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Article: Malignant melanoma of the oesophagus: Clinicopathological features, lack of p53 expression and steroid receptors and a review of the literature

TitleMalignant melanoma of the oesophagus: Clinicopathological features, lack of p53 expression and steroid receptors and a review of the literature
Authors
KeywordsChinese
Incidence
Melanoma
Oesophagus
p53
Steroid receptor
Issue Date1999
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejso
Citation
European Journal Of Surgical Oncology, 1999, v. 25 n. 2, p. 168-172 How to Cite?
AbstractAims: Fortunately, primary malignant melanoma of the oesophagus is a rare entity. The aims of this study were to evaluate the clinicopathological features, p53 over-expression and steroid receptors in oesophageal melanomas and to review the reported cases in the literature. Methods: Melanomas reported during a 15-year period (1982-1996) in the Queen Mary Hospital were studied. The clinicopathological features and survival data of patients with oesophageal melanomas were noted. Representative tissue was collected from each tumour and immunohistochemical preparations for HMB-45, p53, oestrogen and progesterone receptors were made. A review of oesophageal melanomas reported in the literature was also performed. Results: Three cases of primary malignant melanoma of the oesophagus were found. They accounted for 3% of melanomas and 0.2% of oesophageal cancers diagnosed. The melanomas were fusiform and large at the time of resection. All three patients died of their malignancy within 9 months of operation. The tumours stained positive for HMB-45 and were negative for p53, oestrogen and progesterone receptors. From previous reports, 154 oesophageal melanomas were documented. The tumours were fusiform, large, often pigmented and located in either the middle or lower oesophagus. Although many oesophageal melanomas presented at early stages (stages I or II), their biological behaviour was aggressive. The 5-year survival rate was 5.7%. Conclusions: Melanoma of the oesophagus is an aggressive tumour. There is no evidence for the p53 gene and female sex hormones having a role in the development or progression of the tumour.
Persistent Identifierhttp://hdl.handle.net/10722/84438
ISSN
2015 Impact Factor: 2.94
2015 SCImago Journal Rankings: 1.327
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, KYen_HK
dc.contributor.authorLaw, Sen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T08:52:58Z-
dc.date.available2010-09-06T08:52:58Z-
dc.date.issued1999en_HK
dc.identifier.citationEuropean Journal Of Surgical Oncology, 1999, v. 25 n. 2, p. 168-172en_HK
dc.identifier.issn0748-7983en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84438-
dc.description.abstractAims: Fortunately, primary malignant melanoma of the oesophagus is a rare entity. The aims of this study were to evaluate the clinicopathological features, p53 over-expression and steroid receptors in oesophageal melanomas and to review the reported cases in the literature. Methods: Melanomas reported during a 15-year period (1982-1996) in the Queen Mary Hospital were studied. The clinicopathological features and survival data of patients with oesophageal melanomas were noted. Representative tissue was collected from each tumour and immunohistochemical preparations for HMB-45, p53, oestrogen and progesterone receptors were made. A review of oesophageal melanomas reported in the literature was also performed. Results: Three cases of primary malignant melanoma of the oesophagus were found. They accounted for 3% of melanomas and 0.2% of oesophageal cancers diagnosed. The melanomas were fusiform and large at the time of resection. All three patients died of their malignancy within 9 months of operation. The tumours stained positive for HMB-45 and were negative for p53, oestrogen and progesterone receptors. From previous reports, 154 oesophageal melanomas were documented. The tumours were fusiform, large, often pigmented and located in either the middle or lower oesophagus. Although many oesophageal melanomas presented at early stages (stages I or II), their biological behaviour was aggressive. The 5-year survival rate was 5.7%. Conclusions: Melanoma of the oesophagus is an aggressive tumour. There is no evidence for the p53 gene and female sex hormones having a role in the development or progression of the tumour.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejsoen_HK
dc.relation.ispartofEuropean Journal of Surgical Oncologyen_HK
dc.subjectChineseen_HK
dc.subjectIncidenceen_HK
dc.subjectMelanomaen_HK
dc.subjectOesophagusen_HK
dc.subjectp53en_HK
dc.subjectSteroid receptoren_HK
dc.titleMalignant melanoma of the oesophagus: Clinicopathological features, lack of p53 expression and steroid receptors and a review of the literatureen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0748-7983&volume=25&spage=168&epage=172&date=1999&atitle=Malignant+melanoma+of+the+oesophagus:+clinicopathological+features,+lack+of+p53+expression+and+steroid+receptors+and+a+review+of+the+literatureen_HK
dc.identifier.emailLaw, S: slaw@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityLaw, S=rp00437en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1053/ejso.1998.0621en_HK
dc.identifier.pmid10218460en_HK
dc.identifier.scopuseid_2-s2.0-0032907504en_HK
dc.identifier.hkuros41603en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032907504&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue2en_HK
dc.identifier.spage168en_HK
dc.identifier.epage172en_HK
dc.identifier.isiWOS:000079735100011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridLaw, S=7202241293en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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