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Article: Myocardial deformation in patients with beta-thalassemia major: A speckle tracking echocardiographic study

TitleMyocardial deformation in patients with beta-thalassemia major: A speckle tracking echocardiographic study
Authors
KeywordsIron load
Myocardial deformation
Speckle tracking echocardiography
Thalassemia
Issue Date2010
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ECHO
Citation
Echocardiography, 2010, v. 27 n. 3, p. 253-259 How to Cite?
AbstractBackground: Increasing data suggest that parameters of myocardial deformation are strong indices of ventricular systolic and diastolic function. We sought to determine myocardial deformation of the left ventricle and assess relationship of deformation rates with myocardial iron load in patients with beta-thalassemia major. Methods: The left ventricular longitudinal, circumferential, and radial myocardial deformation was determined using speckle tracking echocardiography in 42 thalassemia patients aged 24.4 ± 6.4 years. The results were compared with those of 38 age-matched controls. The rates of longitudinal and circumferential deformation were correlated with cardiac T2* magnetic resonance findings. Results: Compared with controls, patients had significantly greater global systolic radial strain (P = 0.001), but similar global systolic longitudinal (P = 0.12) and circumferential strain (P = 0.84). On the other hand, patients had significantly lower longitudinal systolic strain rate (SR) (P = 0.019), longitudinal early diastolic SR (P = 0.036), and circumferential early diastolic SR (P = 0.04) than controls. The cardiac T2* findings correlated positively with longitudinal (r = 0.44, P = 0.004) and circumferential early diastolic SR (r = 0.37, P = 0.019), but not with the respective systolic SRs and left ventricular ejection fraction (all P > 0.05). Patients with iron overload (T2*< 20 msec), compared to those without, had significantly lower longitudinal (1.45 ± 0.33/sec vs. 1.76 ± 0.27/sec, P = 0.002) and circumferential (1.01 ± 0.31/sec vs. 1.22 ± 0.31/sec, P = 0.03) early diastolic SR. Conclusions: Patients with beta-thalassemia major have reduced longitudinal systolic SR, longitudinal early diastolic SR, and circumferential early diastolic SR. The rates of diastolic deformation in the longitudinal and circumferential dimensions are inversely related to myocardial iron overload. © 2010, Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/79907
ISSN
2015 Impact Factor: 1.432
2015 SCImago Journal Rankings: 0.596
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of the Hong Kong Special Administrative Region, ChinaHKU 763307M
Children's Thalassaemia Foundation
Funding Information:

This study was supported by the Research Grants Council of the Hong Kong Special Administrative Region, China (Project no. HKU 763307M) and Children's Thalassaemia Foundation.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorCheung, YFen_HK
dc.contributor.authorLiang, XCen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorWong, SJen_HK
dc.contributor.authorHa, SYen_HK
dc.date.accessioned2010-09-06T08:00:08Z-
dc.date.available2010-09-06T08:00:08Z-
dc.date.issued2010en_HK
dc.identifier.citationEchocardiography, 2010, v. 27 n. 3, p. 253-259en_HK
dc.identifier.issn0742-2822en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79907-
dc.description.abstractBackground: Increasing data suggest that parameters of myocardial deformation are strong indices of ventricular systolic and diastolic function. We sought to determine myocardial deformation of the left ventricle and assess relationship of deformation rates with myocardial iron load in patients with beta-thalassemia major. Methods: The left ventricular longitudinal, circumferential, and radial myocardial deformation was determined using speckle tracking echocardiography in 42 thalassemia patients aged 24.4 ± 6.4 years. The results were compared with those of 38 age-matched controls. The rates of longitudinal and circumferential deformation were correlated with cardiac T2* magnetic resonance findings. Results: Compared with controls, patients had significantly greater global systolic radial strain (P = 0.001), but similar global systolic longitudinal (P = 0.12) and circumferential strain (P = 0.84). On the other hand, patients had significantly lower longitudinal systolic strain rate (SR) (P = 0.019), longitudinal early diastolic SR (P = 0.036), and circumferential early diastolic SR (P = 0.04) than controls. The cardiac T2* findings correlated positively with longitudinal (r = 0.44, P = 0.004) and circumferential early diastolic SR (r = 0.37, P = 0.019), but not with the respective systolic SRs and left ventricular ejection fraction (all P > 0.05). Patients with iron overload (T2*< 20 msec), compared to those without, had significantly lower longitudinal (1.45 ± 0.33/sec vs. 1.76 ± 0.27/sec, P = 0.002) and circumferential (1.01 ± 0.31/sec vs. 1.22 ± 0.31/sec, P = 0.03) early diastolic SR. Conclusions: Patients with beta-thalassemia major have reduced longitudinal systolic SR, longitudinal early diastolic SR, and circumferential early diastolic SR. The rates of diastolic deformation in the longitudinal and circumferential dimensions are inversely related to myocardial iron overload. © 2010, Wiley Periodicals, Inc.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ECHOen_HK
dc.relation.ispartofEchocardiographyen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectIron loaden_HK
dc.subjectMyocardial deformationen_HK
dc.subjectSpeckle tracking echocardiographyen_HK
dc.subjectThalassemiaen_HK
dc.subject.meshDiastole-
dc.subject.meshEchocardiography-
dc.subject.meshHeart Ventricles - ultrasonography-
dc.subject.meshSystole-
dc.subject.meshbeta-Thalassemia - ultrasonography-
dc.titleMyocardial deformation in patients with beta-thalassemia major: A speckle tracking echocardiographic studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0742-2822&volume=27&issue=3&spage=253&epage=259&date=2010&atitle=Myocardial+deformation+in+patients+with+Beta-thalassemia+major:+a+speckle+tracking+echocardiographic+studyen_HK
dc.identifier.emailCheung, YF:xfcheung@hku.hken_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityCheung, YF=rp00382en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1540-8175.2009.01005.xen_HK
dc.identifier.pmid20070362-
dc.identifier.scopuseid_2-s2.0-77949713465en_HK
dc.identifier.hkuros169358en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949713465&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue3en_HK
dc.identifier.spage253en_HK
dc.identifier.epage259en_HK
dc.identifier.isiWOS:000275757300007-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectImpact of Iron Overload on Left Ventricular Torsion in Patients with \xE1-Thalassaemia Major-
dc.identifier.scopusauthoridCheung, YF=7202111067en_HK
dc.identifier.scopusauthoridLiang, XC=12803290200en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridWong, SJ=25924109100en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.citeulike6919156-

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