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Article: A prospective comparison of locally made rapid urease test and histology for the diagnosis of Helicobacter pylori infection

TitleA prospective comparison of locally made rapid urease test and histology for the diagnosis of Helicobacter pylori infection
Authors
Issue Date1997
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/gie
Citation
Gastrointestinal Endoscopy, 1997, v. 46 n. 6, p. 503-506 How to Cite?
AbstractBackground: A number of noncommercial preparations of urease test have been described. The present prospective study evaluated the accuracy of one such preparation for the diagnosis of Helicobacter pylori infection. Methods: From February 1996 to November 1996, all patients undergoing elective upper endoscopy in a single endoscopy facility were included. Three antral biopsy specimens were taken. Two specimens were subjected to histologic examination, and one specimen was placed into a 'locally made rapid urease test' (LRUT). Results of histologic examinations were taken as standards for comparison. The final result of LRUT was obtained on scrutiny of color changes at 4 hours after the start of the test. Results: Two thousand three hundred sixteen patients (male/female = 1.5:1) with a mean age of 56.7 ± 0.4 years were included. Five hundred sixty-two patients (24.3%) had a history of eradication treatment for H. pylori. Nine hundred fifty-three patients (41.1%) were found to be positive for H. pylori on histologic examination. In patients in whom a history of eradication therapy was absent, the sensitivity, specificity, and positive and negative predictive values of the LRUT were 92.8%, 97.6%, 97.5%, and 93.0%, respectively. In patients with a history of eradication treatment, the corresponding figures were 76.1%, 99.6%, 96.2%, and 96.9%. Conclusions: The locally made rapid urease test provides a simple, safe, rapid, inexpensive, and accurate test for the diagnosis of H. pylori infection.
Persistent Identifierhttp://hdl.handle.net/10722/84264
ISSN
2015 Impact Factor: 6.217
2015 SCImago Journal Rankings: 2.390
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChu, KMen_HK
dc.contributor.authorPoon, Ren_HK
dc.contributor.authorTuen, HHen_HK
dc.contributor.authorLaw, SYKen_HK
dc.contributor.authorBranicki, FJen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T08:50:54Z-
dc.date.available2010-09-06T08:50:54Z-
dc.date.issued1997en_HK
dc.identifier.citationGastrointestinal Endoscopy, 1997, v. 46 n. 6, p. 503-506en_HK
dc.identifier.issn0016-5107en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84264-
dc.description.abstractBackground: A number of noncommercial preparations of urease test have been described. The present prospective study evaluated the accuracy of one such preparation for the diagnosis of Helicobacter pylori infection. Methods: From February 1996 to November 1996, all patients undergoing elective upper endoscopy in a single endoscopy facility were included. Three antral biopsy specimens were taken. Two specimens were subjected to histologic examination, and one specimen was placed into a 'locally made rapid urease test' (LRUT). Results of histologic examinations were taken as standards for comparison. The final result of LRUT was obtained on scrutiny of color changes at 4 hours after the start of the test. Results: Two thousand three hundred sixteen patients (male/female = 1.5:1) with a mean age of 56.7 ± 0.4 years were included. Five hundred sixty-two patients (24.3%) had a history of eradication treatment for H. pylori. Nine hundred fifty-three patients (41.1%) were found to be positive for H. pylori on histologic examination. In patients in whom a history of eradication therapy was absent, the sensitivity, specificity, and positive and negative predictive values of the LRUT were 92.8%, 97.6%, 97.5%, and 93.0%, respectively. In patients with a history of eradication treatment, the corresponding figures were 76.1%, 99.6%, 96.2%, and 96.9%. Conclusions: The locally made rapid urease test provides a simple, safe, rapid, inexpensive, and accurate test for the diagnosis of H. pylori infection.en_HK
dc.languageengen_HK
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/gieen_HK
dc.relation.ispartofGastrointestinal Endoscopyen_HK
dc.rightsGastrointestinal Endoscopy. Copyright © Mosby, Inc.en_HK
dc.titleA prospective comparison of locally made rapid urease test and histology for the diagnosis of Helicobacter pylori infectionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0016-5107&volume=46&spage=503&epage=506&date=1997&atitle=A+prospective+comparison+of+locally+made+rapid+urease+test+and+histology+for+the+diagnosis+of+helicobacter+pylori+infectionen_HK
dc.identifier.emailChu, KM: chukm@hkucc.hku.hken_HK
dc.identifier.emailPoon, R: poontp@hku.hken_HK
dc.identifier.emailLaw, SYK: slaw@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityChu, KM=rp00435en_HK
dc.identifier.authorityPoon, R=rp00446en_HK
dc.identifier.authorityLaw, SYK=rp00437en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9434216-
dc.identifier.scopuseid_2-s2.0-0031445628en_HK
dc.identifier.hkuros29943en_HK
dc.identifier.volume46en_HK
dc.identifier.issue6en_HK
dc.identifier.spage503en_HK
dc.identifier.epage506en_HK
dc.identifier.isiWOS:000071094900004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChu, KM=7402453538en_HK
dc.identifier.scopusauthoridPoon, R=7103097223en_HK
dc.identifier.scopusauthoridTuen, HH=6602991320en_HK
dc.identifier.scopusauthoridLaw, SYK=7202241293en_HK
dc.identifier.scopusauthoridBranicki, FJ=7003617514en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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