HKU ResearcherPage: Cheung, YF
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Professor Cheung, Yiu Fai
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Professor Yiu-fai Cheung (張耀輝)
MBBS(HK), MD(HK), MRCP(UK), MRCPCH(UK), FHKCPaed, FHKAM(Paediatrics), FRCPCH(UK), FRCP(Edin)
Clinical Professor, Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong
Sir Patrick Manson Gold Medal (2004)
Faculty Teaching Medal (2007)
Dr Yiu-fai Cheung is a clinician specializing in paediatric cardiology, a teacher, and a clinician investigator. His research interests include ventricular function in congenital and acquired heart diseases, vascular health, and ventriculo-arterial interaction. He has written more than 100 peer-reviewed papers, 2 books, and 8 book chapters, produced a multimedia CD-ROM on diagnosis of congenital heart disease, and delivered more than 80 invited lectures. Dr Cheung graduated from The University of Hong Kong in 1990, received his Doctorate of Medicine in 2004, and became a full professor in The University of Hong Kong in 2007. In recognition of his excellence in medical education, he was awarded the Faculty Teaching Medal in 2007. He is currently Clinical Professor, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Paediatric cardiology and adult congenital heart disease are the major areas of Professor Cheung's research. The scope of research encompasses three domains: (i) paediatric and adult congenital heart disease, (ii) acquired heart disease in children, and (iii) vascular function in health and disease in the young. His research work focuses on the followings:
- Clinical translation and applications of novel echocardiographic imaging technologies
- Cardiac and vascular mechanics in paediatric and adult congenital heart disease, iron overload and chemotherapy toxicity
- Circulating biomarkers in congenital heart disease
- Long-term clinical outcomes of paediatric congenital heart patients
- Kawasaki disease: genetics and vascular health
At the Faculty level, Professor Cheung is Chairman of the Board of Studies of Master of Medical Sciences programme. At the Departmental level, he is member of the Education Committee and helps to coordinate undergraduate teachings of medical students. Externally, he is member of the Examination Committee of Hong Kong College of Paediatricians. He serves as examiner of the MBBS examinations, MRCPCH clinical examination, and Licensing Examination of the Medical Council of Hong Kong. Professor YF Cheung is responsible for the teaching of paediatric cardiology to medical students, paediatric residents, and cardiology fellows.
Professor YF Cheung provides specialist clinical service for children and adults with congenital and children with acquired heart diseases. Together with other paediatric cardiologists atQueen Mary Hospital, they provide comprehensive diagnostic evaluation, postoperative care, and transcatheter interventions for patients ranging from neonates with critical heart conditions to grown-up congenital heart patients.
Four Recent Highlighted Publications
1. Khor CC, Davila S, Breunis WB, Lee YC, Shimizu C, Wright VJ, Yeung RS, Tan DE, Sim KS, Wang JJ, Wong TY, Pang J, Mitchell P, Cimaz R, Dahdah N, Cheung YF, Huang GY, Yang W, Park IS, Lee JK, Wu JY, Levin M, Burns JC, Burgner D, Kuijpers TW, Hibberd ML; Hong Kong–Shanghai Kawasaki Disease Genetics Consortium, Lau YL, Zhang J, Ma XJ, Liu F, Wu L; Korean Kawasaki Disease Genetics Consortium, Yoo JJ, Hong SJ, Kim KJ, Kim JJ, Park YM, Hong YM, Sohn S, Jang GY, Ha KS, Nam HK, Byeon JH, Yun SW, Han MK, Lee KY, Hwang JY, Rhim JW, Song MS, Lee HD, Kim DS, Lee JM; Taiwan Kawasaki Disease Genetics Consortium, Chang JS, Tsai FJ, Liang CD, Chen MR, Chi H, Chiu NC, Huang FY, Chang LY, Huang LM, Kuo HC, Huang KP, Lee ML, Hwang B, Huang YC, Lee PC; International Kawasaki Disease Genetics Consortium, Odam M, Christiansen FT, Witt C, Goldwater P, Curtis N, Palasanthiran P, Ziegler J, Nissen M, Nourse C, Kuipers IM, Ottenkamp JJ, Geissler J, Biezeveld M, Tacke C, Filippini L, Brogan P, Klein N, Shah V, Dillon M, Booy R, Shingadia D, Bose A, Mukasa T, Tulloh R, Michie C; US Kawasaki Disease Genetics Consortium, Newburger JW, Baker AL, Rowley AH, Shulman ST, Mason W, Takahashi M, Melish ME, Tremoulet AH; Blue Mountains Eye Study, Viswanathan A, Rochtchina E, Attia J, Scott R, Holliday E, Harrap S. Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nature Genetics 2011;43:1241-1246.
This piece of work, a case-control genome-wide association study of Kawasaki disease and replication analysis in 2,173 patients and 9,383 controls from five independent sample collections, provided novel genetic insights into the pathogenesis of Kawasaki disease. Identification of a functional polymorphism in the IgG receptor gene FCGR2A has important implications on understanding immune activation in disease pathogenesis and the mechanism of response to intravenous immunoglobulin, the only proven therapy for this disease. Dr Cheung is the principal investigator of the Hong Kong-Shanghai Kawasaki Disease Genetics Consortium responsible for validation of results in Han Chinese population.
2. Cheung YF, Huang GY, Chen SB, Liu XQ, Xi L, Liang XC, Huang MR, Chen S, Huang LS, Liu XQ, Chan KW, Lau YL. Inflammatory gene polymorphisms and susceptibility to Kawasaki disease and its arterial sequelae. Pediatrics 2008;122:608-614.
This piece of work described novel findings on associations between inflammatory gene polymorphisms and late systemic arterial dysfunction in children with a history of Kawasaki disease. Dr Cheung led this multi-centre study to look from a new perspective on possible genotype-modulating effect on late systemic arterial dysfunction in this vasculitic disease prevalent in the locality. The findings suggested interactions between genetic programming of the dynamic response of inflammatory stimuli and exogenous vasculitic stress, and added insights on understanding of genetics of arterial stiffness.
3. Chow PC, Liang XC, Cheung EW, Lam WW, Cheung YF. New Two-Dimensional Global Longitudinal Strain and Strain Rate Imaging for Assessment of Systemic Right Ventricular Function. Heart 2008, 94: 855-859.
This piece of work represents a pioneering application of the non-invasive two-dimensional speckle tracking technique in assessing right ventricular function, which is of paramount importance in the follow-up of paediatric and adult patients with congenital heart problems. Assessment of right ventricular function is inherently difficult. This study provided the first evidence of reproducibility and usefulness of the speckle tracking technology compared with the gold-standard cardiac magnetic resonance.
4. Yu HK, Yu W, Cheuk DK, Wong SJ, Chan GC, Cheung YF. New Three-Dimensional Speckle-Tracking Echocardiography Identifies Global Impairment of Left Ventricular Mechanics with a High Sensitivity in Childhood Cancer Survivors. J Am Soc Echocardiogr. 2013;26:846-852.
This piece of work described a novel application of the new three-dimensional speckle-tracking echocardiographic technique in the early identification of subclinical anthracycline cardiotoxicity in childhood cancer survivors. This study proposed a new concept of assessing global ventricular performance by derivation of a composite index that takes into account of three important myocardial mechanical elements, namely deformation, torsion and dyssynchrony.
Honours, Awards & Prizes
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