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Article: A prospective 3-year longitudinal study of cognitive predictors of relapse in first-episode schizophrenic patients

TitleA prospective 3-year longitudinal study of cognitive predictors of relapse in first-episode schizophrenic patients
Authors
KeywordsCognitive function
First-episode schizophrenia
Longitudinal
Outcome
Predictors
Relapse
Issue Date2005
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2005, v. 77 n. 1, p. 99-104 How to Cite?
AbstractBackground: Cognitive predictors of relapse have been extensively explored only in few long term longitudinal studies of first-episode schizophrenia. Method: This study prospectively followed 93 patients with first-episode schizophrenia, schizophreniform disorder, and schizoaffective disorder for 3 years after their first-episode illness. Cognitive domains including verbal intelligence, verbal and visual memory, verbal fluency, and Wisconsin Card Sorting Test performance were investigated as potential predictors of relapse. Results: We found that by the first year 21% patients had relapsed, by the second year 33% had relapsed, and by the third year 40% had relapsed. There was a significant difference in the relapse rate between patients with good adherence and patients with poor adherence to medication regimes. A multiple logistic regression analysis revealed that after controlling for medication adherence, perseverative error in the Wisconsin Card Sorting Test was the only cognitive function that significantly predict relapse with an odds ratio of 2.4. Conclusions: Cognitive flexibility in set shifting is related to tendency towards relapse in first-episode schizophrenic patients. Other cognitive factors appear not to be related to relapse. Possible mechanisms included the link between prefrontal dysfunction and sub-cortical dopamine system stability, as well as the effects of executive dysfunction on insight impairment and adherence behavior. © 2005 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/81643
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorHui, CLMen_HK
dc.contributor.authorDunn, ELWen_HK
dc.contributor.authorMiao, MYKen_HK
dc.contributor.authorYeung, WSen_HK
dc.contributor.authorWong, CKen_HK
dc.contributor.authorChan, WFen_HK
dc.contributor.authorTang, WNen_HK
dc.date.accessioned2010-09-06T08:20:15Z-
dc.date.available2010-09-06T08:20:15Z-
dc.date.issued2005en_HK
dc.identifier.citationSchizophrenia Research, 2005, v. 77 n. 1, p. 99-104en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81643-
dc.description.abstractBackground: Cognitive predictors of relapse have been extensively explored only in few long term longitudinal studies of first-episode schizophrenia. Method: This study prospectively followed 93 patients with first-episode schizophrenia, schizophreniform disorder, and schizoaffective disorder for 3 years after their first-episode illness. Cognitive domains including verbal intelligence, verbal and visual memory, verbal fluency, and Wisconsin Card Sorting Test performance were investigated as potential predictors of relapse. Results: We found that by the first year 21% patients had relapsed, by the second year 33% had relapsed, and by the third year 40% had relapsed. There was a significant difference in the relapse rate between patients with good adherence and patients with poor adherence to medication regimes. A multiple logistic regression analysis revealed that after controlling for medication adherence, perseverative error in the Wisconsin Card Sorting Test was the only cognitive function that significantly predict relapse with an odds ratio of 2.4. Conclusions: Cognitive flexibility in set shifting is related to tendency towards relapse in first-episode schizophrenic patients. Other cognitive factors appear not to be related to relapse. Possible mechanisms included the link between prefrontal dysfunction and sub-cortical dopamine system stability, as well as the effects of executive dysfunction on insight impairment and adherence behavior. © 2005 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.rightsSchizophrenia Research. Copyright © Elsevier BV.en_HK
dc.subjectCognitive functionen_HK
dc.subjectFirst-episode schizophreniaen_HK
dc.subjectLongitudinalen_HK
dc.subjectOutcomeen_HK
dc.subjectPredictorsen_HK
dc.subjectRelapseen_HK
dc.titleA prospective 3-year longitudinal study of cognitive predictors of relapse in first-episode schizophrenic patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-9964&volume=77&spage=99&epage=104&date=2005&atitle=A+prospective+3-year+longitudinal+study+of+cognitive+predictors+of+relapse+in+first-episode+schizophrenic+patientsen_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.schres.2005.02.020en_HK
dc.identifier.pmid16005389-
dc.identifier.scopuseid_2-s2.0-21844452950en_HK
dc.identifier.hkuros99449en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-21844452950&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume77en_HK
dc.identifier.issue1en_HK
dc.identifier.spage99en_HK
dc.identifier.epage104en_HK
dc.identifier.isiWOS:000230803600010-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK
dc.identifier.scopusauthoridHui, CLM=35734149500en_HK
dc.identifier.scopusauthoridDunn, ELW=8610805000en_HK
dc.identifier.scopusauthoridMiao, MYK=8610805100en_HK
dc.identifier.scopusauthoridYeung, WS=8610805200en_HK
dc.identifier.scopusauthoridWong, CK=36862848100en_HK
dc.identifier.scopusauthoridChan, WF=8610805400en_HK
dc.identifier.scopusauthoridTang, WN=8610805700en_HK

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