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Article: Multiple primary cancers in esophageal squamous cell carcinoma: Incidence and implications

TitleMultiple primary cancers in esophageal squamous cell carcinoma: Incidence and implications
Authors
Issue Date1998
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/athoracsur
Citation
Annals Of Thoracic Surgery, 1998, v. 65 n. 6, p. 1529-1534 How to Cite?
AbstractBackground. The occurrence of multiple primary cancers in the aerodigestive tract is a well-known phenomenon. This study aims to elucidate the incidence and the therapeutic and prognostic implications of a nonesophageal primary cancer in patients with squamous cell carcinoma of the esophagus. Methods. Between 1982 and 1996, 1,055 patients with esophageal squamous cell carcinoma treated at our institution were reviewed for the presence of an additional primary cancer. The effects of the nonesophageal cancer on treatment of the esophageal carcinoma and survival were analyzed. Results. Among 1,055 patients, 114 nonesophageal primary cancers were documented in 100 patients (9.5%), 70% of which were aerodigestive tract cancers. Fortyseven patients had antecedent tumors and 43 had synchronous tumors. Treatment strategies for esophageal carcinoma in these patients were similar to patients without multiple tumors, not influenced by the nonesophageal tumor except in 6 patients. The overall survival of patients with antecedent tumors, synchronous tumors, and without multiple tumors was similar (median survival, 8.6, 8.5, and 8.8 months, respectively) (p = 0.84). Subsequent primary cancers developed in 10 patients (0.9%), 9 of them with previous curative resection of esophageal cancer, and all died of the subsequent cancer. Conclusions. There is a high incidence of multiple primary cancers in patients with esophageal carcinoma but the treatment and prognosis of these patients are primarily determined by the esophageal carcinoma itself. Subsequent cancer is, however, a significant cause of death among patients cured of esophageal carcinoma.
Persistent Identifierhttp://hdl.handle.net/10722/83183
ISSN
2015 Impact Factor: 2.975
2015 SCImago Journal Rankings: 1.490
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorLaw, SYKen_HK
dc.contributor.authorChu, KMen_HK
dc.contributor.authorBranicki, FJen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T08:38:00Z-
dc.date.available2010-09-06T08:38:00Z-
dc.date.issued1998en_HK
dc.identifier.citationAnnals Of Thoracic Surgery, 1998, v. 65 n. 6, p. 1529-1534en_HK
dc.identifier.issn0003-4975en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83183-
dc.description.abstractBackground. The occurrence of multiple primary cancers in the aerodigestive tract is a well-known phenomenon. This study aims to elucidate the incidence and the therapeutic and prognostic implications of a nonesophageal primary cancer in patients with squamous cell carcinoma of the esophagus. Methods. Between 1982 and 1996, 1,055 patients with esophageal squamous cell carcinoma treated at our institution were reviewed for the presence of an additional primary cancer. The effects of the nonesophageal cancer on treatment of the esophageal carcinoma and survival were analyzed. Results. Among 1,055 patients, 114 nonesophageal primary cancers were documented in 100 patients (9.5%), 70% of which were aerodigestive tract cancers. Fortyseven patients had antecedent tumors and 43 had synchronous tumors. Treatment strategies for esophageal carcinoma in these patients were similar to patients without multiple tumors, not influenced by the nonesophageal tumor except in 6 patients. The overall survival of patients with antecedent tumors, synchronous tumors, and without multiple tumors was similar (median survival, 8.6, 8.5, and 8.8 months, respectively) (p = 0.84). Subsequent primary cancers developed in 10 patients (0.9%), 9 of them with previous curative resection of esophageal cancer, and all died of the subsequent cancer. Conclusions. There is a high incidence of multiple primary cancers in patients with esophageal carcinoma but the treatment and prognosis of these patients are primarily determined by the esophageal carcinoma itself. Subsequent cancer is, however, a significant cause of death among patients cured of esophageal carcinoma.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/athoracsuren_HK
dc.relation.ispartofAnnals of Thoracic Surgeryen_HK
dc.rightsThe Annals of Thoracic Surgery. Copyright © Elsevier Inc.en_HK
dc.titleMultiple primary cancers in esophageal squamous cell carcinoma: Incidence and implicationsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-4975&volume=65&spage=1529&epage=1534&date=1998&atitle=Multiple+primary+cancers+in+esophageal+squamous+cell+carcinoma:+incidence+and+implicationsen_HK
dc.identifier.emailPoon, RTP: poontp@hku.hken_HK
dc.identifier.emailLaw, SYK: slaw@hku.hken_HK
dc.identifier.emailChu, KM: chukm@hkucc.hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityLaw, SYK=rp00437en_HK
dc.identifier.authorityChu, KM=rp00435en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0003-4975(98)00177-5en_HK
dc.identifier.pmid9647053-
dc.identifier.scopuseid_2-s2.0-0031810979en_HK
dc.identifier.hkuros32756en_HK
dc.identifier.hkuros40315-
dc.identifier.volume65en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1529en_HK
dc.identifier.epage1534en_HK
dc.identifier.isiWOS:000074274100005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridLaw, SYK=7202241293en_HK
dc.identifier.scopusauthoridChu, KM=7402453538en_HK
dc.identifier.scopusauthoridBranicki, FJ=7003617514en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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