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Article: Carotid intima-media thickness is increased and related to arterial stiffening in patients with beta-thalassaemia major

TitleCarotid intima-media thickness is increased and related to arterial stiffening in patients with beta-thalassaemia major
Authors
KeywordsArterial stiffness
Intima-media thickness
Thalassaemia
Issue Date2006
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 2006, v. 135 n. 5, p. 732-734 How to Cite?
AbstractAn increased iron store has been linked to the risk of atherosclerosis. The carotid intima-media thickness (IMT), stiffness index, Young's elastic modulus (YEM), and augmentation index were determined in 20 patients with beta-thalassaemia major. Compared with controls, patients had greater IMT (P < 0.001), YEM (P = 0.005), and stiffness (P = 0.009) and augmentation (P = 0.03) indices. The odds ratio for increased IMT in patients was 39. Carotid IMT correlated with YEM (P = 0.036), stiffness index (P = 0.036) and augmentation index (P = 0.006). Multivariate analysis identified patient status (P < 0.001) as the only significant determinant of IMT. These findings suggest the possibility of premature atherosclerosis in beta-thalassaemia major patients. © 2006 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/79843
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, YFen_HK
dc.contributor.authorChow, PCen_HK
dc.contributor.authorChan, GCen_HK
dc.contributor.authorHa, SYen_HK
dc.date.accessioned2010-09-06T07:59:23Z-
dc.date.available2010-09-06T07:59:23Z-
dc.date.issued2006en_HK
dc.identifier.citationBritish Journal Of Haematology, 2006, v. 135 n. 5, p. 732-734en_HK
dc.identifier.issn0007-1048en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79843-
dc.description.abstractAn increased iron store has been linked to the risk of atherosclerosis. The carotid intima-media thickness (IMT), stiffness index, Young's elastic modulus (YEM), and augmentation index were determined in 20 patients with beta-thalassaemia major. Compared with controls, patients had greater IMT (P < 0.001), YEM (P = 0.005), and stiffness (P = 0.009) and augmentation (P = 0.03) indices. The odds ratio for increased IMT in patients was 39. Carotid IMT correlated with YEM (P = 0.036), stiffness index (P = 0.036) and augmentation index (P = 0.006). Multivariate analysis identified patient status (P < 0.001) as the only significant determinant of IMT. These findings suggest the possibility of premature atherosclerosis in beta-thalassaemia major patients. © 2006 The Authors.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_HK
dc.relation.ispartofBritish Journal of Haematologyen_HK
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectArterial stiffnessen_HK
dc.subjectIntima-media thicknessen_HK
dc.subjectThalassaemiaen_HK
dc.titleCarotid intima-media thickness is increased and related to arterial stiffening in patients with beta-thalassaemia majoren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1048&volume=135&spage=732&epage=734&date=2006&atitle=Carotid+intima-media+thickness+is+increased+and+related+to+arterial+stiffening+in+patients+with+beta-thalassaemia+majoren_HK
dc.identifier.emailCheung, YF:xfcheung@hku.hken_HK
dc.identifier.emailChan, GC:gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityCheung, YF=rp00382en_HK
dc.identifier.authorityChan, GC=rp00431en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-2141.2006.06349.xen_HK
dc.identifier.pmid17107355-
dc.identifier.scopuseid_2-s2.0-33750550296en_HK
dc.identifier.hkuros125117en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750550296&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume135en_HK
dc.identifier.issue5en_HK
dc.identifier.spage732en_HK
dc.identifier.epage734en_HK
dc.identifier.isiWOS:000241733900016-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, YF=7202111067en_HK
dc.identifier.scopusauthoridChow, PC=23099233800en_HK
dc.identifier.scopusauthoridChan, GC=16160154400en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.citeulike928108-

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