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Article: Pathogenesis of lupus nephritis: An update

TitlePathogenesis of lupus nephritis: An update
Authors
KeywordsApoptosis
Autoantibody
Complement
Lupus nephritis
Nitric oxide
Nucleosome
Pathogenesis
Superoxide
Issue Date2005
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NEP
Citation
Nephrology, 2005, v. 10 n. 2, p. 174-179 How to Cite?
AbstractLupus nephritis (LN) is a prototypic autoimmune disease. Its immunopathogenesis is characterized by the loss of self-tolerance. In this article, we review our current understanding of the disease mediators of LN. There is ample evidence to suggest a pathogenic role of nephritogenic autoantibodies. These antibodies cross react with nucleosomal epitopes, and the in vivo generation of nucleosomes requires apoptosis. Furthermore, there is an intriguing and paradoxical relationship between complement and systemic lupus erythematosus (SLE). Immune complex-mediated activation of complement through the classic pathway is traditionally believed to be a major mechanism by which tissue injury occurs. In contrast, hereditary deficiencies of complement components increase the risk of SLE. Finally, the roles of reactive nitrogen and oxygen species are emphasized. © 2005 Asian Pacific Society of Nephrology.
Persistent Identifierhttp://hdl.handle.net/10722/78331
ISSN
2015 Impact Factor: 1.796
2015 SCImago Journal Rankings: 0.894
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, Sen_HK
dc.contributor.authorLui, SLen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2010-09-06T07:41:42Z-
dc.date.available2010-09-06T07:41:42Z-
dc.date.issued2005en_HK
dc.identifier.citationNephrology, 2005, v. 10 n. 2, p. 174-179en_HK
dc.identifier.issn1320-5358en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78331-
dc.description.abstractLupus nephritis (LN) is a prototypic autoimmune disease. Its immunopathogenesis is characterized by the loss of self-tolerance. In this article, we review our current understanding of the disease mediators of LN. There is ample evidence to suggest a pathogenic role of nephritogenic autoantibodies. These antibodies cross react with nucleosomal epitopes, and the in vivo generation of nucleosomes requires apoptosis. Furthermore, there is an intriguing and paradoxical relationship between complement and systemic lupus erythematosus (SLE). Immune complex-mediated activation of complement through the classic pathway is traditionally believed to be a major mechanism by which tissue injury occurs. In contrast, hereditary deficiencies of complement components increase the risk of SLE. Finally, the roles of reactive nitrogen and oxygen species are emphasized. © 2005 Asian Pacific Society of Nephrology.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NEPen_HK
dc.relation.ispartofNephrologyen_HK
dc.subjectApoptosisen_HK
dc.subjectAutoantibodyen_HK
dc.subjectComplementen_HK
dc.subjectLupus nephritisen_HK
dc.subjectNitric oxideen_HK
dc.subjectNucleosomeen_HK
dc.subjectPathogenesisen_HK
dc.subjectSuperoxideen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshApoptosisen_HK
dc.subject.meshAutoantibodies - immunologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLupus Nephritis - etiology - immunology - metabolismen_HK
dc.subject.meshSuperoxides - metabolismen_HK
dc.titlePathogenesis of lupus nephritis: An updateen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1320-5358&volume=10&spage=174&epage=179&date=2005&atitle=Pathogenesis+of+lupus+nephritis:+an+updateen_HK
dc.identifier.emailTang, S: scwtang@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityTang, S=rp00480en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1797.2005.00392.xen_HK
dc.identifier.pmid15877678-
dc.identifier.scopuseid_2-s2.0-20144375468en_HK
dc.identifier.hkuros100099en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20144375468&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue2en_HK
dc.identifier.spage174en_HK
dc.identifier.epage179en_HK
dc.identifier.isiWOS:000228866700015-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridTang, S=7403437082en_HK
dc.identifier.scopusauthoridLui, SL=7102379130en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.citeulike180500-

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