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Article: Telomerase activity in small cell esophageal carcinoma

TitleTelomerase activity in small cell esophageal carcinoma
Authors
Issue Date2001
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DES
Citation
Diseases Of The Esophagus, 2001, v. 14 n. 2, p. 139-142 How to Cite?
AbstractSmall cell carcinoma of the esophagus is a rare and aggressive malignant tumor. Telomerase activation is common in human cancers. There is a lack of data on telomerase activity in esophageal small cell cancers. The present report studied the role of telomerase activity in esophageal small cell carcinoma. The clinicopathologic data of five patients with small cell carcinoma of the esophagus who underwent primary surgical treatment between 1991 and 2000 were studied. Telomeric repeat amplification protocol assays were used to investigate telomerase activity in these tumors. The proliferative activity (MIB-1) and p53 expression of these tumors were also studied using immunohistochemistry and correlated with the telomerase activity. All five small cell carcinomas showed detectable telomerase activity in the primary tumor. Two out of the five morphologically normal esophageal mucosae adjacent to the primary tumor had detectable telomerase activity. There was no correlation between the p53 expression, tumor stage, survival of patients, and the presence of telomerase activity. High MIB-1 expression in esophageal small cell carcinomas was associated with high telomerase activity. Telomerase activation is common in small cell carcinoma of the esophagus. This fact may find application in anti-telomerase treatment for this aggressive tumor.
Persistent Identifierhttp://hdl.handle.net/10722/83503
ISSN
2015 Impact Factor: 2.146
2015 SCImago Journal Rankings: 0.760
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChow, Ven_HK
dc.contributor.authorLaw, Sen_HK
dc.contributor.authorLam, KYen_HK
dc.contributor.authorLuk, JMen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T08:41:49Z-
dc.date.available2010-09-06T08:41:49Z-
dc.date.issued2001en_HK
dc.identifier.citationDiseases Of The Esophagus, 2001, v. 14 n. 2, p. 139-142en_HK
dc.identifier.issn1120-8694en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83503-
dc.description.abstractSmall cell carcinoma of the esophagus is a rare and aggressive malignant tumor. Telomerase activation is common in human cancers. There is a lack of data on telomerase activity in esophageal small cell cancers. The present report studied the role of telomerase activity in esophageal small cell carcinoma. The clinicopathologic data of five patients with small cell carcinoma of the esophagus who underwent primary surgical treatment between 1991 and 2000 were studied. Telomeric repeat amplification protocol assays were used to investigate telomerase activity in these tumors. The proliferative activity (MIB-1) and p53 expression of these tumors were also studied using immunohistochemistry and correlated with the telomerase activity. All five small cell carcinomas showed detectable telomerase activity in the primary tumor. Two out of the five morphologically normal esophageal mucosae adjacent to the primary tumor had detectable telomerase activity. There was no correlation between the p53 expression, tumor stage, survival of patients, and the presence of telomerase activity. High MIB-1 expression in esophageal small cell carcinomas was associated with high telomerase activity. Telomerase activation is common in small cell carcinoma of the esophagus. This fact may find application in anti-telomerase treatment for this aggressive tumor.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DESen_HK
dc.relation.ispartofDiseases of the Esophagusen_HK
dc.titleTelomerase activity in small cell esophageal carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1120-8694&volume=14&issue=2&spage=139&epage=142&date=2001&atitle=Telomerase+activity+in+small+cell+esophageal+carcinomaen_HK
dc.identifier.emailLaw, S: slaw@hku.hken_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityLaw, S=rp00437en_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1442-2050.2001.00172.xen_HK
dc.identifier.pmid11553225-
dc.identifier.scopuseid_2-s2.0-0034789420en_HK
dc.identifier.hkuros107453en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034789420&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue2en_HK
dc.identifier.spage139en_HK
dc.identifier.epage142en_HK
dc.identifier.isiWOS:000171478400013-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridChow, V=7006616213en_HK
dc.identifier.scopusauthoridLaw, S=7202241293en_HK
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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