File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Expression of p53 in recurrent nodal metastasis from nasopharyngeal carcinoma (NPC)

TitleExpression of p53 in recurrent nodal metastasis from nasopharyngeal carcinoma (NPC)
Authors
KeywordsNasopharyngeal carcinoma
p53 expression
Recurrent nodal metastasis
Issue Date1997
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejso
Citation
European Journal Of Surgical Oncology, 1997, v. 23 n. 5, p. 415-418 How to Cite?
AbstractThis study reports the incidence of p53 expression in 40 patients with recurrent nodal metastasis from nasopharyngeal carcinoma (NPC) and its prognostic value in this group of patients. Immunohistochemical staining using monoclonal antibody specific for human p53 protein was performed on the tumour-bearing nodes from 40 patients. The results were divided into four grades (I, negative; II, < 10% of cells positive; III, 10-50% of cells positive; and IV, > 50% of cells positive). The staining scores were correlated with histological tumour types, subsequent recurrence and survival. All patients had undergone neck irradiation. Lymph node specimens from six patients (15%) showed positive staining of nuclear p53 protein. The distribution among the different grades was: three (7.5%) for II, two (5%) for III and one (2.5%) for IV. Patients with p53-overexpressed tumours had a significantly higher number of tumour-bearing lymph nodes. There was no correlation of p53 expression with histological tumour types, second tumour recurrence and survival. Expression of p53 appears to be uncommon in patients with recurrent nodal metastases in NPC. It did not have prognostic value in this particular series of patients.
Persistent Identifierhttp://hdl.handle.net/10722/83968
ISSN
2015 Impact Factor: 2.94
2015 SCImago Journal Rankings: 1.327
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChow, LWCen_HK
dc.contributor.authorKhoo, USen_HK
dc.contributor.authorYuen, APWen_HK
dc.contributor.authorWei, WIen_HK
dc.date.accessioned2010-09-06T08:47:21Z-
dc.date.available2010-09-06T08:47:21Z-
dc.date.issued1997en_HK
dc.identifier.citationEuropean Journal Of Surgical Oncology, 1997, v. 23 n. 5, p. 415-418en_HK
dc.identifier.issn0748-7983en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83968-
dc.description.abstractThis study reports the incidence of p53 expression in 40 patients with recurrent nodal metastasis from nasopharyngeal carcinoma (NPC) and its prognostic value in this group of patients. Immunohistochemical staining using monoclonal antibody specific for human p53 protein was performed on the tumour-bearing nodes from 40 patients. The results were divided into four grades (I, negative; II, < 10% of cells positive; III, 10-50% of cells positive; and IV, > 50% of cells positive). The staining scores were correlated with histological tumour types, subsequent recurrence and survival. All patients had undergone neck irradiation. Lymph node specimens from six patients (15%) showed positive staining of nuclear p53 protein. The distribution among the different grades was: three (7.5%) for II, two (5%) for III and one (2.5%) for IV. Patients with p53-overexpressed tumours had a significantly higher number of tumour-bearing lymph nodes. There was no correlation of p53 expression with histological tumour types, second tumour recurrence and survival. Expression of p53 appears to be uncommon in patients with recurrent nodal metastases in NPC. It did not have prognostic value in this particular series of patients.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejsoen_HK
dc.relation.ispartofEuropean Journal of Surgical Oncologyen_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subjectp53 expressionen_HK
dc.subjectRecurrent nodal metastasisen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshCarcinoma - metabolism - secondaryen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Expression Regulation, Neoplasticen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLymphatic Metastasisen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNasopharyngeal Neoplasms - metabolism - pathologyen_HK
dc.subject.meshRecurrenceen_HK
dc.subject.meshSurvival Analysisen_HK
dc.subject.meshTumor Suppressor Protein p53 - biosynthesisen_HK
dc.subject.meshUp-Regulationen_HK
dc.titleExpression of p53 in recurrent nodal metastasis from nasopharyngeal carcinoma (NPC)en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0748-7983&volume=23&spage=415&epage=418&date=1997&atitle=Expression+of+p53+in+recurrent+nodal+metastasis+from+nasopharyngeal+carcinoma+(NPC)en_HK
dc.identifier.emailKhoo, US: uskhoo@hkucc.hku.hken_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0748-7983(97)93721-5en_HK
dc.identifier.pmid9393569-
dc.identifier.scopuseid_2-s2.0-0030777925en_HK
dc.identifier.hkuros29998en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030777925&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue5en_HK
dc.identifier.spage415en_HK
dc.identifier.epage418en_HK
dc.identifier.isiWOS:A1997YG12600007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChow, LWC=7202532995en_HK
dc.identifier.scopusauthoridKhoo, US=7004195799en_HK
dc.identifier.scopusauthoridYuen, APW=7006290111en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats