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Article: Bioavailable testosterone is associated with a reduced risk of amnestic mild cognitive impairment in older men

TitleBioavailable testosterone is associated with a reduced risk of amnestic mild cognitive impairment in older men
Authors
Issue Date2008
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664
Citation
Clinical Endocrinology, 2008, v. 68 n. 4, p. 589-598 How to Cite?
AbstractObjective: We investigated the risk of amnestic mild cognitive impairment (aMCI) in relation to serum bioavailable (BT) and total testosterone (TT) levels in older men. Design, setting and subjects: A cross-sectional study in an ambulatory setting, with older men aged 55-93 years with normal cognition, aMCI and Alzheimer's disease (AD). Measurements: Morning serum BT and TT levels were determined. AD was diagnosed by the Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria for probable AD and aMCI by the Petersen criteria. Results: We recruited 203 Chinese older men (48 aMCI, 66 AD and 89 with normal cognition). Mean serum BT, but not TT, levels were significantly lower in the aMCI (mean BT ± SEM 1.06 ± 0.10 nmol/l) and AD (0.99 ± 0.08 nmol/l) groups than in the normal controls (1.82 ± 0.12 nmol/l) (P < 0.001, one-way anova) with no significant difference between the aMCI and AD groups. After adjustment for education, age and apolipoprotein E (apoE) genotype, logistic regression analyses showed that the serum BT level [adjusted odds ratio (OR) = 0.52, 95% confidence interval (CI) 0.32-0.85] was an independent protective factor for aMCI. For the combined outcome of aMCI and AD, the serum BT level was an independent protective factor but age and apoE ε4 were independent risk factors. There was no interaction between BT and age. Conclusions: In older men, serum BT, but not TT, levels were associated with a lower risk of aMCI and AD. © 2007 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/78444
ISSN
2015 Impact Factor: 3.487
2015 SCImago Journal Rankings: 1.314
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChu, LWen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorLee, PWHen_HK
dc.contributor.authorWong, RLCen_HK
dc.contributor.authorYik, PYen_HK
dc.contributor.authorTsui, Wen_HK
dc.contributor.authorSong, Yen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorMorley, JEen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-09-06T07:42:58Z-
dc.date.available2010-09-06T07:42:58Z-
dc.date.issued2008en_HK
dc.identifier.citationClinical Endocrinology, 2008, v. 68 n. 4, p. 589-598en_HK
dc.identifier.issn0300-0664en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78444-
dc.description.abstractObjective: We investigated the risk of amnestic mild cognitive impairment (aMCI) in relation to serum bioavailable (BT) and total testosterone (TT) levels in older men. Design, setting and subjects: A cross-sectional study in an ambulatory setting, with older men aged 55-93 years with normal cognition, aMCI and Alzheimer's disease (AD). Measurements: Morning serum BT and TT levels were determined. AD was diagnosed by the Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria for probable AD and aMCI by the Petersen criteria. Results: We recruited 203 Chinese older men (48 aMCI, 66 AD and 89 with normal cognition). Mean serum BT, but not TT, levels were significantly lower in the aMCI (mean BT ± SEM 1.06 ± 0.10 nmol/l) and AD (0.99 ± 0.08 nmol/l) groups than in the normal controls (1.82 ± 0.12 nmol/l) (P < 0.001, one-way anova) with no significant difference between the aMCI and AD groups. After adjustment for education, age and apolipoprotein E (apoE) genotype, logistic regression analyses showed that the serum BT level [adjusted odds ratio (OR) = 0.52, 95% confidence interval (CI) 0.32-0.85] was an independent protective factor for aMCI. For the combined outcome of aMCI and AD, the serum BT level was an independent protective factor but age and apoE ε4 were independent risk factors. There was no interaction between BT and age. Conclusions: In older men, serum BT, but not TT, levels were associated with a lower risk of aMCI and AD. © 2007 The Authors.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664en_HK
dc.relation.ispartofClinical Endocrinologyen_HK
dc.rightsClinical Endocrinology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subject.meshAlzheimer Disease - blood-
dc.subject.meshCognition - physiology-
dc.subject.meshCognition Disorders - blood-
dc.subject.meshTestosterone - blood-
dc.subject.meshAged-
dc.titleBioavailable testosterone is associated with a reduced risk of amnestic mild cognitive impairment in older menen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-0664&volume=68&spage=589&epage=98&date=2008&atitle=Bioavailable+testosterone+is+associated+with+a+reduced+risk+of+amnestic+mild+cognitive+impairment+in+older+menen_HK
dc.identifier.emailSong, Y:songy@hkucc.hku.hken_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.authoritySong, Y=rp00488en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-2265.2007.03094.xen_HK
dc.identifier.pmid17973937-
dc.identifier.scopuseid_2-s2.0-40749154873en_HK
dc.identifier.hkuros142305en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-40749154873&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume68en_HK
dc.identifier.issue4en_HK
dc.identifier.spage589en_HK
dc.identifier.epage598en_HK
dc.identifier.isiWOS:000253977800014-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChu, LW=7202236665en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridLee, PWH=7406120357en_HK
dc.identifier.scopusauthoridWong, RLC=26434054000en_HK
dc.identifier.scopusauthoridYik, PY=15060623700en_HK
dc.identifier.scopusauthoridTsui, W=7005623160en_HK
dc.identifier.scopusauthoridSong, Y=7404921212en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridMorley, JE=7403144221en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.citeulike2540837-

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