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Article: Reduced expression of RASSF1A in esophageal and nasopharyngeal carcinomas significantly correlates with tumor stage

TitleReduced expression of RASSF1A in esophageal and nasopharyngeal carcinomas significantly correlates with tumor stage
Authors
Lo, PHYXie, DChan, KCXu, FPKuzmin, ILerman, MILaw, SChua, DSham, JLung, ML
KeywordsEsophageal cancer
Nasopharyngeal carcinoma
RASSF1A
Tissue microarray
Issue Date2007
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2007, v. 257 n. 2, p. 199-205 How to Cite?
DOI: http://dx.doi.org/10.1016/j.canlet.2007.07.018
AbstractReduced expression or loss of tumor suppressor genes play a key role in many cancers. In this study, we investigated the role of RASSF1A in the pathogenesis of esophageal squamous cell carcinoma (ESCC) and nasopharyngeal carcinoma (NPC). We detected the down-regulated expression of both RASSF1A transcripts and protein in tumor tissues using RT-PCR and tissue microarray immunohistochemical staining analyses. Down-regulated expression of RASSF1A showed a significant association with WHO grade, tumor status, and lymph node metastasis, showing its possible utility as a biomarker for clinical specimens. © 2007 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/83744
ISSN
0304-3835
2023 Impact Factor: 9.1
2023 SCImago Journal Rankings: 2.595
ISI Accession Number ID
WOS:000250912100007
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLo, PHYen_HK
dc.contributor.authorXie, Den_HK
dc.contributor.authorChan, KCen_HK
dc.contributor.authorXu, FPen_HK
dc.contributor.authorKuzmin, Ien_HK
dc.contributor.authorLerman, MIen_HK
dc.contributor.authorLaw, Sen_HK
dc.contributor.authorChua, Den_HK
dc.contributor.authorSham, Jen_HK
dc.contributor.authorLung, MLen_HK
dc.date.accessioned2010-09-06T08:44:42Z-
dc.date.available2010-09-06T08:44:42Z-
dc.date.issued2007en_HK
dc.identifier.citationCancer Letters, 2007, v. 257 n. 2, p. 199-205en_HK
dc.identifier.issn0304-3835en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83744-
dc.description.abstractReduced expression or loss of tumor suppressor genes play a key role in many cancers. In this study, we investigated the role of RASSF1A in the pathogenesis of esophageal squamous cell carcinoma (ESCC) and nasopharyngeal carcinoma (NPC). We detected the down-regulated expression of both RASSF1A transcripts and protein in tumor tissues using RT-PCR and tissue microarray immunohistochemical staining analyses. Down-regulated expression of RASSF1A showed a significant association with WHO grade, tumor status, and lymph node metastasis, showing its possible utility as a biomarker for clinical specimens. © 2007 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_HK
dc.relation.ispartofCancer Lettersen_HK
dc.rightsCancer Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectEsophageal canceren_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subjectRASSF1Aen_HK
dc.subjectTissue microarrayen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshBlotting, Westernen_HK
dc.subject.meshCarcinoma, Squamous Cell - genetics - metabolism - pathologyen_HK
dc.subject.meshEsophageal Neoplasms - genetics - metabolism - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Expression Regulation, Neoplasticen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNasopharyngeal Neoplasms - genetics - metabolism - pathologyen_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshTissue Array Analysisen_HK
dc.subject.meshTumor Suppressor Proteins - genetics - metabolismen_HK
dc.titleReduced expression of RASSF1A in esophageal and nasopharyngeal carcinomas significantly correlates with tumor stageen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3835&volume=257&issue=2&spage=199&epage=205&date=2007&atitle=Reduced+expression+of+RASSF1A+in+esophageal+and+nasopharyngeal+carcinomas+significantly+correlates+with+tumor+stageen_HK
dc.identifier.emailLaw, S: slaw@hku.hken_HK
dc.identifier.emailChua, D: dttchua@hkucc.hku.hken_HK
dc.identifier.emailLung, ML: mlilung@hku.hken_HK
dc.identifier.authorityLaw, S=rp00437en_HK
dc.identifier.authorityChua, D=rp00415en_HK
dc.identifier.authorityLung, ML=rp00300en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.canlet.2007.07.018en_HK
dc.identifier.pmid17720308-
dc.identifier.scopuseid_2-s2.0-35148856846en_HK
dc.identifier.hkuros138786en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35148856846&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume257en_HK
dc.identifier.issue2en_HK
dc.identifier.spage199en_HK
dc.identifier.epage205en_HK
dc.identifier.isiWOS:000250912100007-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridLo, PHY=36762664000en_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.scopusauthoridChan, KC=22633516900en_HK
dc.identifier.scopusauthoridXu, FP=12647094900en_HK
dc.identifier.scopusauthoridKuzmin, I=7003925098en_HK
dc.identifier.scopusauthoridLerman, MI=24356375900en_HK
dc.identifier.scopusauthoridLaw, S=7202241293en_HK
dc.identifier.scopusauthoridChua, D=7006773480en_HK
dc.identifier.scopusauthoridSham, J=24472255400en_HK
dc.identifier.scopusauthoridLung, ML=7006411788en_HK
dc.identifier.issnl0304-3835-

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