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Article: Attenuation of acute phase shear stress by somatostatin improves small-for-size liver graft survival

TitleAttenuation of acute phase shear stress by somatostatin improves small-for-size liver graft survival
Authors
Issue Date2006
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021
Citation
Liver Transplantation, 2006, v. 12 n. 4, p. 621-627 How to Cite?
AbstractThe major concern of living donor liver transplantation is small-for-size graft injury at the early phase after transplantation. Novel therapeutic strategies should be developed. To investigate the protective effect of somatostatin related to hemodynamic stress on small-for-size liver graft injury, we applied a treatment regimen of low-dose somatostatin in a rat orthotopic liver transplantation model using small-for-size grafts (median, 38.7%; range, 35-42%). Somatostatin was given at 5 minutes before total hepatectomy and immediately after reperfusion in the recipient (20 μg/kg). Graft survival, portal hemodynamics, intragraft gene expression and hepatic ultrastructural changes were compared between the rats with or without somatostatin treatment. Seven-day graft survival rates in the somatostatin treatment group were significantly improved compared to the control group (66.7% vs. 16.7%, P = 0.036). In the treatment group, portal pressure and hepatic surface blood flow were significantly decreased within the first 30 minutes after reperfusion, whereas in the control group, transient portal hypertension and excessive hepatic blood flow were observed. Intragraft expression (both messenger RNA and protein) of endothelin-1 was significantly downregulated accompanied with upregulation of heme oxygenase-1 and A20. Better preservation of liver function was found in the treatment group. Hepatic ultrastructure, especially the integrity of sinusoids, was well protected in the treatment group. In conclusion, low-dose somatostatin rescues small-for-size grafts from acute phase injury in liver transplantation by attenuation of acute-phase shear stress that resulted from transient portal hypertension. © 2006 AASLD.
Persistent Identifierhttp://hdl.handle.net/10722/84019
ISSN
2015 Impact Factor: 3.951
2015 SCImago Journal Rankings: 1.763
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXu, Xen_HK
dc.contributor.authorMan, Ken_HK
dc.contributor.authorZheng, SSen_HK
dc.contributor.authorLiang, TBen_HK
dc.contributor.authorLee, TKen_HK
dc.contributor.authorNg, KTen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorLo, CMen_HK
dc.date.accessioned2010-09-06T08:47:58Z-
dc.date.available2010-09-06T08:47:58Z-
dc.date.issued2006en_HK
dc.identifier.citationLiver Transplantation, 2006, v. 12 n. 4, p. 621-627en_HK
dc.identifier.issn1527-6465en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84019-
dc.description.abstractThe major concern of living donor liver transplantation is small-for-size graft injury at the early phase after transplantation. Novel therapeutic strategies should be developed. To investigate the protective effect of somatostatin related to hemodynamic stress on small-for-size liver graft injury, we applied a treatment regimen of low-dose somatostatin in a rat orthotopic liver transplantation model using small-for-size grafts (median, 38.7%; range, 35-42%). Somatostatin was given at 5 minutes before total hepatectomy and immediately after reperfusion in the recipient (20 μg/kg). Graft survival, portal hemodynamics, intragraft gene expression and hepatic ultrastructural changes were compared between the rats with or without somatostatin treatment. Seven-day graft survival rates in the somatostatin treatment group were significantly improved compared to the control group (66.7% vs. 16.7%, P = 0.036). In the treatment group, portal pressure and hepatic surface blood flow were significantly decreased within the first 30 minutes after reperfusion, whereas in the control group, transient portal hypertension and excessive hepatic blood flow were observed. Intragraft expression (both messenger RNA and protein) of endothelin-1 was significantly downregulated accompanied with upregulation of heme oxygenase-1 and A20. Better preservation of liver function was found in the treatment group. Hepatic ultrastructure, especially the integrity of sinusoids, was well protected in the treatment group. In conclusion, low-dose somatostatin rescues small-for-size grafts from acute phase injury in liver transplantation by attenuation of acute-phase shear stress that resulted from transient portal hypertension. © 2006 AASLD.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021en_HK
dc.relation.ispartofLiver Transplantationen_HK
dc.rightsLiver Transplantation. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBiopsyen_HK
dc.subject.meshDNA Primersen_HK
dc.subject.meshDNA Probesen_HK
dc.subject.meshEndothelin-1 - geneticsen_HK
dc.subject.meshGene Expression Profilingen_HK
dc.subject.meshGlucagon - blooden_HK
dc.subject.meshGraft Survival - physiologyen_HK
dc.subject.meshLiver - anatomy & histology - drug effects - ultrastructureen_HK
dc.subject.meshLiver Transplantation - pathology - physiologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshModels, Animalen_HK
dc.subject.meshOrgan Sizeen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Inbred Lewen_HK
dc.subject.meshSomatostatin - therapeutic useen_HK
dc.subject.meshStress, Mechanicalen_HK
dc.subject.meshTransplantation, Isogeneicen_HK
dc.titleAttenuation of acute phase shear stress by somatostatin improves small-for-size liver graft survivalen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1527-6465&volume=12&issue=4&spage=621&epage=627&date=2006&atitle=Attenuation+of+acute+phase+shear+stress+by+somatostatin+improves+small-for-size+liver+graft+survivalen_HK
dc.identifier.emailMan, K: kwanman@hku.hken_HK
dc.identifier.emailLee, TK: tkwlee@hkucc.hku.hken_HK
dc.identifier.emailNg, KT: ledodes@hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.authorityMan, K=rp00417en_HK
dc.identifier.authorityLee, TK=rp00447en_HK
dc.identifier.authorityNg, KT=rp01720en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/lt.20630en_HK
dc.identifier.pmid16555322en_HK
dc.identifier.scopuseid_2-s2.0-33645552213en_HK
dc.identifier.hkuros139257en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645552213&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue4en_HK
dc.identifier.spage621en_HK
dc.identifier.epage627en_HK
dc.identifier.isiWOS:000236534800019-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridXu, X=35772626600en_HK
dc.identifier.scopusauthoridMan, K=7101754072en_HK
dc.identifier.scopusauthoridZheng, SS=7403146419en_HK
dc.identifier.scopusauthoridLiang, TB=7202019213en_HK
dc.identifier.scopusauthoridLee, TK=7501439435en_HK
dc.identifier.scopusauthoridNg, KT=7403178513en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridLo, CM=7401771672en_HK

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