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Article: Paediatric liver transplantation: Queen Mary Hospital experience

TitlePaediatric liver transplantation: Queen Mary Hospital experience
Authors
Issue Date1998
PublisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/
Citation
Chinese Medical Journal, 1998, v. 111 n. 7, p. 610-614 How to Cite?
AbstractObjective To assess the results of paediatric liver transplantation in our institution. Methods From September 1993 to November 1996, 10 living-related liver transplants (LRLT) and 3 reduced-size liver transplants (RSLT) were performed on 12 children at our hospital. The medical records of the patients were reviewed. All patients suffered from end-stage liver disease resulting from biliary atresia with failed Kasai's operations. Their ages at initial transplantation ranged from 8 months to 11 years. Excluding the 2 older children aged 7.5 and 11 years, the remaining patients were aged 10.5 months on the average and weighed 6 to 9.5 kg (mean: 6.8 kg) at the time of initial transplantation. Results All living donors were discharged on postoperative day 4 to 8 and resumed their previous normal activities. All recipients were alive with normal liver function and growing after a follow-up period of 3- 40 months (mean: 21 months). The patient survival rate was 100%. One patient with RSLT had hepatitis of undetermined aetiology and underwent retransplant with a graft from her mother. The graft survival rate was 92%. Postoperative complications included : post- operative bleeding (n = 3), hepatic vein stenosis (n = 1), biliary-enteric anastomotic stenosis (n = 3), intestinal perforation (n = 1) and portal vein thrombosis ( n = 1). They were all treated promptly. In all patients, the hepatic artery (diameter ranged from 1.5 to 2.5 mm) anastomosis was achieved by microvascular technique. There was no hepatic artery thrombosis in our patients. Conclusion With technical refinements, early detection and prompt treatment of complications, and advances in immunotherapy, excellent results can be achieved in paediatric liver transplantation.
Persistent Identifierhttp://hdl.handle.net/10722/79293
ISSN
2015 Impact Factor: 0.957
2015 SCImago Journal Rankings: 0.428
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KLen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorSaing, Hen_HK
dc.contributor.authorWei, WIen_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorTsoi, NSen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorChau, MTen_HK
dc.contributor.authorTsoi, WKen_HK
dc.contributor.authorChau, Jen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorTam, PKHen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T07:52:56Z-
dc.date.available2010-09-06T07:52:56Z-
dc.date.issued1998en_HK
dc.identifier.citationChinese Medical Journal, 1998, v. 111 n. 7, p. 610-614en_HK
dc.identifier.issn0366-6999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79293-
dc.description.abstractObjective To assess the results of paediatric liver transplantation in our institution. Methods From September 1993 to November 1996, 10 living-related liver transplants (LRLT) and 3 reduced-size liver transplants (RSLT) were performed on 12 children at our hospital. The medical records of the patients were reviewed. All patients suffered from end-stage liver disease resulting from biliary atresia with failed Kasai's operations. Their ages at initial transplantation ranged from 8 months to 11 years. Excluding the 2 older children aged 7.5 and 11 years, the remaining patients were aged 10.5 months on the average and weighed 6 to 9.5 kg (mean: 6.8 kg) at the time of initial transplantation. Results All living donors were discharged on postoperative day 4 to 8 and resumed their previous normal activities. All recipients were alive with normal liver function and growing after a follow-up period of 3- 40 months (mean: 21 months). The patient survival rate was 100%. One patient with RSLT had hepatitis of undetermined aetiology and underwent retransplant with a graft from her mother. The graft survival rate was 92%. Postoperative complications included : post- operative bleeding (n = 3), hepatic vein stenosis (n = 1), biliary-enteric anastomotic stenosis (n = 3), intestinal perforation (n = 1) and portal vein thrombosis ( n = 1). They were all treated promptly. In all patients, the hepatic artery (diameter ranged from 1.5 to 2.5 mm) anastomosis was achieved by microvascular technique. There was no hepatic artery thrombosis in our patients. Conclusion With technical refinements, early detection and prompt treatment of complications, and advances in immunotherapy, excellent results can be achieved in paediatric liver transplantation.en_HK
dc.languageengen_HK
dc.publisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/en_HK
dc.relation.ispartofChinese Medical Journalen_HK
dc.subject.meshBiliary Atresia - complications - surgeryen_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshCyclosporine - therapeutic useen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunosuppressive Agents - therapeutic useen_HK
dc.subject.meshInfanten_HK
dc.subject.meshLiver Diseases - etiology - surgeryen_HK
dc.subject.meshLiver Transplantation - methodsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshPortoenterostomy, Hepaticen_HK
dc.titlePaediatric liver transplantation: Queen Mary Hospital experienceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0366-6999&volume=111&spage=610&epage=614&date=1998&atitle=Paediatric+liver+transplantation:+Queen+Mary+Hospital+experienceen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.emailNg, IOL: iolng@hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid11245047en_HK
dc.identifier.scopuseid_2-s2.0-0000027765en_HK
dc.identifier.hkuros33079en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0000027765&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume111en_HK
dc.identifier.issue7en_HK
dc.identifier.spage610en_HK
dc.identifier.epage614en_HK
dc.identifier.isiWOS:000075201000009-
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridSaing, H=7005715754en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK
dc.identifier.scopusauthoridLo, CM=7401771672en_HK
dc.identifier.scopusauthoridTsoi, NS=6603693887en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridChau, MT=7006073758en_HK
dc.identifier.scopusauthoridTsoi, WK=7005719683en_HK
dc.identifier.scopusauthoridChau, J=36941254000en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK
dc.identifier.scopusauthoridChan, KL=37004089600en_HK

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