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Professor Cheung, Yiu Fai 張耀輝

Title:
Clinical Professor
Bryan Lin Professorship in Paediatric Cardiology

Biography
Professor Yiu-fai Cheung (張耀)
MBBS(HK), MD(HK), MRCP(UK), MRCPCH(UK), FHKCPaed, FHKAM(Paediatrics), FRCPCH(UK), FRCP(Edin)
 
Clinical Professor, Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong
 
Specialty
Paediatric Cardiology
 
Awards
Sir Patrick Manson Gold Medal (2004)
Faculty Teaching Medal (2007)
 
Biosketch
Dr Yiu-fai Cheung is a clinician specializing in paediatric cardiology, a teacher, and a clinician investigator.  His research interests include ventricular function in congenital and acquired heart diseases, vascular health, and ventriculo-arterial interaction.  He has written more than 100 peer-reviewed papers, 2 books, and 8 book chapters, produced a multimedia CD-ROM on diagnosis of congenital heart disease, and delivered more than 80 invited lectures.  Dr Cheung graduated from The University of Hong Kong in 1990, received his Doctorate of Medicine in 2004, and became a full professor in The University of Hong Kong in 2007.  In recognition of his excellence in medical education, he was awarded the Faculty Teaching Medal in 2007.  He is currently Clinical Professor, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
 
Research areas
Paediatric cardiology and adult congenital heart disease are the major areas of Professor Cheung's research.  The scope of research encompasses three domains: (i) paediatric and adult congenital heart disease, (ii) acquired heart disease in children, and (iii) vascular function in health and disease in the young.  His research work focuses on the followings:
  • Clinical translation and applications of novel echocardiographic imaging technologies
  • Cardiac and vascular mechanics in paediatric and adult congenital heart disease, iron overload and chemotherapy toxicity
  • Circulating biomarkers in congenital heart disease
  • Long-term clinical outcomes of paediatric congenital heart patients
  • Kawasaki disease: genetics and vascular health
 
Education
At the Faculty level, Professor Cheung is Chairman of the Board of Studies of Master of Medical Sciences programme.  At the Departmental level, he is member of the Education Committee and helps to coordinate undergraduate teachings of medical students.  Externally, he is member of the Examination Committee of Hong Kong College of Paediatricians. He serves as examiner of the MBBS examinations, MRCPCH clinical examination, and Licensing Examination of the Medical Council of Hong Kong. Professor YF Cheung is responsible for the teaching of paediatric cardiology to medical students, paediatric residents, and cardiology fellows.
 
Clinical Service
Professor YF Cheung provides specialist clinical service for children and adults with congenital and children with acquired heart diseasesTogether with other paediatric cardiologists atQueen Mary Hospital, they provide comprehensive diagnostic evaluation, postoperative care, and transcatheter interventions for patients ranging from neonates with critical heart conditions to grown-up congenital heart patients.
 


Four Recent Highlighted Publications

 
1.    Khor CC, Davila S, Breunis WB, Lee YC, Shimizu C, Wright VJ, Yeung RS, Tan DE, Sim KS, Wang JJ, Wong TY, Pang J, Mitchell P, Cimaz R, Dahdah N, Cheung YF, Huang GY, Yang W, Park IS, Lee JK, Wu JY, Levin M, Burns JC, Burgner D, Kuijpers TW, Hibberd ML; Hong Kong–Shanghai Kawasaki Disease Genetics Consortium, Lau YL, Zhang J, Ma XJ, Liu F, Wu L; Korean Kawasaki Disease Genetics Consortium, Yoo JJ, Hong SJ, Kim KJ, Kim JJ, Park YM, Hong YM, Sohn S, Jang GY, Ha KS, Nam HK, Byeon JH, Yun SW, Han MK, Lee KY, Hwang JY, Rhim JW, Song MS, Lee HD, Kim DS, Lee JM; Taiwan Kawasaki Disease Genetics Consortium, Chang JS, Tsai FJ, Liang CD, Chen MR, Chi H, Chiu NC, Huang FY, Chang LY, Huang LM, Kuo HC, Huang KP, Lee ML, Hwang B, Huang YC, Lee PC; International Kawasaki Disease Genetics Consortium, Odam M, Christiansen FT, Witt C, Goldwater P, Curtis N, Palasanthiran P, Ziegler J, Nissen M, Nourse C, Kuipers IM, Ottenkamp JJ, Geissler J, Biezeveld M, Tacke C, Filippini L, Brogan P, Klein N, Shah V, Dillon M, Booy R, Shingadia D, Bose A, Mukasa T, Tulloh R, Michie C; US Kawasaki Disease Genetics Consortium, Newburger JW, Baker AL, Rowley AH, Shulman ST, Mason W, Takahashi M, Melish ME, Tremoulet AH; Blue Mountains Eye Study, Viswanathan A, Rochtchina E, Attia J, Scott R, Holliday E, Harrap S. Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nature Genetics 2011;43:1241-1246.
 
