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Article: A 3-year prospective study of neurological soft signs in first-episode schizophrenia
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TitleA 3-year prospective study of neurological soft signs in first-episode schizophrenia
 
AuthorsChen, EYH1
Hui, CLM1
Chan, RCK1 2
Dunn, ELW3
Miao, MYK3
Yeung, WS3
Wong, CK3
Chan, WF3
Tang, WN3
 
KeywordsFirst-episode schizophrenia
Longitudinal study
Neurological soft signs
 
Issue Date2005
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
 
CitationSchizophrenia Research, 2005, v. 75 n. 1, p. 45-54 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.schres.2004.09.002
 
AbstractNeurological soft signs are biological traits that underlie schizophrenia and are found to occur at higher levels in at-risk individuals. The expression of neurological soft signs may be modifiable during the onset of the first psychotic episode and the subsequent evolution of the illness and its treatment. This study investigates neurological soft signs in 138 patients with first-episode schizophrenia and tracks the expression of motor soft signs in the following 3 years. For the 93 patients who have completed the 3-year follow-up, we find that neurological soft signs are stable in the 3 years that follow the first psychotic episode, and that neurological soft signs are already elevated at the presentation of first-episode psychosis in medication-naïve subjects. The level of neurological soft signs at clinical stabilization is lower for patients with a shorter duration of untreated psychosis. Although the quantity of neurological soft signs does not significantly change in the 3 years that follow the first episode, the relationship between neurological soft signs and negative symptoms does not become apparent until 1 year after the initial episode. A higher level of neurological soft signs is related to a lower educational level and an older age at onset, but the level of neurological soft signs does not predict the outcome in terms of relapse or occupational functioning. © 2004 Elsevier B.V. All rights reserved.
 
ISSN0920-9964
2013 Impact Factor: 4.426
2013 SCImago Journal Rankings: 3.163
 
DOIhttp://dx.doi.org/10.1016/j.schres.2004.09.002
 
ISI Accession Number IDWOS:000228617700007
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChen, EYH
 
dc.contributor.authorHui, CLM
 
dc.contributor.authorChan, RCK
 
dc.contributor.authorDunn, ELW
 
dc.contributor.authorMiao, MYK
 
dc.contributor.authorYeung, WS
 
dc.contributor.authorWong, CK
 
dc.contributor.authorChan, WF
 
dc.contributor.authorTang, WN
 
dc.date.accessioned2010-09-06T08:20:16Z
 
dc.date.available2010-09-06T08:20:16Z
 
dc.date.issued2005
 
dc.description.abstractNeurological soft signs are biological traits that underlie schizophrenia and are found to occur at higher levels in at-risk individuals. The expression of neurological soft signs may be modifiable during the onset of the first psychotic episode and the subsequent evolution of the illness and its treatment. This study investigates neurological soft signs in 138 patients with first-episode schizophrenia and tracks the expression of motor soft signs in the following 3 years. For the 93 patients who have completed the 3-year follow-up, we find that neurological soft signs are stable in the 3 years that follow the first psychotic episode, and that neurological soft signs are already elevated at the presentation of first-episode psychosis in medication-naïve subjects. The level of neurological soft signs at clinical stabilization is lower for patients with a shorter duration of untreated psychosis. Although the quantity of neurological soft signs does not significantly change in the 3 years that follow the first episode, the relationship between neurological soft signs and negative symptoms does not become apparent until 1 year after the initial episode. A higher level of neurological soft signs is related to a lower educational level and an older age at onset, but the level of neurological soft signs does not predict the outcome in terms of relapse or occupational functioning. © 2004 Elsevier B.V. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationSchizophrenia Research, 2005, v. 75 n. 1, p. 45-54 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.schres.2004.09.002
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.schres.2004.09.002
 
dc.identifier.epage54
 
dc.identifier.hkuros98733
 
dc.identifier.isiWOS:000228617700007
 
dc.identifier.issn0920-9964
2013 Impact Factor: 4.426
2013 SCImago Journal Rankings: 3.163
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmid15820323
 
dc.identifier.scopuseid_2-s2.0-16844382703
 
dc.identifier.spage45
 
dc.identifier.urihttp://hdl.handle.net/10722/81644
 
dc.identifier.volume75
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofSchizophrenia Research
 
dc.relation.referencesReferences in Scopus
 
dc.rightsSchizophrenia Research. Copyright © Elsevier BV.
 
dc.subjectFirst-episode schizophrenia
 
dc.subjectLongitudinal study
 
dc.subjectNeurological soft signs
 
dc.titleA 3-year prospective study of neurological soft signs in first-episode schizophrenia
 
dc.typeArticle
 
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<contributor.author>Wong, CK</contributor.author>
<contributor.author>Chan, WF</contributor.author>
<contributor.author>Tang, WN</contributor.author>
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Author Affiliations
  1. The University of Hong Kong
  2. Sun Yat-Sen University
  3. Pamela Youde Nethersole Eastern Hospital