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Article: One-week once-daily triple therapy for Helicobacter pylori - A pilot study

TitleOne-week once-daily triple therapy for Helicobacter pylori - A pilot study
Authors
KeywordsEradication
Helicobacter pylori
Issue Date2000
PublisherHepato-Gastroenterology. The Journal's web site is located at http://www.thieme.de/hepato/index.html
Citation
Hepato-Gastroenterology, 2000, v. 47 n. 36, p. 1624-1626 How to Cite?
AbstractBackground/Aims: Proton-pump inhibitor-based triple therapy given over one to two weeks is currently one of the recommended regimens for eradication of Helicobacter pylori. Most of these regimens require twice daily intake of medication. The present study explored the possibility of using a one-week once-daify triple therapy in the eradication of H. pylori. Methodology: Thirty-two consecutive patients with acid-peptic disease associated with H. pylori infection (duodenal ulcer 18 patients; gastric ulcer 8 patients; duodenitis 1 patient; gastritis 5 patients) were prospectively recruited. They were given a 1-week course of lansoprazole 30mg, clarithromycin modified-release 500mg, and metronidazole 800mg, all taken once daily. Resets: The age of these 32 patients ranged from 17-89 years with a mean of 57.5 years. Side effects occurred in 5 patients (15.6%; 95%Cl: 5.3-32.8%). All patients finished the treatment and underwent a second endoscopy. Positive endoscopic finding was found in one patient (3.1%; 95%Cl: 0.07-16.2%). On intent-to-treat and per protocol analysis, the eradication rate was 87.5% (95%Cl: 71.0-96.5%). Conclusions: A one-week once-daily course of lansoprazole, clarithromycin modified release and metronidazole is a safe, well-tolerated, easy to comply with, and efficacious treatment for H. pylori infection. In view of the small sample size, further studies should be performed to validate its effectiveness.
Persistent Identifierhttp://hdl.handle.net/10722/83293
ISSN
2015 Impact Factor: 0.792
2015 SCImago Journal Rankings: 0.446
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChu, KMen_HK
dc.contributor.authorKwok, KFen_HK
dc.contributor.authorLaw, SYKen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T08:39:18Z-
dc.date.available2010-09-06T08:39:18Z-
dc.date.issued2000en_HK
dc.identifier.citationHepato-Gastroenterology, 2000, v. 47 n. 36, p. 1624-1626en_HK
dc.identifier.issn0172-6390en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83293-
dc.description.abstractBackground/Aims: Proton-pump inhibitor-based triple therapy given over one to two weeks is currently one of the recommended regimens for eradication of Helicobacter pylori. Most of these regimens require twice daily intake of medication. The present study explored the possibility of using a one-week once-daify triple therapy in the eradication of H. pylori. Methodology: Thirty-two consecutive patients with acid-peptic disease associated with H. pylori infection (duodenal ulcer 18 patients; gastric ulcer 8 patients; duodenitis 1 patient; gastritis 5 patients) were prospectively recruited. They were given a 1-week course of lansoprazole 30mg, clarithromycin modified-release 500mg, and metronidazole 800mg, all taken once daily. Resets: The age of these 32 patients ranged from 17-89 years with a mean of 57.5 years. Side effects occurred in 5 patients (15.6%; 95%Cl: 5.3-32.8%). All patients finished the treatment and underwent a second endoscopy. Positive endoscopic finding was found in one patient (3.1%; 95%Cl: 0.07-16.2%). On intent-to-treat and per protocol analysis, the eradication rate was 87.5% (95%Cl: 71.0-96.5%). Conclusions: A one-week once-daily course of lansoprazole, clarithromycin modified release and metronidazole is a safe, well-tolerated, easy to comply with, and efficacious treatment for H. pylori infection. In view of the small sample size, further studies should be performed to validate its effectiveness.en_HK
dc.languageengen_HK
dc.publisherHepato-Gastroenterology. The Journal's web site is located at http://www.thieme.de/hepato/index.htmlen_HK
dc.relation.ispartofHepato-Gastroenterologyen_HK
dc.subjectEradicationen_HK
dc.subjectHelicobacter pylorien_HK
dc.titleOne-week once-daily triple therapy for Helicobacter pylori - A pilot studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0172-6390&volume=47&issue=36&spage=1624&epage=1626&date=2000&atitle=One-week+once-daily+triple+therapy+for+Helicobacter+pylori+-+a+pilot+studyen_HK
dc.identifier.emailChu, KM: chukm@hkucc.hku.hken_HK
dc.identifier.emailLaw, SYK: slaw@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityChu, KM=rp00435en_HK
dc.identifier.authorityLaw, SYK=rp00437en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11149018-
dc.identifier.scopuseid_2-s2.0-0033635995en_HK
dc.identifier.hkuros58942en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033635995&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume47en_HK
dc.identifier.issue36en_HK
dc.identifier.spage1624en_HK
dc.identifier.epage1626en_HK
dc.identifier.isiWOS:000165865600034-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridChu, KM=7402453538en_HK
dc.identifier.scopusauthoridKwok, KF=7102194177en_HK
dc.identifier.scopusauthoridLaw, SYK=7202241293en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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