This piece of work, a case-control genome-wide association study of Kawasaki disease and replication analysis in 2,173 patients and 9,383 controls from five independent sample collections, provided novel genetic insights into the pathogenesis of Kawasaki disease.  Identification of a functional polymorphism in the IgG receptor gene FCGR2A has important implications on understanding immune activation in disease pathogenesis and the mechanism of response to intravenous immunoglobulin, the only proven therapy for this disease.  Dr Cheung is the principal investigator of the Hong Kong-Shanghai Kawasaki Disease Genetics Consortium responsible for validation of results in Han Chinese population.
 
2.    Cheung YF, Huang GY, Chen SB, Liu XQ, Xi L, Liang XC, Huang MR, Chen S, Huang LS, Liu XQ, Chan KW, Lau YL. Inflammatory gene polymorphisms and susceptibility to Kawasaki disease and its arterial sequelae. Pediatrics 2008;122:608-614.
 
This piece of work described novel findings on associations between inflammatory gene polymorphisms and late systemic arterial dysfunction in children with a history of Kawasaki disease.  Dr Cheung led this multi-centre study to look from a new perspective on possible genotype-modulating effect on late systemic arterial dysfunction in this vasculitic disease prevalent in the locality.  The findings suggested interactions between genetic programming of the dynamic response of inflammatory stimuli and exogenous vasculitic stress, and added insights on understanding of genetics of arterial stiffness.
 
3.    Chow PC, Liang XC, Cheung EW, Lam WW, Cheung YF. New Two-Dimensional Global Longitudinal Strain and Strain Rate Imaging for Assessment of Systemic Right Ventricular Function. Heart 2008, 94: 855-859.
 
This piece of work represents a pioneering application of the non-invasive two-dimensional speckle tracking technique in assessing right ventricular function, which is of paramount importance in the follow-up of paediatric and adult patients with congenital heart problems.  Assessment of right ventricular function is inherently difficult.  This study provided the first evidence of reproducibility and usefulness of the speckle tracking technology compared with the gold-standard cardiac magnetic resonance.
 
4.    Yu HK, Yu W, Cheuk DK, Wong SJ, Chan GC, Cheung YF. New Three-Dimensional Speckle-Tracking Echocardiography Identifies Global Impairment of Left Ventricular Mechanics with a High Sensitivity in Childhood Cancer Survivors. J Am Soc Echocardiogr. 2013;26:846-852.
 
This piece of work described a novel application of the new three-dimensional speckle-tracking echocardiographic technique in the early identification of subclinical anthracycline cardiotoxicity in childhood cancer survivors.  This study proposed a new concept of assessing global ventricular performance by derivation of a composite index that takes into account of three important myocardial mechanical elements, namely deformation, torsion and dyssynchrony.
 
