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Article: Marked suppression of tumor growth by FTY720 in a rat liver tumor model: The significance of down-regulation of cell survival Akt pathway

TitleMarked suppression of tumor growth by FTY720 in a rat liver tumor model: The significance of down-regulation of cell survival Akt pathway
Authors
KeywordsAKT signaling pathway
Apoptosis
Focal adhesion kinase
FTY720
Hepatocellular carcinoma
Issue Date2007
PublisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/ijo/
Citation
International Journal Of Oncology, 2007, v. 30 n. 2, p. 375-380 How to Cite?
AbstractWe aim to investigate the anticancer effect of a novel immunomodulator FTY720 on a rat orthotopic liver tumor model. A buffalo rat orthotopic liver tumor model was established by injection of a buffalo hepatoma cell line MH7777 into the right portal vein. FTY720 was administered by intraperitoneal injection starting at 10 days after tumor cell injection at a dosage of 5 mg/kg/day. FTY720 markedly suppressed tumor growth and inhibited tumor progression by selective induction of apoptosis of tumor cells via down-regulation of phospho-Akt ser473 and up-regulation of cleaved caspase-3, together with decrease of focal adhesion kinase. Moreover, the proliferation index of tumor cells was significantly reduced to 15.92±5.03% by FTY720 compared with that of 42.92±4.47% in the control group (p<0.001). In addition, we confirmed that FTY720 caused no effect on infiltrated lymphocyte in tumor tissue. We conclude that FTY720 is an effective anticancer agent for liver tumor in a rat model without affecting the immune system of the host.
Persistent Identifierhttp://hdl.handle.net/10722/83897
ISSN
2015 Impact Factor: 3.018
2015 SCImago Journal Rankings: 1.270
References

 

DC FieldValueLanguage
dc.contributor.authorNg, KTen_HK
dc.contributor.authorMan, Ken_HK
dc.contributor.authorHo, JWen_HK
dc.contributor.authorSun, CKen_HK
dc.contributor.authorLee, TKen_HK
dc.contributor.authorZhao, Yen_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorPoon, RTen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T08:46:31Z-
dc.date.available2010-09-06T08:46:31Z-
dc.date.issued2007en_HK
dc.identifier.citationInternational Journal Of Oncology, 2007, v. 30 n. 2, p. 375-380en_HK
dc.identifier.issn1019-6439en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83897-
dc.description.abstractWe aim to investigate the anticancer effect of a novel immunomodulator FTY720 on a rat orthotopic liver tumor model. A buffalo rat orthotopic liver tumor model was established by injection of a buffalo hepatoma cell line MH7777 into the right portal vein. FTY720 was administered by intraperitoneal injection starting at 10 days after tumor cell injection at a dosage of 5 mg/kg/day. FTY720 markedly suppressed tumor growth and inhibited tumor progression by selective induction of apoptosis of tumor cells via down-regulation of phospho-Akt ser473 and up-regulation of cleaved caspase-3, together with decrease of focal adhesion kinase. Moreover, the proliferation index of tumor cells was significantly reduced to 15.92±5.03% by FTY720 compared with that of 42.92±4.47% in the control group (p<0.001). In addition, we confirmed that FTY720 caused no effect on infiltrated lymphocyte in tumor tissue. We conclude that FTY720 is an effective anticancer agent for liver tumor in a rat model without affecting the immune system of the host.en_HK
dc.languageengen_HK
dc.publisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/ijo/en_HK
dc.relation.ispartofInternational Journal of Oncologyen_HK
dc.subjectAKT signaling pathwayen_HK
dc.subjectApoptosisen_HK
dc.subjectFocal adhesion kinaseen_HK
dc.subjectFTY720en_HK
dc.subjectHepatocellular carcinomaen_HK
dc.titleMarked suppression of tumor growth by FTY720 in a rat liver tumor model: The significance of down-regulation of cell survival Akt pathwayen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1019-6439&volume=30&issue=2&spage=375&epage=380&date=2007&atitle=Marked+suppression+of+tumor+growth+by+FTY720+in+a+rat+liver+tumor+model:+the+significance+of+down-regulation+of+cell+survival+Akt+pathwayen_HK
dc.identifier.emailNg, KT: ledodes@hku.hken_HK
dc.identifier.emailMan, K: kwanman@hku.hken_HK
dc.identifier.emailLee, TK: tkwlee@hkucc.hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.emailPoon, RT: poontp@hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityNg, KT=rp01720en_HK
dc.identifier.authorityMan, K=rp00417en_HK
dc.identifier.authorityLee, TK=rp00447en_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.authorityPoon, RT=rp00446en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.scopuseid_2-s2.0-34047255599en_HK
dc.identifier.hkuros125538en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34047255599&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue2en_HK
dc.identifier.spage375en_HK
dc.identifier.epage380en_HK
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridNg, KT=7403178513en_HK
dc.identifier.scopusauthoridMan, K=7101754072en_HK
dc.identifier.scopusauthoridHo, JW=7402649982en_HK
dc.identifier.scopusauthoridSun, CK=7404248685en_HK
dc.identifier.scopusauthoridLee, TK=7501439435en_HK
dc.identifier.scopusauthoridZhao, Y=7406632804en_HK
dc.identifier.scopusauthoridLo, CM=7401771672en_HK
dc.identifier.scopusauthoridPoon, RT=7103097223en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK

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