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Article: Relation of arterial stiffness to left ventricular structure and function in adolescents and young adults with pediatric-onset systemic lupus erythematosus

TitleRelation of arterial stiffness to left ventricular structure and function in adolescents and young adults with pediatric-onset systemic lupus erythematosus
Authors
KeywordsArterial stiffness
Left ventricle
Systemic lupus erythematosus
Issue Date2007
PublisherJournal of Rheumatology Publishing Co Ltd. The Journal's web site is located at http://www.jrheum.com
Citation
Journal Of Rheumatology, 2007, v. 34 n. 6, p. 1345-1352 How to Cite?
AbstractObjective. Limited adult data suggested arterial stiffening in systemic lupus erythematosus (SLE). We investigated the hypothesis that arterial stiffening is related to left ventricular (LV) structure and function in adolescents and young adults with pediatric-onset SLE. Methods. We studied 32 patients with SLE (28 female) aged 17.3 ± 4.8 years. The arterial stiffness was assessed by the carotid artery stiffness index, while the LV mass and cardiac function were assessed echocardiographically. These indices were compared to those of 15 healthy controls. Results. Compared with controls, patients with SLE had lower LV shortening fraction, ejection fraction and mean velocity of circumferential fiber shortening, reduced mitral early diastolic inflow velocity and early (em) diastolic myocardial tissue velocity, and lower systolic strain and systolic and diastolic strain rates of the LV free wall (all p ≤ 0.02). Their global LV function was impaired as reflected by the significantly higher myocardial performance index (MPI; p = 0.02). The carotid arterial stiffness index (p < 0.001) and LV mass (p < 0.001) were significantly greater in patients than controls. Among patients with SLE, the carotid arterial stiffness index correlated with disease activity index (r = 0.46, p = 0.009). Multivariate analysis revealed that carotid arterial stiffness was a significant independent determinant of LV mass (β = 0.52, p < 0.001), MPI (β = 0.43, p = 0.002), em velocity (β = -0.46, p = 0.001), and systolic strain rate of the LV free wall (β = -0.46, p = 0.001). Conclusion. Arterial stiffening occurs in adolescents and young adults with SLE, which may contribute to the development of LV hypertrophy and subclinical myocardial dysfunction.
Persistent Identifierhttp://hdl.handle.net/10722/79895
ISSN
2015 Impact Factor: 3.236
2015 SCImago Journal Rankings: 1.225
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChow, PCen_HK
dc.contributor.authorHo, MHKen_HK
dc.contributor.authorLee, TLen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorCheung, YFen_HK
dc.date.accessioned2010-09-06T07:59:57Z-
dc.date.available2010-09-06T07:59:57Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Rheumatology, 2007, v. 34 n. 6, p. 1345-1352en_HK
dc.identifier.issn0315-162Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/79895-
dc.description.abstractObjective. Limited adult data suggested arterial stiffening in systemic lupus erythematosus (SLE). We investigated the hypothesis that arterial stiffening is related to left ventricular (LV) structure and function in adolescents and young adults with pediatric-onset SLE. Methods. We studied 32 patients with SLE (28 female) aged 17.3 ± 4.8 years. The arterial stiffness was assessed by the carotid artery stiffness index, while the LV mass and cardiac function were assessed echocardiographically. These indices were compared to those of 15 healthy controls. Results. Compared with controls, patients with SLE had lower LV shortening fraction, ejection fraction and mean velocity of circumferential fiber shortening, reduced mitral early diastolic inflow velocity and early (em) diastolic myocardial tissue velocity, and lower systolic strain and systolic and diastolic strain rates of the LV free wall (all p ≤ 0.02). Their global LV function was impaired as reflected by the significantly higher myocardial performance index (MPI; p = 0.02). The carotid arterial stiffness index (p < 0.001) and LV mass (p < 0.001) were significantly greater in patients than controls. Among patients with SLE, the carotid arterial stiffness index correlated with disease activity index (r = 0.46, p = 0.009). Multivariate analysis revealed that carotid arterial stiffness was a significant independent determinant of LV mass (β = 0.52, p < 0.001), MPI (β = 0.43, p = 0.002), em velocity (β = -0.46, p = 0.001), and systolic strain rate of the LV free wall (β = -0.46, p = 0.001). Conclusion. Arterial stiffening occurs in adolescents and young adults with SLE, which may contribute to the development of LV hypertrophy and subclinical myocardial dysfunction.en_HK
dc.languageengen_HK
dc.publisherJournal of Rheumatology Publishing Co Ltd. The Journal's web site is located at http://www.jrheum.comen_HK
dc.relation.ispartofJournal of Rheumatologyen_HK
dc.subjectArterial stiffnessen_HK
dc.subjectLeft ventricleen_HK
dc.subjectSystemic lupus erythematosusen_HK
dc.titleRelation of arterial stiffness to left ventricular structure and function in adolescents and young adults with pediatric-onset systemic lupus erythematosusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0315-162X&volume=34&issue=6&spage=1345&epage=1352&date=2007&atitle=Relation+of+Arterial+Stiffness+to+Left+Ventricular+Structure+and+Function+in+Adolescents+and+Young+Adults+with+Pediatric-Onset+Systemic+Lupus+Erythematosusen_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.emailCheung, YF:xfcheung@hku.hken_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityCheung, YF=rp00382en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid17477468-
dc.identifier.scopuseid_2-s2.0-34250199407en_HK
dc.identifier.hkuros127696en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34250199407&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1345en_HK
dc.identifier.epage1352en_HK
dc.identifier.isiWOS:000247116600024-
dc.publisher.placeCanadaen_HK
dc.identifier.scopusauthoridChow, PC=23099233800en_HK
dc.identifier.scopusauthoridHo, MHK=8925896400en_HK
dc.identifier.scopusauthoridLee, TL=8508917400en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridCheung, YF=7202111067en_HK

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