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Article: Nephrotoxicity of immunosuppressive agents in renal transplantation

TitleNephrotoxicity of immunosuppressive agents in renal transplantation
Authors
KeywordsCyclosporine/therapeutic use
Immunosuppression
Survival rate
Transforming growth factor-beta/metabolism
Issue Date2002
PublisherLippincott Williams & Wilkins Asia. The Journal's web site is located at http://www.hkjn.org/
Citation
Hong Kong Journal Of Nephrology, 2002, v. 4 n. 2, p. 65-72 How to Cite?
AbstractThe outcome of solid organ transplantation has improved significantly in the past few decades with the advent of cyclosporine and other newer immunosuppressive agents including tacrolimus, mycophenolate mofetil, interleukin-2 receptor blockers, and rapamycin. A prominent consequence of the development in posttransplant immunosuppressive regimens is the reduced incidence of acute rejections, from 30% to 40% to approximately 15% or even lower (Gjertson, Clin Transpl 2000:467-80), although it still remains an important risk factor compromising long-term renal allograft survival. The acute and chronic nephrotoxicity of immunosuppressive agents, notably calcineurin inhibitors, have attracted increasing attention, and the reduction of these untoward effects has constituted an important theme of clinical research in transplantation. The current knowledge on the spectrum and mechanisms of nephrotoxicity pertinent to immunosuppressive agents used in renal transplantation is reviewed in this article and possible strategies for prevention or amelioration of the nephrotoxicity; the future directions for investigations are also discussed.
Persistent Identifierhttp://hdl.handle.net/10722/78588
ISSN
2015 SCImago Journal Rankings: 0.166
References

 

DC FieldValueLanguage
dc.contributor.authorTse, KCen_HK
dc.contributor.authorChan, TMen_HK
dc.date.accessioned2010-09-06T07:44:32Z-
dc.date.available2010-09-06T07:44:32Z-
dc.date.issued2002en_HK
dc.identifier.citationHong Kong Journal Of Nephrology, 2002, v. 4 n. 2, p. 65-72en_HK
dc.identifier.issn1561-5413en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78588-
dc.description.abstractThe outcome of solid organ transplantation has improved significantly in the past few decades with the advent of cyclosporine and other newer immunosuppressive agents including tacrolimus, mycophenolate mofetil, interleukin-2 receptor blockers, and rapamycin. A prominent consequence of the development in posttransplant immunosuppressive regimens is the reduced incidence of acute rejections, from 30% to 40% to approximately 15% or even lower (Gjertson, Clin Transpl 2000:467-80), although it still remains an important risk factor compromising long-term renal allograft survival. The acute and chronic nephrotoxicity of immunosuppressive agents, notably calcineurin inhibitors, have attracted increasing attention, and the reduction of these untoward effects has constituted an important theme of clinical research in transplantation. The current knowledge on the spectrum and mechanisms of nephrotoxicity pertinent to immunosuppressive agents used in renal transplantation is reviewed in this article and possible strategies for prevention or amelioration of the nephrotoxicity; the future directions for investigations are also discussed.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins Asia. The Journal's web site is located at http://www.hkjn.org/en_HK
dc.relation.ispartofHong Kong Journal of Nephrologyen_HK
dc.subjectCyclosporine/therapeutic useen_HK
dc.subjectImmunosuppressionen_HK
dc.subjectSurvival rateen_HK
dc.subjectTransforming growth factor-beta/metabolismen_HK
dc.titleNephrotoxicity of immunosuppressive agents in renal transplantationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1561-5413&volume=4&issue=2&spage=65&epage=72&date=2002&atitle=Nephrotoxicity+of+immunosuppressive+agents+in+renal+transplantationen_HK
dc.identifier.emailChan, TM:dtmchan@hku.hken_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-0036919702en_HK
dc.identifier.hkuros79050en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036919702&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume4en_HK
dc.identifier.issue2en_HK
dc.identifier.spage65en_HK
dc.identifier.epage72en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridTse, KC=7102609864en_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK

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