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Article: Transcatheter arterial chemoembolization in inoperable hepatocellular carcinoma: four-year follow-up

TitleTranscatheter arterial chemoembolization in inoperable hepatocellular carcinoma: four-year follow-up
Authors
Issue Date1996
PublisherLippincott Williams & Wilkins, Ltd. The Journal's web site is located at http://www.jvir.org/
Citation
Journal of Vascular and Interventional Radiology, 1996, v. 7 n. 3, p. 419-425 How to Cite?
AbstractPURPOSE: To evaluate the efficacy of repeated chemoembolization in patients with inoperable hepatocellular carcinoma (HCC). PATIENTS AND METHODS: One hundred thirty-two patients with HCC underwent transcatheter arterial chemoembolization with an emulsion of iodized oil and cisplatin. In 104 patients, 'light' gelatin sponge embolization was also used. Chemoembolization was repeated every 1.5-3.0 months in most patients (range, one to 18 chemoembolization sessions). RESULTS: In 74 patients, the HCCs became smaller or disappeared after chemoembolization. Decreases in size were seen in 55 of 76 HCCs 9 cm or smaller, 17 of 42 HCCs between 9 and 18 cm, and two of 14 HCCs larger than 18 cm. Use of gelatin sponge pledgets enhanced the response in tumors larger than 9 cm. Seven of 74 HCCs that responded to chemoembolization increased in size later. New daughter nodules that appeared at other sites responded to chemoembolization in 24 of 40 patients. Further new nodules appeared in 14 of 24 patients, and in six patients they responded to therapy. Median survival was 26 months for patients with responsive HCCs and 5 months for those with unresponsive lesions. CONCLUSION: Tumor size at the start of chemoembolization influenced the response to treatment and survival. The addition of gelatin sponge improved results only in tumors larger than 9 cm. Recurrence after an initial response was due more to the appearance of new daughter nodules in new locations rather than recrudescence of the presenting tumor.
Persistent Identifierhttp://hdl.handle.net/10722/78301
ISSN
2015 Impact Factor: 2.57
2015 SCImago Journal Rankings: 1.210
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNgan, Hen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorLai, ECen_HK
dc.contributor.authorYuen, WKen_HK
dc.contributor.authorTso, WKen_HK
dc.date.accessioned2010-09-06T07:41:22Z-
dc.date.available2010-09-06T07:41:22Z-
dc.date.issued1996en_HK
dc.identifier.citationJournal of Vascular and Interventional Radiology, 1996, v. 7 n. 3, p. 419-425en_HK
dc.identifier.issn1051-0443en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78301-
dc.description.abstractPURPOSE: To evaluate the efficacy of repeated chemoembolization in patients with inoperable hepatocellular carcinoma (HCC). PATIENTS AND METHODS: One hundred thirty-two patients with HCC underwent transcatheter arterial chemoembolization with an emulsion of iodized oil and cisplatin. In 104 patients, 'light' gelatin sponge embolization was also used. Chemoembolization was repeated every 1.5-3.0 months in most patients (range, one to 18 chemoembolization sessions). RESULTS: In 74 patients, the HCCs became smaller or disappeared after chemoembolization. Decreases in size were seen in 55 of 76 HCCs 9 cm or smaller, 17 of 42 HCCs between 9 and 18 cm, and two of 14 HCCs larger than 18 cm. Use of gelatin sponge pledgets enhanced the response in tumors larger than 9 cm. Seven of 74 HCCs that responded to chemoembolization increased in size later. New daughter nodules that appeared at other sites responded to chemoembolization in 24 of 40 patients. Further new nodules appeared in 14 of 24 patients, and in six patients they responded to therapy. Median survival was 26 months for patients with responsive HCCs and 5 months for those with unresponsive lesions. CONCLUSION: Tumor size at the start of chemoembolization influenced the response to treatment and survival. The addition of gelatin sponge improved results only in tumors larger than 9 cm. Recurrence after an initial response was due more to the appearance of new daughter nodules in new locations rather than recrudescence of the presenting tumor.-
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins, Ltd. The Journal's web site is located at http://www.jvir.org/en_HK
dc.relation.ispartofJournal of Vascular and Interventional Radiologyen_HK
dc.rightsJournal of Vascular and Interventional Radiology. Copyright © Lippincott Williams & Wilkins, