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Article: Cystatin C assay for the detection of renal dysfunction in Chinese renal transplant recipients

TitleCystatin C assay for the detection of renal dysfunction in Chinese renal transplant recipients
Authors
KeywordsCreatinine clearance
Cystatin C
Glomerular filtration rate
Receiver operating characteristic
Renal transplantation
Serum creatinine
Issue Date2002
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/cca
Citation
Clinica Chimica Acta, 2002, v. 322 n. 1-2, p. 133-137 How to Cite?
AbstractBackground: Accurate and rapid assessment of kidney function in patients after renal transplantation is of major significance. We investigated whether cystatin C can accurately reflect creatinine clearance over the entire range of kidney graft function. The performance of serum cystatin C as a screening marker of reduced creatinine clearance in renal transplantation was evaluated and compared to serum creatinine. Methods: Serum cystatin C, serum creatinine and creatinine clearance were measured in 103 adult renal transplant recipients. The cystatin C assay was performed using particle-enhanced immunonephelometry. Results: We demonstrated a significant linear correlation between 1/cystatin C and creatinine clearance over the entire range of transplant function, comparable to that of creatinine. Cystatin C detected reduced creatinine clearance with higher sensitivity of 92.9% (95% CI 80.5-98.4%) than serum creatinine, 71.4% (95% CI 55.4-84.3%). From the receiver operating characteristic (ROC) plots, serum cystatin C is superior to serum creatinine at 90% and 95% sensitivity. Conclusions: Serum cystatin C accurately reflects creatinine clearance over the entire range of transplant kidney function and is more efficacious than serum creatinine to detect reduced creatinine clearance in renal transplant recipients. © 2002 Elsevier Science B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/78737
ISSN
2015 Impact Factor: 2.799
2015 SCImago Journal Rankings: 1.040
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, FKen_HK
dc.contributor.authorHo, SKNen_HK
dc.contributor.authorYip, TPSen_HK
dc.contributor.authorTse, KCen_HK
dc.contributor.authorChan, TMen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2010-09-06T07:46:10Z-
dc.date.available2010-09-06T07:46:10Z-
dc.date.issued2002en_HK
dc.identifier.citationClinica Chimica Acta, 2002, v. 322 n. 1-2, p. 133-137en_HK
dc.identifier.issn0009-8981en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78737-
dc.description.abstractBackground: Accurate and rapid assessment of kidney function in patients after renal transplantation is of major significance. We investigated whether cystatin C can accurately reflect creatinine clearance over the entire range of kidney graft function. The performance of serum cystatin C as a screening marker of reduced creatinine clearance in renal transplantation was evaluated and compared to serum creatinine. Methods: Serum cystatin C, serum creatinine and creatinine clearance were measured in 103 adult renal transplant recipients. The cystatin C assay was performed using particle-enhanced immunonephelometry. Results: We demonstrated a significant linear correlation between 1/cystatin C and creatinine clearance over the entire range of transplant function, comparable to that of creatinine. Cystatin C detected reduced creatinine clearance with higher sensitivity of 92.9% (95% CI 80.5-98.4%) than serum creatinine, 71.4% (95% CI 55.4-84.3%). From the receiver operating characteristic (ROC) plots, serum cystatin C is superior to serum creatinine at 90% and 95% sensitivity. Conclusions: Serum cystatin C accurately reflects creatinine clearance over the entire range of transplant kidney function and is more efficacious than serum creatinine to detect reduced creatinine clearance in renal transplant recipients. © 2002 Elsevier Science B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ccaen_HK
dc.relation.ispartofClinica Chimica Actaen_HK
dc.rightsClinica Chimica Acta. Copyright © Elsevier BV.en_HK
dc.subjectCreatinine clearanceen_HK
dc.subjectCystatin Cen_HK
dc.subjectGlomerular filtration rateen_HK
dc.subjectReceiver operating characteristicen_HK
dc.subjectRenal transplantationen_HK
dc.subjectSerum creatinineen_HK
dc.subject.meshAdulten_HK
dc.subject.meshChinaen_HK
dc.subject.meshCreatinine - blooden_HK
dc.subject.meshCystatin Cen_HK
dc.subject.meshCystatins - blooden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKidney - physiopathologyen_HK
dc.subject.meshKidney Transplantationen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshRenal Insufficiency - blood - diagnosisen_HK
dc.subject.meshSensitivity and Specificityen_HK
dc.titleCystatin C assay for the detection of renal dysfunction in Chinese renal transplant recipientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0009-8981&volume=322&spage=133&epage=137&date=2002&atitle=Cystatin+C+Assay+for+the+Detection+of+Renal+Dysfunction+in+Chinese+Renal+Transplant+Recipientsen_HK
dc.identifier.emailChan, TM: dtmchan@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0009-8981(02)00159-6en_HK
dc.identifier.pmid12104092-
dc.identifier.scopuseid_2-s2.0-0036294251en_HK
dc.identifier.hkuros81776en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036294251&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume322en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage133en_HK
dc.identifier.epage137en_HK
dc.identifier.isiWOS:000177348800018-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLi, FK=8219093900en_HK
dc.identifier.scopusauthoridHo, SKN=36839065300en_HK
dc.identifier.scopusauthoridYip, TPS=7004283977en_HK
dc.identifier.scopusauthoridTse, KC=7102609864en_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK

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