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Article: PIN1 expression contributes to hepatic carcinogenesis

TitlePIN1 expression contributes to hepatic carcinogenesis
Authors
Keywordsβ-catenin
Hepatocellular carcinoma
Peptidyl-prolyl-isomerase
PIN1
RNA interference
Issue Date2006
PublisherJohn Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130
Citation
Journal Of Pathology, 2006, v. 210 n. 1, p. 19-25 How to Cite?
AbstractThe phospho-Ser/Thr-Pro specific prolyl-isomerase PIN1 is over-expressed in more than 50% of hepatocellular carcinomas (HCCs). To investigate its potential oncogenicity, we over-expressed PIN1 in a non-transformed human liver cell line MIHA. This resulted in up-regulation of β-catenin and cyclin D1, leading to anchorage-independent growth in soft agar and tumorigenicity in nude mice. To further validate the role of PIN1 in hepatocarcinogenesis, PIN was suppressed by RNA interference (siRNA) in the HCC cell line PLC/PRF/5. siRNA-PIN1 transfection of PLC/ PRF/5 cells led to repression of PIN1 expression, resulting in decreased levels of β-catenin and cyclin D1. siRNA-PIN1 transfectants showed lower cell proliferation rates, reduced colony formation, and retarded cell cycle progression, with an increase in cells residing in G0/G1. Furthermore, soft agar colony formation was depressed, and tumorigenicity in nude mice was abrogated. These findings implicate PIN1 expression as an important step in hepatic carcinogenesis. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/78454
ISSN
2015 Impact Factor: 7.381
2015 SCImago Journal Rankings: 4.176
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPang, RWen_HK
dc.contributor.authorLee, TKen_HK
dc.contributor.authorMan, Ken_HK
dc.contributor.authorPoon, RTen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorTse, Een_HK
dc.date.accessioned2010-09-06T07:43:04Z-
dc.date.available2010-09-06T07:43:04Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Pathology, 2006, v. 210 n. 1, p. 19-25en_HK
dc.identifier.issn0022-3417en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78454-
dc.description.abstractThe phospho-Ser/Thr-Pro specific prolyl-isomerase PIN1 is over-expressed in more than 50% of hepatocellular carcinomas (HCCs). To investigate its potential oncogenicity, we over-expressed PIN1 in a non-transformed human liver cell line MIHA. This resulted in up-regulation of β-catenin and cyclin D1, leading to anchorage-independent growth in soft agar and tumorigenicity in nude mice. To further validate the role of PIN1 in hepatocarcinogenesis, PIN was suppressed by RNA interference (siRNA) in the HCC cell line PLC/PRF/5. siRNA-PIN1 transfection of PLC/ PRF/5 cells led to repression of PIN1 expression, resulting in decreased levels of β-catenin and cyclin D1. siRNA-PIN1 transfectants showed lower cell proliferation rates, reduced colony formation, and retarded cell cycle progression, with an increase in cells residing in G0/G1. Furthermore, soft agar colony formation was depressed, and tumorigenicity in nude mice was abrogated. These findings implicate PIN1 expression as an important step in hepatic carcinogenesis. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130en_HK
dc.relation.ispartofJournal of Pathologyen_HK
dc.rightsJournal of Pathology. Copyright © John Wiley & Sons Ltd.en_HK
dc.subjectβ-cateninen_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectPeptidyl-prolyl-isomeraseen_HK
dc.subjectPIN1en_HK
dc.subjectRNA interferenceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCarcinoma, Hepatocellular - geneticsen_HK
dc.subject.meshCell Lineen_HK
dc.subject.meshCell Line, Tumoren_HK
dc.subject.meshCyclin D1 - geneticsen_HK
dc.subject.meshGene Expression Regulation, Neoplastic - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Neoplasms - geneticsen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Nudeen_HK
dc.subject.meshNeoplasm Proteins - geneticsen_HK
dc.subject.meshPeptidylprolyl Isomerase - geneticsen_HK
dc.subject.meshRNA Interferenceen_HK
dc.subject.meshRNA, Neoplasm - geneticsen_HK
dc.subject.meshTransfection - methodsen_HK
dc.subject.meshUp-Regulation - geneticsen_HK
dc.subject.meshbeta Catenin - geneticsen_HK
dc.titlePIN1 expression contributes to hepatic carcinogenesisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3417&volume=210&issue=1&spage=19&epage=25&date=2006&atitle=PIN1+expression+contributes+to+hepatic+carcinogenesisen_HK
dc.identifier.emailPang, RW: robertap@hkucc.hku.hken_HK
dc.identifier.emailLee, TK: tkwlee@hkucc.hku.hken_HK
dc.identifier.emailMan, K: kwanman@hkucc.hku.hken_HK
dc.identifier.emailPoon, RT: poontp@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailKwong, YL: ylkwong@hku.hken_HK
dc.identifier.emailTse, E: ewctse@hku.hken_HK
dc.identifier.authorityPang, RW=rp00274en_HK
dc.identifier.authorityLee, TK=rp00447en_HK
dc.identifier.authorityMan, K=rp00417en_HK
dc.identifier.authorityPoon, RT=rp00446en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityTse, E=rp00471en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/path.2024en_HK
dc.identifier.pmid16841372-
dc.identifier.scopuseid_2-s2.0-33747874514en_HK
dc.identifier.hkuros119928en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33747874514&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume210en_HK
dc.identifier.issue1en_HK
dc.identifier.spage19en_HK
dc.identifier.epage25en_HK
dc.identifier.isiWOS:000240040800004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridPang, RW=7004376659en_HK
dc.identifier.scopusauthoridLee, TK=7501439435en_HK
dc.identifier.scopusauthoridMan, K=7101754072en_HK
dc.identifier.scopusauthoridPoon, RT=7103097223en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridTse, E=7005019454en_HK

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