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Article: Association of interleukin-10 promoter polymorphisms with systemic lupus erythematosus

TitleAssociation of interleukin-10 promoter polymorphisms with systemic lupus erythematosus
Authors
KeywordsHaplotype
Interleukin 10
Polymorphism
Systemic lupus erythematosus
Issue Date2004
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/gene
Citation
Genes And Immunity, 2004, v. 5 n. 6, p. 484-492 How to Cite?
AbstractSeveral lines of evidence suggest interleukin-10 gene (IL-10) is a candidate gene in susceptibility to systemic lupus erythematosus (SLE). We investigated the association of IL-10 promoter single-nucleotide polymorphisms (SNPs) (-3575T/A, -2849G/A, -2763C/A, -1082A/G, -819T/C and -592A/C) and microsatellites (IL10.R, 1L10.G) with SLE in 554 Hong Kong Chinese patients and 708 ethnically matched controls. Six haplotypes (hts) were identified from the SNPs. The genotype distribution of the ht1 (T-C-A-T-A), which is associated with low IL-10 production, was different in patients and controls (P = 0.009). The homozygous genotype of non-ht1 was significantly increased in patients (P = 0.009, odds ratio (OR) = 1.80, 95% CI: 1.15-2.82). The frequency of IL10.G4 of IL10.G was also significantly increased in patients (P = 0.017, OR = 2.53, 95% CI: 1.18-5.40). We found that the homozygous non-ht1 combined with short allele (CA repeat number ≤21) of 1L10.G has a dose-dependent effect on SLE susceptibility: non-ht1/non-ht1 with homozygous short allele showed a higher OR (OR = 4.11, 95% CI: 1.27-13.2, P = 0.018) of association with SLE than the genotype of non-ht1/non-ht1 with heterozygous short/long allele (OR = 2.98, 95% CI: 1.26-7.07, P = 0.013) and homozygous long allele (OR = 1.05, 95% CI: 0.62-1.78, P = 0.848). The frequency of non-ht1 was significantly increased in patients with serositis (P < 0.0001, OR = 2.42, 95% CI: 1.55-3.80). In conclusion, the high expression promoter genotype is associated with SLE in Chinese. © 2004 Nature Publishing Group All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/79857
ISSN
2015 Impact Factor: 2.472
2015 SCImago Journal Rankings: 1.636
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChong, WPen_HK
dc.contributor.authorIp, WKen_HK
dc.contributor.authorWong, WHSen_HK
dc.contributor.authorLau, CSen_HK
dc.contributor.authorChan, TMen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-06T07:59:32Z-
dc.date.available2010-09-06T07:59:32Z-
dc.date.issued2004en_HK
dc.identifier.citationGenes And Immunity, 2004, v. 5 n. 6, p. 484-492en_HK
dc.identifier.issn1466-4879en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79857-
dc.description.abstractSeveral lines of evidence suggest interleukin-10 gene (IL-10) is a candidate gene in susceptibility to systemic lupus erythematosus (SLE). We investigated the association of IL-10 promoter single-nucleotide polymorphisms (SNPs) (-3575T/A, -2849G/A, -2763C/A, -1082A/G, -819T/C and -592A/C) and microsatellites (IL10.R, 1L10.G) with SLE in 554 Hong Kong Chinese patients and 708 ethnically matched controls. Six haplotypes (hts) were identified from the SNPs. The genotype distribution of the ht1 (T-C-A-T-A), which is associated with low IL-10 production, was different in patients and controls (P = 0.009). The homozygous genotype of non-ht1 was significantly increased in patients (P = 0.009, odds ratio (OR) = 1.80, 95% CI: 1.15-2.82). The frequency of IL10.G4 of IL10.G was also significantly increased in patients (P = 0.017, OR = 2.53, 95% CI: 1.18-5.40). We found that the homozygous non-ht1 combined with short allele (CA repeat number ≤21) of 1L10.G has a dose-dependent effect on SLE susceptibility: non-ht1/non-ht1 with homozygous short allele showed a higher OR (OR = 4.11, 95% CI: 1.27-13.2, P = 0.018) of association with SLE than the genotype of non-ht1/non-ht1 with heterozygous short/long allele (OR = 2.98, 95% CI: 1.26-7.07, P = 0.013) and homozygous long allele (OR = 1.05, 95% CI: 0.62-1.78, P = 0.848). The frequency of non-ht1 was significantly increased in patients with serositis (P < 0.0001, OR = 2.42, 95% CI: 1.55-3.80). In conclusion, the high expression promoter genotype is associated with SLE in Chinese. © 2004 Nature Publishing Group All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/geneen_HK
dc.relation.ispartofGenes and Immunityen_HK
dc.subjectHaplotypeen_HK
dc.subjectInterleukin 10en_HK
dc.subjectPolymorphismen_HK
dc.subjectSystemic lupus erythematosusen_HK
dc.subject.meshAdult-
dc.subject.meshInterleukin-10 - genetics-
dc.subject.meshLupus Erythematosus, Systemic - genetics-
dc.subject.meshPolymorphism, Single Nucleotide - genetics-
dc.subject.meshPromoter Regions, Genetic - genetics-
dc.titleAssociation of interleukin-10 promoter polymorphisms with systemic lupus erythematosusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1466-4879&volume=5&issue=6&spage=484&epage=492&date=2004&atitle=Association+of+interleukin-10+promoter+polymorphisms+with+systemic+lupus+erythematosusen_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.emailChan, TM:dtmchan@hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/sj.gene.6364119en_HK
dc.identifier.pmid15295621-
dc.identifier.scopuseid_2-s2.0-4644299001en_HK
dc.identifier.hkuros96428en_HK
dc.identifier.hkuros162909-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4644299001&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue6en_HK
dc.identifier.spage484en_HK
dc.identifier.epage492en_HK
dc.identifier.isiWOS:000223626500006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChong, WP=8634104400en_HK
dc.identifier.scopusauthoridIp, WK=35083568800en_HK
dc.identifier.scopusauthoridWong, WHS=35789454600en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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