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- Publisher Website: 10.1517/14656566.7.16.2225
- Scopus: eid_2-s2.0-39049185674
- PMID: 17059379
- WOS: WOS:000241643900004
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Article: Recommendations and potential future options in the treatment of hepatitis B
Title | Recommendations and potential future options in the treatment of hepatitis B |
---|---|
Authors | |
Keywords | Alanine aminotransferase Chronic hepatitis B HBeAg seroconversion HBV DNA Hepatitis B virus Interferon Nucleoside analogue Nucleotide analogue |
Issue Date | 2006 |
Publisher | Informa Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/eop |
Citation | Expert Opinion On Pharmacotherapy, 2006, v. 7 n. 16, p. 2225-2231 How to Cite? |
Abstract | The natural history of chronic hepatitis B should be clearly defined before appropriate recommendations for treatment can be advocated. In patients who acquire the disease in early life, the complications of chronic hepatitis B continue to occur as a result of prolonged insidious damage to the liver, even in the low viraemic phase. Treatment that ends with hepatitis B e antigen seroconversion with hepatitis B virus DNA levels just below 105 copies/ml may not be sufficient. Patients with mild elevation of alanine aminotransferase levels are already at considerable risk of developing complications. Treatment strategy should aim at maximal and prolonged viral suppression to the lowest possible hepatitis B virus DNA levels. Nucleotide/nucleoside analogues will become the mainstay of treatment. Future treatment strategic plans should target maximising antiviral potency and minimising the chance of drug resistance. © 2006 Informa UK Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/78468 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.687 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yuen, MF | en_HK |
dc.contributor.author | Lai, CL | en_HK |
dc.date.accessioned | 2010-09-06T07:43:13Z | - |
dc.date.available | 2010-09-06T07:43:13Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | Expert Opinion On Pharmacotherapy, 2006, v. 7 n. 16, p. 2225-2231 | en_HK |
dc.identifier.issn | 1465-6566 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/78468 | - |
dc.description.abstract | The natural history of chronic hepatitis B should be clearly defined before appropriate recommendations for treatment can be advocated. In patients who acquire the disease in early life, the complications of chronic hepatitis B continue to occur as a result of prolonged insidious damage to the liver, even in the low viraemic phase. Treatment that ends with hepatitis B e antigen seroconversion with hepatitis B virus DNA levels just below 105 copies/ml may not be sufficient. Patients with mild elevation of alanine aminotransferase levels are already at considerable risk of developing complications. Treatment strategy should aim at maximal and prolonged viral suppression to the lowest possible hepatitis B virus DNA levels. Nucleotide/nucleoside analogues will become the mainstay of treatment. Future treatment strategic plans should target maximising antiviral potency and minimising the chance of drug resistance. © 2006 Informa UK Ltd. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Informa Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/eop | en_HK |
dc.relation.ispartof | Expert Opinion on Pharmacotherapy | en_HK |
dc.rights | Expert Opinion on Pharmacotherapy. Copyright © Informa Healthcare. | en_HK |
dc.subject | Alanine aminotransferase | - |
dc.subject | Chronic hepatitis B | - |
dc.subject | HBeAg seroconversion | - |
dc.subject | HBV DNA | - |
dc.subject | Hepatitis B virus | - |
dc.subject | Interferon | - |
dc.subject | Nucleoside analogue | - |
dc.subject | Nucleotide analogue | - |
dc.subject.mesh | Asia - epidemiology | en_HK |
dc.subject.mesh | Europe - epidemiology | en_HK |
dc.subject.mesh | Forecasting | en_HK |
dc.subject.mesh | Hepatitis B, Chronic - drug therapy - epidemiology - immunology - virology | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Societies, Medical | en_HK |
dc.subject.mesh | United States - epidemiology | en_HK |
dc.title | Recommendations and potential future options in the treatment of hepatitis B | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1465-6566&volume=7&issue=16&spage=2225&epage=2231&date=2006&atitle=Recommendations+and+Potential+Future+Options+in+the+Treatment+of+Hepatitis+B | en_HK |
dc.identifier.email | Yuen, MF:mfyuen@hkucc.hku.hk | en_HK |
dc.identifier.email | Lai, CL:hrmelcl@hku.hk | en_HK |
dc.identifier.authority | Yuen, MF=rp00479 | en_HK |
dc.identifier.authority | Lai, CL=rp00314 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1517/14656566.7.16.2225 | en_HK |
dc.identifier.pmid | 17059379 | en_HK |
dc.identifier.scopus | eid_2-s2.0-39049185674 | en_HK |
dc.identifier.hkuros | 130678 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-39049185674&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 7 | en_HK |
dc.identifier.issue | 16 | en_HK |
dc.identifier.spage | 2225 | en_HK |
dc.identifier.epage | 2231 | en_HK |
dc.identifier.isi | WOS:000241643900004 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Yuen, MF=7102031955 | en_HK |
dc.identifier.scopusauthorid | Lai, CL=7403086396 | en_HK |
dc.identifier.citeulike | 916146 | - |
dc.identifier.issnl | 1465-6566 | - |