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Article: Recurrent glomerulonephritis after kidney transplantation

TitleRecurrent glomerulonephritis after kidney transplantation
Authors
KeywordsGlomerulonephritis
Recurrence
Renal transplant
Treatment
Issue Date2006
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AJT
Citation
American Journal Of Transplantation, 2006, v. 6 n. 11, p. 2535-2542 How to Cite?
AbstractThirty to fifty percent of kidney transplant recipients have glomerular diseases as the underlying causes of end-stage renal failure. While recurrence of glomerulonephritis is an important cause of late renal allograft failure, the risk factors for recurrence are largely unknown or imprecise and prediction remains difficult. Recurrent disease usually presents with similar manifestations as the native disease. With regard to treatment of recurrent glomerular disease in the renal allograft, plasma exchange may be effective in reducing proteinuria in patients with early recurrence of focal and segmental glomerulosclerosis, but immunosuppressive therapy is generally ineffective in the prevention or treatment of recurrent disease. General supportive measures including strict blood pressure control and inhibition or blockade of the rennin-angiotensin pathway are helpful in retarding the rate of deterioration in renal allograft function. Despite the risk of recurrence, kidney transplantation following primary glomerulonephritides enjoys graft and patient survival rates comparable to other causes of end-stage renal failure. With a few exceptions, living related renal transplantation is not contraindicated in view of the favorable outcome and the donor shortage. This review discusses commonly encountered recurrent glomerulonephritides, with special emphasis on the influence of post-transplant prophylactic immunosuppression and emerging treatments. © 2006 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/78608
ISSN
2015 Impact Factor: 5.669
2015 SCImago Journal Rankings: 2.792
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChoy, BYen_HK
dc.contributor.authorChan, TMen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2010-09-06T07:44:46Z-
dc.date.available2010-09-06T07:44:46Z-
dc.date.issued2006en_HK
dc.identifier.citationAmerican Journal Of Transplantation, 2006, v. 6 n. 11, p. 2535-2542en_HK
dc.identifier.issn1600-6135en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78608-
dc.description.abstractThirty to fifty percent of kidney transplant recipients have glomerular diseases as the underlying causes of end-stage renal failure. While recurrence of glomerulonephritis is an important cause of late renal allograft failure, the risk factors for recurrence are largely unknown or imprecise and prediction remains difficult. Recurrent disease usually presents with similar manifestations as the native disease. With regard to treatment of recurrent glomerular disease in the renal allograft, plasma exchange may be effective in reducing proteinuria in patients with early recurrence of focal and segmental glomerulosclerosis, but immunosuppressive therapy is generally ineffective in the prevention or treatment of recurrent disease. General supportive measures including strict blood pressure control and inhibition or blockade of the rennin-angiotensin pathway are helpful in retarding the rate of deterioration in renal allograft function. Despite the risk of recurrence, kidney transplantation following primary glomerulonephritides enjoys graft and patient survival rates comparable to other causes of end-stage renal failure. With a few exceptions, living related renal transplantation is not contraindicated in view of the favorable outcome and the donor shortage. This review discusses commonly encountered recurrent glomerulonephritides, with special emphasis on the influence of post-transplant prophylactic immunosuppression and emerging treatments. © 2006 The Authors.en_HK
dc.languageengen_HK
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AJTen_HK
dc.relation.ispartofAmerican Journal of Transplantationen_HK
dc.subjectGlomerulonephritisen_HK
dc.subjectRecurrenceen_HK
dc.subjectRenal transplanten_HK
dc.subjectTreatmenten_HK
dc.subject.meshDiabetic Nephropathies - surgeryen_HK
dc.subject.meshGlomerulonephritis - classification - epidemiology - surgeryen_HK
dc.subject.meshGlomerulonephritis, IGA - surgeryen_HK
dc.subject.meshGlomerulonephritis, Membranoproliferative - surgeryen_HK
dc.subject.meshGlomerulonephritis, Membranous - surgeryen_HK
dc.subject.meshGlomerulosclerosis, Focal Segmental - surgeryen_HK
dc.subject.meshKidney Transplantation - adverse effectsen_HK
dc.subject.meshLupus Erythematosus, Systemic - surgeryen_HK
dc.subject.meshPostoperative Complications - epidemiologyen_HK
dc.subject.meshRecurrenceen_HK
dc.titleRecurrent glomerulonephritis after kidney transplantationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1600-6135&volume=6&spage=2535&epage=2542&date=2006&atitle=Recurrent+glomerulonephritis+after+kidney+transplantationen_HK
dc.identifier.emailChan, TM: dtmchan@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-6143.2006.01502.xen_HK
dc.identifier.pmid16939521-
dc.identifier.scopuseid_2-s2.0-33750005603en_HK
dc.identifier.hkuros132110en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750005603&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue11en_HK
dc.identifier.spage2535en_HK
dc.identifier.epage2542en_HK
dc.identifier.isiWOS:000241240700005-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridChoy, BY=7003465499en_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.citeulike899947-

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