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Article: Clinicopathological significance of homeoprotein Six1 in hepatocellular carcinoma

TitleClinicopathological significance of homeoprotein Six1 in hepatocellular carcinoma
Authors
KeywordsHepatectomy
Hepatocellular carcinoma (HCC)
Pathologic tumour-node-metastasis (pTNM) stage
Six1
Survival
Venous infiltration
Issue Date2006
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
Citation
British Journal Of Cancer, 2006, v. 95 n. 8, p. 1050-1055 How to Cite?
AbstractTumour recurrence and metastases of hepatocellular carcinoma (HCC) after hepatectomy are the major obstacles of long-term survival. The present study investigated the clinicopathological significance of a possible metastasis regulator Six1 in HCC patients who were undergone hepatectomy. Seventy-two pairs of RNA and 103 pairs of protein from tumour and adjacent nontumour liver tissues of HCC patients were examined. About 85 and 60% of HCC tumour tissues were found to overexpress Six1 mRNA and protein, respectively, compared with nontumour liver tissues. No Six1 protein was detected in HCC nontumour liver tissues and normal liver tissues. Increased Six1 protein expression in HCC patients was significantly correlated with pathologic tumour-node-metastasis (pTNM) stage (P=0.002), venous infiltration (P=0.004) and poor overall survival (P=0.0423). We concluded that Six1 is frequently overexpressed in HCC patients and elevated Six1 protein in HCC patients may be an indication of advanced stage and poor overall survival after hepatectomy. © 2006 Cancer Research UK.
Persistent Identifierhttp://hdl.handle.net/10722/84335
ISSN
2015 Impact Factor: 5.569
2015 SCImago Journal Rankings: 2.939
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, KTen_HK
dc.contributor.authorMan, Ken_HK
dc.contributor.authorSun, CKen_HK
dc.contributor.authorLee, TKen_HK
dc.contributor.authorPoon, RTen_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T08:51:44Z-
dc.date.available2010-09-06T08:51:44Z-
dc.date.issued2006en_HK
dc.identifier.citationBritish Journal Of Cancer, 2006, v. 95 n. 8, p. 1050-1055en_HK
dc.identifier.issn0007-0920en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84335-
dc.description.abstractTumour recurrence and metastases of hepatocellular carcinoma (HCC) after hepatectomy are the major obstacles of long-term survival. The present study investigated the clinicopathological significance of a possible metastasis regulator Six1 in HCC patients who were undergone hepatectomy. Seventy-two pairs of RNA and 103 pairs of protein from tumour and adjacent nontumour liver tissues of HCC patients were examined. About 85 and 60% of HCC tumour tissues were found to overexpress Six1 mRNA and protein, respectively, compared with nontumour liver tissues. No Six1 protein was detected in HCC nontumour liver tissues and normal liver tissues. Increased Six1 protein expression in HCC patients was significantly correlated with pathologic tumour-node-metastasis (pTNM) stage (P=0.002), venous infiltration (P=0.004) and poor overall survival (P=0.0423). We concluded that Six1 is frequently overexpressed in HCC patients and elevated Six1 protein in HCC patients may be an indication of advanced stage and poor overall survival after hepatectomy. © 2006 Cancer Research UK.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjcen_HK
dc.relation.ispartofBritish Journal of Canceren_HK
dc.subjectHepatectomyen_HK
dc.subjectHepatocellular carcinoma (HCC)en_HK
dc.subjectPathologic tumour-node-metastasis (pTNM) stageen_HK
dc.subjectSix1en_HK
dc.subjectSurvivalen_HK
dc.subjectVenous infiltrationen_HK
dc.subject.meshBlotting, Western-
dc.subject.meshCarcinoma, Hepatocellular - genetics - metabolism - pathology-
dc.subject.meshCell Line, Tumor-
dc.subject.meshHomeodomain Proteins - genetics - metabolism-
dc.subject.meshLiver Neoplasms - genetics - metabolism - pathology-
dc.titleClinicopathological significance of homeoprotein Six1 in hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-0920&volume=95&issue=8&spage=1050&epage=1055&date=2006&atitle=Clinicopathological+significance+of+homeoprotein+Six1+in+hepatocellular+carcinomaen_HK
dc.identifier.emailNg, KT: ledodes@hku.hken_HK
dc.identifier.emailMan, K: kwanman@hku.hken_HK
dc.identifier.emailLee, TK: tkwlee@hkucc.hku.hken_HK
dc.identifier.emailPoon, RT: poontp@hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityNg, KT=rp01720en_HK
dc.identifier.authorityMan, K=rp00417en_HK
dc.identifier.authorityLee, TK=rp00447en_HK
dc.identifier.authorityPoon, RT=rp00446en_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1038/sj.bjc.6603399en_HK
dc.identifier.pmid17008870-
dc.identifier.pmcidPMC2360701-
dc.identifier.scopuseid_2-s2.0-33750207050en_HK
dc.identifier.hkuros124839en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750207050&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume95en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1050en_HK
dc.identifier.epage1055en_HK
dc.identifier.isiWOS:000241384400016-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridNg, KT=7403178513en_HK
dc.identifier.scopusauthoridMan, K=7101754072en_HK
dc.identifier.scopusauthoridSun, CK=7404248685en_HK
dc.identifier.scopusauthoridLee, TK=7501439435en_HK
dc.identifier.scopusauthoridPoon, RT=7103097223en_HK
dc.identifier.scopusauthoridLo, CM=7401771672en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.citeulike876967-

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