File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Serum adipocyte fatty acid-binding protein as a new biomarker predicting the development of type 2 diabetes: A 10-year prospective study in a Chinese cohort

TitleSerum adipocyte fatty acid-binding protein as a new biomarker predicting the development of type 2 diabetes: A 10-year prospective study in a Chinese cohort
Authors
Issue Date2007
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
Citation
Diabetes Care, 2007, v. 30 n. 10, p. 2667-2672 How to Cite?
AbstractOBJECTIVE - Adipocyte fatty acid-binding protein (A-FABP) is abundantly expressed in adipocytes and plays a role in glucose homeostasis in experimental animals. We have previously shown that circulating A-FABP levels are associated with the metabolic syndrome, which confers an increased risk of type 2 diabetes. Here we investigated whether serum A-FABP levels could predict the development of diabetes in a 10-year prospective study. RESEARCH DESIGN AND METHODS - Baseline serum A-FABP levels were measured with an enzyme-linked immunosorbent assay in 544 nondiabetic subjects, recruited from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort, who were followed prospectively to assess the development of type 2 diabetes. The role of A-FABP in predicting the development of type 2 diabetes over 10 years was investigated using Cox regression analysis. RESULTS - At baseline, serum sex-adjusted A-FABP levels were higher in subjects with impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) (P < 0.00001 versus normal glucose tolerance) and correlated positively with adverse cardiometabolic risk factors. Over 10 years, 96 subjects had developed type 2 diabetes. High baseline A-FABP was predictive of type 2 diabetes, independent of obesity, insulin resistance, or glycemic indexes (relative risk [RR] 2.25 [95% CI 1.40 -3.65]; P = 0.001; above versus below sex-specific median). High A-FABP levels remained an independent predictor of type 2 diabetes in the high-risk IGT/IFG subgroup (adjusted RR 1.87 [1.12-3.15]; P = 0.018). CONCLUSIONS - Serum A-FABP was associated with glucose dysregulation and predicted the development of type 2 diabetes in a Chinese cohort. © 2007 by the American Diabetes Association.
Persistent Identifierhttp://hdl.handle.net/10722/78612
ISSN
2015 Impact Factor: 8.934
2015 SCImago Journal Rankings: 5.827
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorFong, CHYen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorJanus, EDen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-09-06T07:44:48Z-
dc.date.available2010-09-06T07:44:48Z-
dc.date.issued2007en_HK
dc.identifier.citationDiabetes Care, 2007, v. 30 n. 10, p. 2667-2672en_HK
dc.identifier.issn0149-5992en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78612-
dc.description.abstractOBJECTIVE - Adipocyte fatty acid-binding protein (A-FABP) is abundantly expressed in adipocytes and plays a role in glucose homeostasis in experimental animals. We have previously shown that circulating A-FABP levels are associated with the metabolic syndrome, which confers an increased risk of type 2 diabetes. Here we investigated whether serum A-FABP levels could predict the development of diabetes in a 10-year prospective study. RESEARCH DESIGN AND METHODS - Baseline serum A-FABP levels were measured with an enzyme-linked immunosorbent assay in 544 nondiabetic subjects, recruited from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort, who were followed prospectively to assess the development of type 2 diabetes. The role of A-FABP in predicting the development of type 2 diabetes over 10 years was investigated using Cox regression analysis. RESULTS - At baseline, serum sex-adjusted A-FABP levels were higher in subjects with impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) (P < 0.00001 versus normal glucose tolerance) and correlated positively with adverse cardiometabolic risk factors. Over 10 years, 96 subjects had developed type 2 diabetes. High baseline A-FABP was predictive of type 2 diabetes, independent of obesity, insulin resistance, or glycemic indexes (relative risk [RR] 2.25 [95% CI 1.40 -3.65]; P = 0.001; above versus below sex-specific median). High A-FABP levels remained an independent predictor of type 2 diabetes in the high-risk IGT/IFG subgroup (adjusted RR 1.87 [1.12-3.15]; P = 0.018). CONCLUSIONS - Serum A-FABP was associated with glucose dysregulation and predicted the development of type 2 diabetes in a Chinese cohort. © 2007 by the American Diabetes Association.en_HK
dc.languageengen_HK
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/en_HK
dc.relation.ispartofDiabetes Careen_HK
dc.titleSerum adipocyte fatty acid-binding protein as a new biomarker predicting the development of type 2 diabetes: A 10-year prospective study in a Chinese cohorten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0149-5992&volume=30&spage=2667&epage=72&date=2007&atitle=Serum+adipocyte+fatty+acid+binding+protein+as+a+new+biomarker+predicting+the+development+of+type+2+diabetes:+a+10-year+prospective+study+in+a+Chinese+cohorten_HK
dc.identifier.emailTso, AWK: awk.tso@gmail.comen_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailWang, Y: yuwanghk@hku.hken_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityTso, AWK=rp00535en_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityWang, Y=rp00239en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2337/dc07-0413en_HK
dc.identifier.pmid17620449-
dc.identifier.scopuseid_2-s2.0-35148875083en_HK
dc.identifier.hkuros140657en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35148875083&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue10en_HK
dc.identifier.spage2667en_HK
dc.identifier.epage2672en_HK
dc.identifier.eissn1935-5548-
dc.identifier.isiWOS:000250223400052-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTso, AWK=6701371436en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridWat, NMS=6602131754en_HK
dc.identifier.scopusauthoridWang, Y=34973733700en_HK
dc.identifier.scopusauthoridFong, CHY=14033917100en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats