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Article: Serological markers of liver cancer

TitleSerological markers of liver cancer
Authors
Issue Date2005
PublisherBailliere Tindall. The Journal's web site is located at http://www.elsevier.com/locate/bpg
Citation
Best Practice And Research: Clinical Gastroenterology, 2005, v. 19 n. 1 SPEC. ISS., p. 91-99 How to Cite?
AbstractSerological markers for hepatocellular carcinoma (HCC) are important for early diagnosis, as well as monitoring of tumour aggressiveness, treatment responsiveness, recurrence and survival. The three most common markers are total alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive AFP (AFP-L3) and protein induced by vitamin K absence or antagonist-II (PIVKA-II). Total AFP has the sensitivity of 60% and specificity of 90% for the detection of HCC. Increase in the percentage of AFP-L3 over the total AFP (>10%) is very specific for small HCC. PIVKA-II is also more specific than total AFP in detecting HCC. AFP-L3 and PIVKA-II levels correlate with tumour aggressiveness and prognosis. All three markers are useful for monitoring treatment responsiveness and tumour recurrence. Since the levels of the three markers are independent of each other, combination of measurement of two or three markers will increase the sensitivity and diagnostic accuracy. Some novel markers including glypican-3 are being extensively studied. © 2004 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/78512
ISSN
2015 Impact Factor: 3.897
2015 SCImago Journal Rankings: 1.406
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorLai, CLen_HK
dc.date.accessioned2010-09-06T07:43:42Z-
dc.date.available2010-09-06T07:43:42Z-
dc.date.issued2005en_HK
dc.identifier.citationBest Practice And Research: Clinical Gastroenterology, 2005, v. 19 n. 1 SPEC. ISS., p. 91-99en_HK
dc.identifier.issn1521-6918en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78512-
dc.description.abstractSerological markers for hepatocellular carcinoma (HCC) are important for early diagnosis, as well as monitoring of tumour aggressiveness, treatment responsiveness, recurrence and survival. The three most common markers are total alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive AFP (AFP-L3) and protein induced by vitamin K absence or antagonist-II (PIVKA-II). Total AFP has the sensitivity of 60% and specificity of 90% for the detection of HCC. Increase in the percentage of AFP-L3 over the total AFP (>10%) is very specific for small HCC. PIVKA-II is also more specific than total AFP in detecting HCC. AFP-L3 and PIVKA-II levels correlate with tumour aggressiveness and prognosis. All three markers are useful for monitoring treatment responsiveness and tumour recurrence. Since the levels of the three markers are independent of each other, combination of measurement of two or three markers will increase the sensitivity and diagnostic accuracy. Some novel markers including glypican-3 are being extensively studied. © 2004 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherBailliere Tindall. The Journal's web site is located at http://www.elsevier.com/locate/bpgen_HK
dc.relation.ispartofBest Practice and Research: Clinical Gastroenterologyen_HK
dc.subject.meshBiological Markers - blooden_HK
dc.subject.meshGlypicansen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Neoplasms - diagnosisen_HK
dc.subject.meshMembrane Proteins - blooden_HK
dc.subject.meshNeoplasm Proteins - blooden_HK
dc.subject.meshPlant Lectinsen_HK
dc.subject.meshProtein Precursors - blooden_HK
dc.subject.meshProthrombinen_HK
dc.subject.meshSensitivity and Specificityen_HK
dc.subject.meshSerologic Testsen_HK
dc.subject.meshTumor Markers, Biological - blooden_HK
dc.subject.meshalpha-Fetoproteins - analysisen_HK
dc.titleSerological markers of liver canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1521-6918&volume=19&issue=1&spage=91&epage=9&date=2005&atitle=Serological+markers+of+liver+cancer.en_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bpg.2004.10.003en_HK
dc.identifier.pmid15757806-
dc.identifier.scopuseid_2-s2.0-14744286203en_HK
dc.identifier.hkuros101370en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-14744286203&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue1 SPEC. ISS.en_HK
dc.identifier.spage91en_HK
dc.identifier.epage99en_HK
dc.identifier.isiWOS:000227994200006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK

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