correlated positively with serum levels of VEGF and IL-8. Our results also showed that HGF was overexpressed in ESCC tissues and cell lines. In vitro study showed that HGF could stimulate ESCC cell to express VEGF and IL-8 and markedly enhance invasion and migration of ESCC cells. Furthermore, HGF-induced IL-8 and VEGF expression was dependent on extracellular signal-regulated kinase signaling pathways. The inhibition of extracellular signal-regulated kinase activation reduced HGF-mediated IL-8 and VEGF expression. Conclusions: Our results suggest that serum HGF may be a useful biomarker of tumor progression and a valuable independent prognostic factor in patients with ESCC. HGF may be involved in the progression of ESCC as an autocrine/paracrine factor via enhancing angiogenesis and tumor cell invasion and migration. © 2005 American Association for Cancer Research.en_HK
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research.en_HK
dc.relation.ispartofClinical Cancer Researchen_HK
dc.titleHepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: A prognostic marker of human esophageal squamous cell carcinomasen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1078-0432&volume=11&issue=17&spage=6190&epage=6197&date=2005&atitle=Hepatocyte+growth+factor+promotes+cancer+cell+migration+and+angiogenic+factors+expression:+a+prognostic+marker+of+human+esophageal+squamous+cell+carcinomasen_HK
dc.identifier.emailLaw, S: slaw@hku.hken_HK
dc.identifier.emailLuk, J: jmluk@hkucc.hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityLaw, S=rp00437en_HK
dc.identifier.authorityLuk, J=rp00349en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1158/1078-0432.CCR-04-2553en_HK
dc.identifier.pmid16144920-
dc.identifier.scopuseid_2-s2.0-24344452432en_HK
dc.identifier.hkuros114534en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-24344452432&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue17en_HK
dc.identifier.spage6190en_HK
dc.identifier.epage6197en_HK
dc.identifier.isiWOS:000231723600015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridRen, Y=8109150500en_HK
dc.identifier.scopusauthoridCao, B=7102832645en_HK
dc.identifier.scopusauthoridLaw, S=7202241293en_HK
dc.identifier.scopusauthoridXie, Y=7403958906en_HK
dc.identifier.scopusauthoridLee, PY=8731985700en_HK
dc.identifier.scopusauthoridCheung, L=21740536900en_HK
dc.identifier.scopusauthoridChen, Y=8731985900en_HK
dc.identifier.scopusauthoridHuang, X=55212099100en_HK
dc.identifier.scopusauthoridChan, HM=7403402552en_HK
dc.identifier.scopusauthoridZhao, P=34882364900en_HK
dc.identifier.scopusauthoridLuk, J=7006777791en_HK
dc.identifier.scopusauthoridVande Woude, G=7103031991en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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