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Article: A new haplotype of PDCD1 is associated with rheumatoid arthritis in Hong Kong Chinese

TitleA new haplotype of PDCD1 is associated with rheumatoid arthritis in Hong Kong Chinese
Authors
Issue Date2005
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0004-3591/
Citation
Arthritis And Rheumatism, 2005, v. 52 n. 4, p. 1058-1062 How to Cite?
AbstractObjective. The programmed death 1 (PD-1) molecule is a negative regulator of T cells, and a genetic association between PD-1 and systemic lupus erythematosus and rheumatoid arthritis (RA) in Caucasians has been reported. The aim of this study was to investigate the association of PDCD1 polymorphisms and haplotypes with RA in the Chinese population. Methods. Three single-nucleotide polymorphisms (SNPs), PD-1.1 G/A, PD-1.3 G/A, and PD-1.5 C/T, were genotyped in 180 patients with MA and 647 healthy controls in a case-control association study. Analyses of the association of genotypes and alleles with disease, haplotype construction, and linkage disequilibrium (LD) were performed. Results. We constructed haplotypes with the alleles of markers PD-1.1 G/A and PD-1.5 C/T and found that the GT haplotype was overrepresented in patients with RA (31%) compared with controls (23%) (P = 0.001, odds ratio [OR] 1.54, 95% confidence interval [95% CI] 1.18-1.99). Among GT double homozygotes the risk of RA was increased even further (OR 2.31, 95% CI 1.31-4.08, P = 0.006). We also observed that the AA genotype of SNP PD-1.1 was associated with a decreased risk for developing RA (OR 0.38, 95% CI 0.15-0.99, P = 0.034). No association for SNP PD-1.5 in RA was found, and SNP PD-1.3 was nonpolymorphic in the Chinese population. Conclusion. Our results support the involvement of PDCD1 as a susceptibility gene for RA in the Chinese population. © 2005, American College of Rheumatology.
Persistent Identifierhttp://hdl.handle.net/10722/79900
ISSN
2015 Impact Factor: 8.955
2015 SCImago Journal Rankings: 3.206
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKong, EKPen_HK
dc.contributor.authorProkuninaOlsson, Len_HK
dc.contributor.authorWong, WHSen_HK
dc.contributor.authorLau, CSen_HK
dc.contributor.authorChan, TMen_HK
dc.contributor.authorAlarcónRiquelme, Men_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-06T08:00:00Z-
dc.date.available2010-09-06T08:00:00Z-
dc.date.issued2005en_HK
dc.identifier.citationArthritis And Rheumatism, 2005, v. 52 n. 4, p. 1058-1062en_HK
dc.identifier.issn0004-3591en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79900-
dc.description.abstractObjective. The programmed death 1 (PD-1) molecule is a negative regulator of T cells, and a genetic association between PD-1 and systemic lupus erythematosus and rheumatoid arthritis (RA) in Caucasians has been reported. The aim of this study was to investigate the association of PDCD1 polymorphisms and haplotypes with RA in the Chinese population. Methods. Three single-nucleotide polymorphisms (SNPs), PD-1.1 G/A, PD-1.3 G/A, and PD-1.5 C/T, were genotyped in 180 patients with MA and 647 healthy controls in a case-control association study. Analyses of the association of genotypes and alleles with disease, haplotype construction, and linkage disequilibrium (LD) were performed. Results. We constructed haplotypes with the alleles of markers PD-1.1 G/A and PD-1.5 C/T and found that the GT haplotype was overrepresented in patients with RA (31%) compared with controls (23%) (P = 0.001, odds ratio [OR] 1.54, 95% confidence interval [95% CI] 1.18-1.99). Among GT double homozygotes the risk of RA was increased even further (OR 2.31, 95% CI 1.31-4.08, P = 0.006). We also observed that the AA genotype of SNP PD-1.1 was associated with a decreased risk for developing RA (OR 0.38, 95% CI 0.15-0.99, P = 0.034). No association for SNP PD-1.5 in RA was found, and SNP PD-1.3 was nonpolymorphic in the Chinese population. Conclusion. Our results support the involvement of PDCD1 as a susceptibility gene for RA in the Chinese population. © 2005, American College of Rheumatology.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0004-3591/en_HK
dc.relation.ispartofArthritis and Rheumatismen_HK
dc.rightsArthritis & Rheumatism. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAntigens, CDen_HK
dc.subject.meshAntigens, Surface - geneticsen_HK
dc.subject.meshApoptosis Regulatory Proteinsen_HK
dc.subject.meshArthritis, Rheumatoid - ethnology - geneticsen_HK
dc.subject.meshChina - ethnologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGenetic Predisposition to Diseaseen_HK
dc.subject.meshHaplotypes - geneticsen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLinkage Disequilibriumen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPolymorphism, Single Nucleotideen_HK
dc.subject.meshProgrammed Cell Death 1 Receptoren_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.titleA new haplotype of PDCD1 is associated with rheumatoid arthritis in Hong Kong Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0004-3591&volume=52&issue=4&spage=1058&epage=1062&date=2005&atitle=A+New+Haplotype+of+PDCD1+is+Associated+with+Rheumatoid+Arthritis+in+Hong+Kong+Chineseen_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.emailChan, TM:dtmchan@hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/art.20966en_HK
dc.identifier.pmid15818672-
dc.identifier.scopuseid_2-s2.0-17244383354en_HK
dc.identifier.hkuros97696en_HK
dc.identifier.hkuros117903-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17244383354&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume52en_HK
dc.identifier.issue4en_HK
dc.identifier.spage1058en_HK
dc.identifier.epage1062en_HK
dc.identifier.isiWOS:000228688200009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKong, EKP=8617703100en_HK
dc.identifier.scopusauthoridProkuninaOlsson, L=16426739500en_HK
dc.identifier.scopusauthoridWong, WHS=13310222200en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK
dc.identifier.scopusauthoridAlarcónRiquelme, M=7004201121en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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