File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A 3-year prospective study of neurological soft signs in first-episode schizophrenia

TitleA 3-year prospective study of neurological soft signs in first-episode schizophrenia
Authors
KeywordsFirst-episode schizophrenia
Longitudinal study
Neurological soft signs
Issue Date2005
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2005, v. 75 n. 1, p. 45-54 How to Cite?
Abstract
Neurological soft signs are biological traits that underlie schizophrenia and are found to occur at higher levels in at-risk individuals. The expression of neurological soft signs may be modifiable during the onset of the first psychotic episode and the subsequent evolution of the illness and its treatment. This study investigates neurological soft signs in 138 patients with first-episode schizophrenia and tracks the expression of motor soft signs in the following 3 years. For the 93 patients who have completed the 3-year follow-up, we find that neurological soft signs are stable in the 3 years that follow the first psychotic episode, and that neurological soft signs are already elevated at the presentation of first-episode psychosis in medication-naïve subjects. The level of neurological soft signs at clinical stabilization is lower for patients with a shorter duration of untreated psychosis. Although the quantity of neurological soft signs does not significantly change in the 3 years that follow the first episode, the relationship between neurological soft signs and negative symptoms does not become apparent until 1 year after the initial episode. A higher level of neurological soft signs is related to a lower educational level and an older age at onset, but the level of neurological soft signs does not predict the outcome in terms of relapse or occupational functioning. © 2004 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/81644
ISSN
2013 Impact Factor: 4.426
2013 SCImago Journal Rankings: 3.163
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorHui, CLMen_HK
dc.contributor.authorChan, RCKen_HK
dc.contributor.authorDunn, ELWen_HK
dc.contributor.authorMiao, MYKen_HK
dc.contributor.authorYeung, WSen_HK
dc.contributor.authorWong, CKen_HK
dc.contributor.authorChan, WFen_HK
dc.contributor.authorTang, WNen_HK
dc.date.accessioned2010-09-06T08:20:16Z-
dc.date.available2010-09-06T08:20:16Z-
dc.date.issued2005en_HK
dc.identifier.citationSchizophrenia Research, 2005, v. 75 n. 1, p. 45-54en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81644-
dc.description.abstractNeurological soft signs are biological traits that underlie schizophrenia and are found to occur at higher levels in at-risk individuals. The expression of neurological soft signs may be modifiable during the onset of the first psychotic episode and the subsequent evolution of the illness and its treatment. This study investigates neurological soft signs in 138 patients with first-episode schizophrenia and tracks the expression of motor soft signs in the following 3 years. For the 93 patients who have completed the 3-year follow-up, we find that neurological soft signs are stable in the 3 years that follow the first psychotic episode, and that neurological soft signs are already elevated at the presentation of first-episode psychosis in medication-naïve subjects. The level of neurological soft signs at clinical stabilization is lower for patients with a shorter duration of untreated psychosis. Although the quantity of neurological soft signs does not significantly change in the 3 years that follow the first episode, the relationship between neurological soft signs and negative symptoms does not become apparent until 1 year after the initial episode. A higher level of neurological soft signs is related to a lower educational level and an older age at onset, but the level of neurological soft signs does not predict the outcome in terms of relapse or occupational functioning. © 2004 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.rightsSchizophrenia Research. Copyright © Elsevier BV.en_HK
dc.subjectFirst-episode schizophreniaen_HK
dc.subjectLongitudinal studyen_HK
dc.subjectNeurological soft signsen_HK
dc.titleA 3-year prospective study of neurological soft signs in first-episode schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-9964&volume=75&spage=45&epage=54&date=2004&atitle=A+3-year+prospective+study+of+neurological+soft+signs+in+first-episode+schizophreniaen_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.schres.2004.09.002en_HK
dc.identifier.pmid15820323en_HK
dc.identifier.scopuseid_2-s2.0-16844382703en_HK
dc.identifier.hkuros98733en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-16844382703&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume75en_HK
dc.identifier.issue1en_HK
dc.identifier.spage45en_HK
dc.identifier.epage54en_HK
dc.identifier.isiWOS:000228617700007-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK
dc.identifier.scopusauthoridHui, CLM=35734149500en_HK
dc.identifier.scopusauthoridChan, RCK=35236280300en_HK
dc.identifier.scopusauthoridDunn, ELW=8610805000en_HK
dc.identifier.scopusauthoridMiao, MYK=8610805100en_HK
dc.identifier.scopusauthoridYeung, WS=8610805200en_HK
dc.identifier.scopusauthoridWong, CK=36862848100en_HK
dc.identifier.scopusauthoridChan, WF=8610805400en_HK
dc.identifier.scopusauthoridTang, WN=8610805700en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats