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Article: The effect of radioiodine treatment of hyperthyroidism on plasma apolipoprotein(a) concentrations and phenotypic expression

TitleThe effect of radioiodine treatment of hyperthyroidism on plasma apolipoprotein(a) concentrations and phenotypic expression
Authors
Issue Date1997
Citation
Endocrinology And Metabolism, 1997, v. 4 n. 6, p. 353-360 How to Cite?
AbstractPlasma apolipoprotein(a) concentrations are influenced by genetic factors, particularly Kringle IV polymorphism, and non-genetic factors including thyroid hormones. While plasma apo(a) concentrations are increased even in subclinical hypothyroidism, and low plasma concentrations present in hyperthyroidism increase after treatment, it is unclear whether there are differential or parallel effects on apo(a) isoforms of different size. We investigated this using high resolution apo(a) phenotyping. In 30 hyperthyroid patients, plasma apo(a) concentrations increased after radioiodine treatment, mean 78.6 (range 17-458) U/I at baseline vs 132.3 (17- 1078) U/I at 3 months (P<0.001). In five subjects with transient hypothyroidism, plasma apo(a) increased further, while in 11 patients with recurrent hyperthyroidism, 6 months post treatment plasma apo(a) concentrations declined again. High resolution SDS-agarose gel electrophoresis used to define apo(a) KIV size phenotypes showed 14 different isoforms ranging from KIV 16 to KIV 37. Two isoforms were present in 57% of patients. During treatment, changes in apo(a) isoforms paralleled those of plasma apo(a) concentrations and affected both large (KIV 29-37) and small (KIV 16-25) isoforms. In patients with two isoforms, both changed in parallel. Rises in plasma apo(a) concentrations lagged behind LDL cholesterol rises. This suggests that the thyroxine effects on plasma apo(a) concentrations are unlikely to be mediated via effects on the LDL receptor, which affect predominantly LDL catabolism. In conclusion, plasma apo(a) concentrations increased during treatment of hyperthyroidism, but more slowly than LDL. This effect on apo(a) applied to all apo(a) isoforms, large and small, with changes occurring in parallel rather than differentially when two isoforms were present in any one individual.
Persistent Identifierhttp://hdl.handle.net/10722/78305
ISSN
1999 Impact Factor: 0.716
2015 SCImago Journal Rankings: 0.497
References

 

DC FieldValueLanguage
dc.contributor.authorJanus, EDen_HK
dc.contributor.authorPang, RWCen_HK
dc.contributor.authorChua, DTen_HK
dc.contributor.authorYau, CCen_HK
dc.contributor.authorKung, AWCen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-09-06T07:41:25Z-
dc.date.available2010-09-06T07:41:25Z-
dc.date.issued1997en_HK
dc.identifier.citationEndocrinology And Metabolism, 1997, v. 4 n. 6, p. 353-360en_HK
dc.identifier.issn1074-939Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/78305-
dc.description.abstractPlasma apolipoprotein(a) concentrations are influenced by genetic factors, particularly Kringle IV polymorphism, and non-genetic factors including thyroid hormones. While plasma apo(a) concentrations are increased even in subclinical hypothyroidism, and low plasma concentrations present in hyperthyroidism increase after treatment, it is unclear whether there are differential or parallel effects on apo(a) isoforms of different size. We investigated this using high resolution apo(a) phenotyping. In 30 hyperthyroid patients, plasma apo(a) concentrations increased after radioiodine treatment, mean 78.6 (range 17-458) U/I at baseline vs 132.3 (17- 1078) U/I at 3 months (P<0.001). In five subjects with transient hypothyroidism, plasma apo(a) increased further, while in 11 patients with recurrent hyperthyroidism, 6 months post treatment plasma apo(a) concentrations declined again. High resolution SDS-agarose gel electrophoresis used to define apo(a) KIV size phenotypes showed 14 different isoforms ranging from KIV 16 to KIV 37. Two isoforms were present in 57% of patients. During treatment, changes in apo(a) isoforms paralleled those of plasma apo(a) concentrations and affected both large (KIV 29-37) and small (KIV 16-25) isoforms. In patients with two isoforms, both changed in parallel. Rises in plasma apo(a) concentrations lagged behind LDL cholesterol rises. This suggests that the thyroxine effects on plasma apo(a) concentrations are unlikely to be mediated via effects on the LDL receptor, which affect predominantly LDL catabolism. In conclusion, plasma apo(a) concentrations increased during treatment of hyperthyroidism, but more slowly than LDL. This effect on apo(a) applied to all apo(a) isoforms, large and small, with changes occurring in parallel rather than differentially when two isoforms were present in any one individual.en_HK
dc.languageengen_HK
dc.relation.ispartofEndocrinology and Metabolismen_HK
dc.titleThe effect of radioiodine treatment of hyperthyroidism on plasma apolipoprotein(a) concentrations and phenotypic expressionen_HK
dc.typeArticleen_HK
dc.identifier.emailPang, RWC: robertap@hku.hken_HK
dc.identifier.emailChua, DT: dttchua@hkucc.hku.hken_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityPang, RWC=rp00274en_HK
dc.identifier.authorityChua, DT=rp00415en_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-0031467853en_HK
dc.identifier.hkuros33570en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031467853&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume4en_HK
dc.identifier.issue6en_HK
dc.identifier.spage353en_HK
dc.identifier.epage360en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK
dc.identifier.scopusauthoridPang, RWC=7004376659en_HK
dc.identifier.scopusauthoridChua, DT=7006773480en_HK
dc.identifier.scopusauthoridYau, CC=7007038422en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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