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Article: Prospective randomised study on radiotherapy and surgery in the treatment of oesophageal carcinoma

TitleProspective randomised study on radiotherapy and surgery in the treatment of oesophageal carcinoma
Authors
Issue Date1994
PublisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#description
Citation
Asian Journal Of Surgery, 1994, v. 17 n. 3, p. 223-229 How to Cite?
AbstractBetween 1968 and 1981, a randomised prospective study was carried out on 156 patients with resectable and potentially curable middle third squamous cell carcinoma of the oesophagus. Four different management protocols were compared; surgery alone, pre-operative radiotherapy, postoperative radiotherapy and radiotherapy alone. Patients were given appropriate additional treatment for recurrent or metastatic disease. Operative mortality was significantly higher in the pre-operative radiotherapy group (30%) than in the other surgical groups (p < 0.001). The deaths were mainly due to postoperative chest infections. Of the patients initially treated with radiotherapy alone, more than one third required subsequent surgery within a year because of persistent dysphagia. In patients who failed radiotherapy treatment, the operative mortality was 54%. The radiotherapy alone group also had a significantly increased incidence of local recurrence compared with the other groups (76% vs 30% respectively, p < 0.001). Pre-operative radiotherapy had a lower incidence of metastases compared with the surgical groups, and postoperative radiotherapy had a lower incidence of local recurrence compared to surgery alone; neither, however, were statistically significant. There was no differences in the long term survival of the four groups but there were significant differences in the short and medium-term survivals. Patients treated with radiotherapy alone had the worst one- and two-year survival compared with the surgical groups (p < 0.05). Patients treated with pre-operative radiotherapy also had significantly lower six-month survival compared with the other surgical groups, chiefly because of the high operative mortality (p < 0.0025). Survival at 18 months for patients treated by postoperative radiotherapy was also worse than the surgery alone group (p < 0.05). It was concluded that surgery alone was the best primary treatment for resectable oesophageal cancer.
Persistent Identifierhttp://hdl.handle.net/10722/83864
ISSN
2015 Impact Factor: 0.912
2015 SCImago Journal Rankings: 0.427

 

DC FieldValueLanguage
dc.contributor.authorFok, Men_HK
dc.contributor.authorMcShane, Jen_HK
dc.contributor.authorLaw, SYKen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T08:46:08Z-
dc.date.available2010-09-06T08:46:08Z-
dc.date.issued1994en_HK
dc.identifier.citationAsian Journal Of Surgery, 1994, v. 17 n. 3, p. 223-229en_HK
dc.identifier.issn1015-9584en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83864-
dc.description.abstractBetween 1968 and 1981, a randomised prospective study was carried out on 156 patients with resectable and potentially curable middle third squamous cell carcinoma of the oesophagus. Four different management protocols were compared; surgery alone, pre-operative radiotherapy, postoperative radiotherapy and radiotherapy alone. Patients were given appropriate additional treatment for recurrent or metastatic disease. Operative mortality was significantly higher in the pre-operative radiotherapy group (30%) than in the other surgical groups (p < 0.001). The deaths were mainly due to postoperative chest infections. Of the patients initially treated with radiotherapy alone, more than one third required subsequent surgery within a year because of persistent dysphagia. In patients who failed radiotherapy treatment, the operative mortality was 54%. The radiotherapy alone group also had a significantly increased incidence of local recurrence compared with the other groups (76% vs 30% respectively, p < 0.001). Pre-operative radiotherapy had a lower incidence of metastases compared with the surgical groups, and postoperative radiotherapy had a lower incidence of local recurrence compared to surgery alone; neither, however, were statistically significant. There was no differences in the long term survival of the four groups but there were significant differences in the short and medium-term survivals. Patients treated with radiotherapy alone had the worst one- and two-year survival compared with the surgical groups (p < 0.05). Patients treated with pre-operative radiotherapy also had significantly lower six-month survival compared with the other surgical groups, chiefly because of the high operative mortality (p < 0.0025). Survival at 18 months for patients treated by postoperative radiotherapy was also worse than the surgery alone group (p < 0.05). It was concluded that surgery alone was the best primary treatment for resectable oesophageal cancer.en_HK
dc.languageengen_HK
dc.publisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#descriptionen_HK
dc.relation.ispartofAsian Journal of Surgeryen_HK
dc.titleProspective randomised study on radiotherapy and surgery in the treatment of oesophageal carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1015-9584&volume=17&spage=223&epage=229&date=1994&atitle=Prospective+randomised+study+on+radiotherapy+and+surgery+in+the+treatment+of+oesophageal+carcinomaen_HK
dc.identifier.emailLaw, SYK: slaw@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityLaw, SYK=rp00437en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-0028135192en_HK
dc.identifier.hkuros7162en_HK
dc.identifier.volume17en_HK
dc.identifier.issue3en_HK
dc.identifier.spage223en_HK
dc.identifier.epage229en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridFok, M=7005879262en_HK
dc.identifier.scopusauthoridMcShane, J=23393225000en_HK
dc.identifier.scopusauthoridLaw, SYK=7202241293en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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