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Article: Esophageal small cell carcinomas: Clinicopathologic parameters, p53 overexpression, proliferation marker, and their impact on pathogenesis

TitleEsophageal small cell carcinomas: Clinicopathologic parameters, p53 overexpression, proliferation marker, and their impact on pathogenesis
Authors
Issue Date2000
PublisherCollege of American Pathologists. The Journal's web site is located at http://arpa.allenpress.com/arpaonline/?request=index-html
Citation
Archives Of Pathology And Laboratory Medicine, 2000, v. 124 n. 2, p. 228-233 How to Cite?
AbstractObjective.-To evaluate the clinicopathologic features and the roles of p53 and MIB-1 in esophageal small cell carcinoma. Method.-Twenty patients (14 men and 6 women) with esophageal small cell carcinoma treated in our hospital from 1982 through 1996 were studied. The clinicopathologic features, treatment received, and survival data of these patients were documented. Representative tissue was collected from each tumor, and immunohistochemical preparations for p53 protein and MIB-1 were made. Results.-Small cell carcinoma accounted for 1.3% of all esophageal malignant tumors. The median age of patients at presentation was 60 years. On gross examination, the tumors were large ulcerative lesions (median length, 7.5 cm). In 17 patients in whom p53 immunohistochemical study was performed, p53 protein was detected in 65% (9 of 17). All stage IV tumors were negative for p53 expression. The median tumor cell MIB-1 score was high at 855 (range, 810-964) positive cells per 1000. Overall median survival was 3.4 months. In patients who underwent chemotherapy, there was significant response. Conclusions.-Esophageal small cell carcinoma is an aggressive tumor. Overexpression of p53 is associated with early stages of carcinogenesis. The high proliferative index, as defined by the MIB-1 immunohistochemical method, may be related to aggressive behavior and high sensitivity to chemotherapy and radiotherapy.
Persistent Identifierhttp://hdl.handle.net/10722/83802
ISSN
2015 Impact Factor: 2.631
2015 SCImago Journal Rankings: 1.158
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, KYen_HK
dc.contributor.authorLaw, Sen_HK
dc.contributor.authorTung, PHMen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T08:45:23Z-
dc.date.available2010-09-06T08:45:23Z-
dc.date.issued2000en_HK
dc.identifier.citationArchives Of Pathology And Laboratory Medicine, 2000, v. 124 n. 2, p. 228-233en_HK
dc.identifier.issn0003-9985en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83802-
dc.description.abstractObjective.-To evaluate the clinicopathologic features and the roles of p53 and MIB-1 in esophageal small cell carcinoma. Method.-Twenty patients (14 men and 6 women) with esophageal small cell carcinoma treated in our hospital from 1982 through 1996 were studied. The clinicopathologic features, treatment received, and survival data of these patients were documented. Representative tissue was collected from each tumor, and immunohistochemical preparations for p53 protein and MIB-1 were made. Results.-Small cell carcinoma accounted for 1.3% of all esophageal malignant tumors. The median age of patients at presentation was 60 years. On gross examination, the tumors were large ulcerative lesions (median length, 7.5 cm). In 17 patients in whom p53 immunohistochemical study was performed, p53 protein was detected in 65% (9 of 17). All stage IV tumors were negative for p53 expression. The median tumor cell MIB-1 score was high at 855 (range, 810-964) positive cells per 1000. Overall median survival was 3.4 months. In patients who underwent chemotherapy, there was significant response. Conclusions.-Esophageal small cell carcinoma is an aggressive tumor. Overexpression of p53 is associated with early stages of carcinogenesis. The high proliferative index, as defined by the MIB-1 immunohistochemical method, may be related to aggressive behavior and high sensitivity to chemotherapy and radiotherapy.en_HK
dc.languageengen_HK
dc.publisherCollege of American Pathologists. The Journal's web site is located at http://arpa.allenpress.com/arpaonline/?request=index-htmlen_HK
dc.relation.ispartofArchives of Pathology and Laboratory Medicineen_HK
dc.titleEsophageal small cell carcinomas: Clinicopathologic parameters, p53 overexpression, proliferation marker, and their impact on pathogenesisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0363-0153&volume=124&spage=228&epage=233&date=2000&atitle=Esophageal+small+cell+carcinomas+-+clinicopathologic+parameters,+p53+overexpression,+proliferation+marker,+and+their+impact+on+pathogenesisen_HK
dc.identifier.emailLaw, S: slaw@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityLaw, S=rp00437en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10656731-
dc.identifier.scopuseid_2-s2.0-0033950599en_HK
dc.identifier.hkuros53208en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033950599&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume124en_HK
dc.identifier.issue2en_HK
dc.identifier.spage228en_HK
dc.identifier.epage233en_HK
dc.identifier.isiWOS:000085297100010-
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridLaw, S=7202241293en_HK
dc.identifier.scopusauthoridTung, PHM=7006585735en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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