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Article: Disseminated Ochroconis gallopavum infection in a renal transplant recipient: The first reported case and a review of the literature

TitleDisseminated Ochroconis gallopavum infection in a renal transplant recipient: The first reported case and a review of the literature
Authors
KeywordsAntifungal agents
Dematiaceous fungi
Disseminated Ochroconis gallopavum
Renal transplant recipient
Issue Date2003
PublisherDustri-Verlag Dr. Karl Feistle. The Journal's web site is located at http://www.clinnephrol.com
Citation
Clinical Nephrology, 2003, v. 60 n. 6, p. 415-423 How to Cite?
AbstractOchroconis gallopavum is a potentially fatal dematiaceous fungus causing opportunistic infections in immunocompromised hosts. We report the first case of disseminated O. gallopavum infection in a 13-year-old renal transplant recipient, which involved the brain, lung and spleen. He was treated with amphotericin B, itraconazole and voriconazole, a new antifungal agent first used to treat such an infection. Besides antifungal treatment, all immunosuppressive agents were stopped and automated peritoneal dialysis was resumed. The initial infection was under control with both clinical and radiological improvements after treatment. However, the patient later acquired Acremonium spp. peritonitis; he failed to respond to high-dose amphotericin B, and finally succumbed. A total of 13 reported O. gallopavum human infections, including the one described here, are reviewed. The most common site of involvement is the brain and the crude mortality rate is up to 46%. As the disease is potentially lethal in immunocompromised hosts, empirical antifungal coverage should be considered in post-renal transplant recipients with suspected brain abscess. Early biopsy of lesion for histopathological and microbiological diagnosis would be essential in managing such cases.
Persistent Identifierhttp://hdl.handle.net/10722/78519
ISSN
2015 Impact Factor: 1.065
2015 SCImago Journal Rankings: 0.498
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, TKFen_HK
dc.contributor.authorChiu, Wen_HK
dc.contributor.authorChim, Sen_HK
dc.contributor.authorChan, TMen_HK
dc.contributor.authorWong, SSYen_HK
dc.contributor.authorHo, PLen_HK
dc.date.accessioned2010-09-06T07:43:47Z-
dc.date.available2010-09-06T07:43:47Z-
dc.date.issued2003en_HK
dc.identifier.citationClinical Nephrology, 2003, v. 60 n. 6, p. 415-423en_HK
dc.identifier.issn0301-0430en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78519-
dc.description.abstractOchroconis gallopavum is a potentially fatal dematiaceous fungus causing opportunistic infections in immunocompromised hosts. We report the first case of disseminated O. gallopavum infection in a 13-year-old renal transplant recipient, which involved the brain, lung and spleen. He was treated with amphotericin B, itraconazole and voriconazole, a new antifungal agent first used to treat such an infection. Besides antifungal treatment, all immunosuppressive agents were stopped and automated peritoneal dialysis was resumed. The initial infection was under control with both clinical and radiological improvements after treatment. However, the patient later acquired Acremonium spp. peritonitis; he failed to respond to high-dose amphotericin B, and finally succumbed. A total of 13 reported O. gallopavum human infections, including the one described here, are reviewed. The most common site of involvement is the brain and the crude mortality rate is up to 46%. As the disease is potentially lethal in immunocompromised hosts, empirical antifungal coverage should be considered in post-renal transplant recipients with suspected brain abscess. Early biopsy of lesion for histopathological and microbiological diagnosis would be essential in managing such cases.en_HK
dc.languageengen_HK
dc.publisherDustri-Verlag Dr. Karl Feistle. The Journal's web site is located at http://www.clinnephrol.comen_HK
dc.relation.ispartofClinical Nephrologyen_HK
dc.subjectAntifungal agentsen_HK
dc.subjectDematiaceous fungien_HK
dc.subjectDisseminated Ochroconis gallopavumen_HK
dc.subjectRenal transplant recipienten_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAntifungal Agents - therapeutic useen_HK
dc.subject.meshBrain - microbiologyen_HK
dc.subject.meshFatal Outcomeen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunocompromised Hosten_HK
dc.subject.meshKidney Transplantationen_HK
dc.subject.meshLung - microbiologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMitosporic Fungien_HK
dc.subject.meshMycoses - diagnosis - drug therapyen_HK
dc.subject.meshOpportunistic Infections - diagnosis - drug therapyen_HK
dc.subject.meshPeritoneal Dialysisen_HK
dc.subject.meshSpleen - microbiologyen_HK
dc.titleDisseminated Ochroconis gallopavum infection in a renal transplant recipient: The first reported case and a review of the literatureen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0301-0430&volume=2003; 60&issue=6&spage=415&epage=23&date=2003&atitle=Disseminated+ochroconis+gallopavum+infection+in+a+renal+transplant+recipient:+the+first+reported+case+and+a+review+of+the+literatureen_HK
dc.identifier.emailChan, TM:dtmchan@hku.hken_HK
dc.identifier.emailWong, SSY:samsonsy@hkucc.hku.hken_HK
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.identifier.authorityWong, SSY=rp00395en_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid14690259-
dc.identifier.scopuseid_2-s2.0-1042303602en_HK
dc.identifier.hkuros87324en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1042303602&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume60en_HK
dc.identifier.issue6en_HK
dc.identifier.spage415en_HK
dc.identifier.epage423en_HK
dc.identifier.isiWOS:000187021800007-
dc.publisher.placeMünchen-Deisenhofen, Germanyen_HK
dc.identifier.scopusauthoridWang, TKF=7405566621en_HK
dc.identifier.scopusauthoridChiu, W=7201503406en_HK
dc.identifier.scopusauthoridChim, S=6701728225en_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK
dc.identifier.scopusauthoridWong, SSY=13310021400en_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK

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