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Article: Critical appraisal of the significance of intrathoracic anastomotic leakage after esophagectomy for cancer

TitleCritical appraisal of the significance of intrathoracic anastomotic leakage after esophagectomy for cancer
Authors
KeywordsEsophageal cancer
Intrathoracic anastomotic leak
Mortality
Predisposing factors
Treatment
Issue Date2001
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjsurg
Citation
American Journal Of Surgery, 2001, v. 181 n. 3, p. 198-203 How to Cite?
AbstractBackground: Leakage from esophageal anastomoses is higher than that for other gastrointestinal anastomoses. An intrathoracic anastomotic leak is a potentially catastrophic event. Methods: Patients with and without thoracic anastomotic leakage were compared for predisposing factors. Leak-related mortality was analyzed. Results: Of 475 patients, there were 17 leaks (3.5%). Predisposing technical factors occurred significantly more frequently in patients who leaked. Sixteen such events were identified as contributory in 11 patients. The hospital mortality for patients who leaked was significantly higher (35% versus 9%, P = 0.005). Inadequate drainage and persistent sepsis accounted for 4 of the 6 deaths. The need for inotropic support postoperatively correlated with leak-related mortality (66% versus 0%, P = 0.006), while leak size, time to diagnosis, or method of drainage did not. Conclusions: Thoracic anastomotic leaks are largely preventable. Leak-related mortality for the series was 1% and was most commonly related to inadequate drainage. © 2001 Excerpta Medica, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/84322
ISSN
2015 Impact Factor: 2.403
2015 SCImago Journal Rankings: 1.286
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWhooley, BPen_HK
dc.contributor.authorLaw, Sen_HK
dc.contributor.authorAlexandrou, Aen_HK
dc.contributor.authorMurthy, SCen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T08:51:34Z-
dc.date.available2010-09-06T08:51:34Z-
dc.date.issued2001en_HK
dc.identifier.citationAmerican Journal Of Surgery, 2001, v. 181 n. 3, p. 198-203en_HK
dc.identifier.issn0002-9610en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84322-
dc.description.abstractBackground: Leakage from esophageal anastomoses is higher than that for other gastrointestinal anastomoses. An intrathoracic anastomotic leak is a potentially catastrophic event. Methods: Patients with and without thoracic anastomotic leakage were compared for predisposing factors. Leak-related mortality was analyzed. Results: Of 475 patients, there were 17 leaks (3.5%). Predisposing technical factors occurred significantly more frequently in patients who leaked. Sixteen such events were identified as contributory in 11 patients. The hospital mortality for patients who leaked was significantly higher (35% versus 9%, P = 0.005). Inadequate drainage and persistent sepsis accounted for 4 of the 6 deaths. The need for inotropic support postoperatively correlated with leak-related mortality (66% versus 0%, P = 0.006), while leak size, time to diagnosis, or method of drainage did not. Conclusions: Thoracic anastomotic leaks are largely preventable. Leak-related mortality for the series was 1% and was most commonly related to inadequate drainage. © 2001 Excerpta Medica, Inc.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjsurgen_HK
dc.relation.ispartofAmerican Journal of Surgeryen_HK
dc.rightsThe American Journal of Surgery. Copyright © Elsevier Inc.en_HK
dc.subjectEsophageal canceren_HK
dc.subjectIntrathoracic anastomotic leaken_HK
dc.subjectMortalityen_HK
dc.subjectPredisposing factorsen_HK
dc.subjectTreatmenten_HK
dc.titleCritical appraisal of the significance of intrathoracic anastomotic leakage after esophagectomy for canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9610&volume=181&issue=3&spage=198&epage=203&date=2001&atitle=Critical+appraisal+of+the+significance+of+intrathoracic+anastomotic+leakage+after+esophagectomy+for+canceren_HK
dc.identifier.emailLaw, S: slaw@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityLaw, S=rp00437en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0002-9610(01)00559-1en_HK
dc.identifier.pmid11376570-
dc.identifier.scopuseid_2-s2.0-0035269405en_HK
dc.identifier.hkuros58967en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035269405&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume181en_HK
dc.identifier.issue3en_HK
dc.identifier.spage198en_HK
dc.identifier.epage203en_HK
dc.identifier.isiWOS:000168869400002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWhooley, BP=6602989930en_HK
dc.identifier.scopusauthoridLaw, S=7202241293en_HK
dc.identifier.scopusauthoridAlexandrou, A=12760653800en_HK
dc.identifier.scopusauthoridMurthy, SC=7202013138en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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