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Article: Gastrointestinal autonomic nerve tumor of the esophagus: A clinicopathologic, immunohistochemical, ultrastructural study of a case and review of the literature

TitleGastrointestinal autonomic nerve tumor of the esophagus: A clinicopathologic, immunohistochemical, ultrastructural study of a case and review of the literature
Authors
Keywordsautonomic nerve tumor
esophagus
immunohistochemistry
stromal tumor
ultrastructural
Issue Date1996
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 1996, v. 78 n. 8, p. 1651-1659 How to Cite?
AbstractBACKGROUND. Gastrointestinal autonomic nerve (GAN) tumor is a rare tumor that is supposed to originate from the enteric autonomic plexus. The tumor is a sub-group of the gastrointestinal stromal tumor that usually occurs in the stomach and small intestine. METHODS. An intramural tumor located in the upper third of the esophagus of a 62-year-old Chinese female is reported. The tumor was removed by a three-phased esophagogastrectomy because of its large size. The tumor measured 6.5 cm x 5 cm x 4 cm. Its tissues were sampled, examined by light microscopy, immunohistochemistry, and electron microscopy. RESULTS. The tumor was vaguely encapsulated but had foci of partial infiltration of the capsule. It was comprised of spindle cells with moderate nuclear pleomorphism. The mitotic count was less than 1 per 10 high-power field. The tumor stained positive for vimentin, neuron specific enolase (NSE), and S 100 protein, and was negative for cytokeratins, synaptophysin, chromogranin, neurofilaments, muscle markers, HMB45, and CD34. Ultrastructural study revealed that the tumor had cytoplasmic processes interdigitated in a complex fashion that were held together by primitive junctions but not invested in basal lamina. Many neurosecretory granules and neurotubules were also noted. The diagnosis was GAN tumor of the esophagus. From previous reports, 43 cases (25 males, 18 females) of GAN tumor of other locations have been documented. The tumors were located almost exclusively in the stomach and small intestine: rare cases arose primarily in the retroperitoneum and mesentery. Some of these GAN tumors were observed in patients with Carney's triad (three cases), neurofibromatosis (two cases), and adrenal ganglioneuroma (one case). It appears that the biologic behavior of GAN tumors is aggressive but there are too few reports on which to conclude anything about their prognosis. The tumors are usually large, with low mitotic rate, and are positive for NSE and negative for muscle markers. CONCLUSIONS. To the authors' knowledge, this is the first time that GAN is described in the esophagus. The diagnosis can be made only on the basis of characteristic ultrastructural features.
Persistent Identifierhttp://hdl.handle.net/10722/83102
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, KYen_HK
dc.contributor.authorLaw, SYKen_HK
dc.contributor.authorChu, KMen_HK
dc.contributor.authorMa, LTen_HK
dc.date.accessioned2010-09-06T08:37:02Z-
dc.date.available2010-09-06T08:37:02Z-
dc.date.issued1996en_HK
dc.identifier.citationCancer, 1996, v. 78 n. 8, p. 1651-1659en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/83102-
dc.description.abstractBACKGROUND. Gastrointestinal autonomic nerve (GAN) tumor is a rare tumor that is supposed to originate from the enteric autonomic plexus. The tumor is a sub-group of the gastrointestinal stromal tumor that usually occurs in the stomach and small intestine. METHODS. An intramural tumor located in the upper third of the esophagus of a 62-year-old Chinese female is reported. The tumor was removed by a three-phased esophagogastrectomy because of its large size. The tumor measured 6.5 cm x 5 cm x 4 cm. Its tissues were sampled, examined by light microscopy, immunohistochemistry, and electron microscopy. RESULTS. The tumor was vaguely encapsulated but had foci of partial infiltration of the capsule. It was comprised of spindle cells with moderate nuclear pleomorphism. The mitotic count was less than 1 per 10 high-power field. The tumor stained positive for vimentin, neuron specific enolase (NSE), and S 100 protein, and was negative for cytokeratins, synaptophysin, chromogranin, neurofilaments, muscle markers, HMB45, and CD34. Ultrastructural study revealed that the tumor had cytoplasmic processes interdigitated in a complex fashion that were held together by primitive junctions but not invested in basal lamina. Many neurosecretory granules and neurotubules were also noted. The diagnosis was GAN tumor of the esophagus. From previous reports, 43 cases (25 males, 18 females) of GAN tumor of other locations have been documented. The tumors were located almost exclusively in the stomach and small intestine: rare cases arose primarily in the retroperitoneum and mesentery. Some of these GAN tumors were observed in patients with Carney's triad (three cases), neurofibromatosis (two cases), and adrenal ganglioneuroma (one case). It appears that the biologic behavior of GAN tumors is aggressive but there are too few reports on which to conclude anything about their prognosis. The tumors are usually large, with low mitotic rate, and are positive for NSE and negative for muscle markers. CONCLUSIONS. To the authors' knowledge, this is the first time that GAN is described in the esophagus. The diagnosis can be made only on the basis of characteristic ultrastructural features.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectautonomic nerve tumoren_HK
dc.subjectesophagusen_HK
dc.subjectimmunohistochemistryen_HK
dc.subjectstromal tumoren_HK
dc.subjectultrastructuralen_HK
dc.titleGastrointestinal autonomic nerve tumor of the esophagus: A clinicopathologic, immunohistochemical, ultrastructural study of a case and review of the literatureen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-543X&volume=78&spage=1651 &epage= 1659&date=1996&atitle=Gastrointestinal+autonomic+nerve+tumour+of+the+esophagus+-+a+clinicopathologic,+immunohistochemical,+ultrastructural+study+of+a+case+and+review+of+the+literatureen_HK
dc.identifier.emailLaw, SYK: slaw@hku.hken_HK
dc.identifier.emailChu, KM: chukm@hkucc.hku.hken_HK
dc.identifier.authorityLaw, SYK=rp00437en_HK
dc.identifier.authorityChu, KM=rp00435en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/(SICI)1097-0142(19961015)78:8<1651::AID-CNCR3>3.0.CO;2-Hen_HK
dc.identifier.pmid8859176-
dc.identifier.scopuseid_2-s2.0-0029763944en_HK
dc.identifier.hkuros26121en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029763944&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume78en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1651en_HK
dc.identifier.epage1659en_HK
dc.identifier.isiWOS:A1996VL24400003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridLaw, SYK=7202241293en_HK
dc.identifier.scopusauthoridChu, KM=7402453538en_HK
dc.identifier.scopusauthoridMa, LT=7403574642en_HK

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