Honours, Awards & Prizes
AwardeesAward DateHonours / Awards / PrizesCategory
2013-01-01上海市科學技術獎二等獎, 研究項目:川崎病冠狀動脈病變的流行病學臨床處理及預測指標研究
Research Achievement
Kwok, KL
Ng, DKK
2001-10-13Primary Snoring: Systemic Blood Pressure and Arterial Distensibility in Children (best paper, oral presentation): Joint Annual Scientific Meeting 2001, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Hong Kong, 13 October 2001 (Best paper award, oral presentation)
Research Achievement
Chiu, CSW
Yung, TC
Chau, AKT
2001-12-01Impact of Preoperative Aortic Cusp Prolapse on Long-Term Outcome After Surgical Closure of Subarterial Ventricular Septal Defect (best paper, oral presentation): The Fifth Annual Scientific Meeting, Institute of Cardiovascular Science and Medicine (Abstract in Journal of the Hong Kong College of Cardiology), Hong Kong, 1-2 December 2001 (Best paper award, oral presentation)
Research Achievement
Cheung, EWY
Chau, AKT
2005-10-01Plasma brain natriuretic peptide relates to pulmonary regurgitation after tetralogy of Fallot repair (Travel award): 1st Congress of Asian Society for Pediatric Research, Tokyo, Japan
Research Achievement
Ha, SY
2002-10-26Arterial Stiffness and Endothelial Function in Patients with Beta-thalassaemia Major. (Second Prize, oral presentation): Joint Scientific Meeting, Hong Kong College of Physicians & Hong Kong College of Paediatricians, Hong Kong, 26-27 October 2002
Research Achievement
2004-10-01Elevated Hs-CRP Levels and Increased Arterial Stiffness in Children with a History of Kawasaki Disease (Second best poster): 5th Guangdong Hong Kong Paediatric Exchange Meeting, Hong Kong
Research Achievement
Hou, J
2013-07-01Travel Award (supervisor of Dr Hou Jia) Atrial Mechanics in Patients After Surgical Repair of Tetralogy of Fallot: The 49th Annual Meeting of Japanese Society of Pediatric Cardiology and Cardiac Surgery
Research Achievement
2007-09-01Faculty Teaching Medal: Li Ka Shing Faculty of Medicine, The University of Hong Kong
Research Achievement
2013-12-01中華醫學科技獎, 川崎病冠狀動脈病變的流行病學臨床處理及預測指標研究
Research Achievement
2010-07-01Young Investigator Award (supervisor of Dr Carline Koh): Impact of right ventricular pacing on left ventricular torsion in children with congenital heart block: The 3rd Congress of Asia-Pacific Society of Pediatric Cardiology and Cardiac Surgery, Tokyo, Japan
Research Achievement
2004-10-01An analysis of the determinants of peripheral conduit arterial stiffness in children and teenagers in health and disease (Sir Patrick Manson Gold Medal, for the best MD thesis of the year): University of Hong Kong for the degree of Doctor of Medicine
Research Achievement
Huang, GY
Chen, SB
Liu, XQ
Li, X
Liang, XC
Huang, MR
Chen, S
Huang, LS
Liu, XQ
Chan, KW
2008-06-28Best poster presentation: Inflammatory Gene Polymorphisms and Susceptibility to Kawasaki Disease and Its Arterial Sequelae: 7th Guangdong - Hong Kong & 1st Hong Kong - Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, Hong Kong, 28 June 2008
Teaching Accomplishment
2009-05-01Young Investigator Award of fellow Dr PC Chow: Diastolic ventricular interaction in patients after atrial switch for transposition of the great arteries: 5th Congress of Asian Society for Paediatric Research, Hangzhou, PR China
Research Achievement
2014-05-01Highest ranking abstract submitted from Hong Kong “Cardiac magnetic resonance assessment of myocardial iron load and fibrosis in adult survivors of childhood leukaemias”: American College of Cardiology’s Annual Scientific Sessions in Washington, DC.
Research Achievement
2003-10-01Novel and traditional cardiovascular risk factors in children after Kawasaki disease (Second best paper): Joint Annual Scientific Meeting for Paediatricians and Pediatric Nurses, Hong Kong Paediatric Society, Hong Kong
Research Achievement
Karmin, O
Tam, S
Siow, YL
2005-04-24Induction of MCP1, CCR2 and iNOS Expression in THP-1 Macrophages by Serum of Children Late After Kawasaki Disease (Best paper, oral prestentation): 13th Annual Scientific Congress of Hong Kong College of Cardiology (abstract published in the Journal of the Hong Kong College of Cardiology), 22-24 April 2005 (Best paper award, oral presentation)
Research Achievement
2008-05-30Seijong Young Investigator Award of fellow Dr Eddie Cheung: Impact of Right Ventricular Dilation of Left Ventricular Myocardial Deformation in Patients after Surgical Repair of Tetralogy of Fallot: The 2nd Asia-Pacific Congress of Pediatric Cardiology and Cardiac Surgery, Jeju, Korea, 27-30 May 2008
Research Achievement
Chen, M
Chan, S
Yang, M
2010-04-01Travel Award (supervisor of MMed Sc student; Chen Meipian): Iron overload induced apoptosis in HL-1 cardiomyocytes via mitochondria-mediated caspase-3 dependent pathways: The 6th Congress of Asian Society for Pediatric Research & 51st Annual Meeting of Taiwan Pediatric Association. Taipei, Taiwan, PR China 2010.
Research Achievement
Professional Societies
Term PeriodPositionProfessional Societies
2011-nowEducation and Accreditation Committee MemberThe Medical Council of Hong Kong
2005-nowMemberInstitute Review Board, Hong Kong West Cluster and The University of Hong Kong
2002-2006Honorary TreasurerInstitute of Cardiovascular Science and Medicine/HKU
1999-2006Council memberInstitute of Cardiovascular Science and Medicine/HKU
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