File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Epidemiologic and virologic characteristics of hepatitis B virus genotype B having the recombination with genotype C

TitleEpidemiologic and virologic characteristics of hepatitis B virus genotype B having the recombination with genotype C
Authors
Issue Date2003
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
Gastroenterology, 2003, v. 124 n. 4, p. 925-932 How to Cite?
AbstractBackground & Aims: Hepatitis B virus (HBV) isolates of genotype B (HBV/B) with or without the recombination with genotype C over the precore region plus core gene have been reported. Methods: All the 41 HBV/B isolates having the recombination with genotype C (HBV/Ba) possessed the nucleotide 1838 of A in contrast to that of G in all 29 of those without the recombination (HBV/ Bj). Taking advantage of this single nucleotide polymorphism, a restriction fragment length polymorphism method was developed that distinguished HBV/Ba from HBV/Bj. Results: HBV/Bj was detected in 90 of the 97 (93%) carriers of HBV/B from Japan, whereas HBV/Ba occurred in all 177 carriers of HBV/B from other countries (China, 20; Hong Kong, 45; Taiwan, 32; Thailand, 30; Vietnam, 30; and the United States, 20 [all of an Asian ethnicity]). In a case-control study, hepatitis B e antigen (HBeAg) and the double mutation in the core promoter (T1762/A1764) were significantly more frequent in 80 carriers each of HBV/Ba than HBV/Bj (35% vs. 18%, P < 0.05 and 33% vs. 15%, P < 0.05, respectively). Differences in the prevalence of HBeAg were more conspicuous between the carriers of HBV/Bj and HBV/Ba older than 30 years (5 of 66 or 8% vs. 16 of 62 or 26%, P < 0.01). Conclusions: HBV/B having the recombination with genotype C is frequent in Asia, except in Japan, and HBeAg is more prevalent in carriers of HBV/Ba than HBV/Bj.
Persistent Identifierhttp://hdl.handle.net/10722/78540
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSugauchi, Fen_HK
dc.contributor.authorOrito, Een_HK
dc.contributor.authorIchida, Ten_HK
dc.contributor.authorKato, Hen_HK
dc.contributor.authorSakugawa, Hen_HK
dc.contributor.authorKakumu, Sen_HK
dc.contributor.authorIshida, Ten_HK
dc.contributor.authorChutaputti, Aen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorGish, RGen_HK
dc.contributor.authorUeda, Ren_HK
dc.contributor.authorMiyakawa, Yen_HK
dc.contributor.authorMizokami, Men_HK
dc.date.accessioned2010-09-06T07:44:00Z-
dc.date.available2010-09-06T07:44:00Z-
dc.date.issued2003en_HK
dc.identifier.citationGastroenterology, 2003, v. 124 n. 4, p. 925-932en_HK
dc.identifier.issn0016-5085en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78540-
dc.description.abstractBackground & Aims: Hepatitis B virus (HBV) isolates of genotype B (HBV/B) with or without the recombination with genotype C over the precore region plus core gene have been reported. Methods: All the 41 HBV/B isolates having the recombination with genotype C (HBV/Ba) possessed the nucleotide 1838 of A in contrast to that of G in all 29 of those without the recombination (HBV/ Bj). Taking advantage of this single nucleotide polymorphism, a restriction fragment length polymorphism method was developed that distinguished HBV/Ba from HBV/Bj. Results: HBV/Bj was detected in 90 of the 97 (93%) carriers of HBV/B from Japan, whereas HBV/Ba occurred in all 177 carriers of HBV/B from other countries (China, 20; Hong Kong, 45; Taiwan, 32; Thailand, 30; Vietnam, 30; and the United States, 20 [all of an Asian ethnicity]). In a case-control study, hepatitis B e antigen (HBeAg) and the double mutation in the core promoter (T1762/A1764) were significantly more frequent in 80 carriers each of HBV/Ba than HBV/Bj (35% vs. 18%, P < 0.05 and 33% vs. 15%, P < 0.05, respectively). Differences in the prevalence of HBeAg were more conspicuous between the carriers of HBV/Bj and HBV/Ba older than 30 years (5 of 66 or 8% vs. 16 of 62 or 26%, P < 0.01). Conclusions: HBV/B having the recombination with genotype C is frequent in Asia, except in Japan, and HBeAg is more prevalent in carriers of HBV/Ba than HBV/Bj.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastroen_HK
dc.relation.ispartofGastroenterologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAsia - epidemiologyen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshHepatitis B - epidemiology - virologyen_HK
dc.subject.meshHepatitis B e Antigens - geneticsen_HK
dc.subject.meshHepatitis B virus - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshPromoter Regions, Genetic - geneticsen_HK
dc.subject.meshRecombination, Geneticen_HK
dc.titleEpidemiologic and virologic characteristics of hepatitis B virus genotype B having the recombination with genotype Cen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0016-5085&volume=124&spage=925&epage=932&date=2003&atitle=Epidemiologic+and+Virologic+Characteristics+of+Hepatitis+B+Virus+Genotype+B+having+the+Recombination+with+Genotype+Cen_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1053/gast.2003.50140en_HK
dc.identifier.pmid12671889-
dc.identifier.scopuseid_2-s2.0-0037382062en_HK
dc.identifier.hkuros80553en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037382062&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume124en_HK
dc.identifier.issue4en_HK
dc.identifier.spage925en_HK
dc.identifier.epage932en_HK
dc.identifier.isiWOS:000182002700013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSugauchi, F=7004837927en_HK
dc.identifier.scopusauthoridOrito, E=7006161634en_HK
dc.identifier.scopusauthoridIchida, T=7102582635en_HK
dc.identifier.scopusauthoridKato, H=7406496874en_HK
dc.identifier.scopusauthoridSakugawa, H=7006875192en_HK
dc.identifier.scopusauthoridKakumu, S=7007147262en_HK
dc.identifier.scopusauthoridIshida, T=35353530100en_HK
dc.identifier.scopusauthoridChutaputti, A=6603176195en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridGish, RG=7007037133en_HK
dc.identifier.scopusauthoridUeda, R=35376281000en_HK
dc.identifier.scopusauthoridMiyakawa, Y=7102670114en_HK
dc.identifier.scopusauthoridMizokami, M=7103318255en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats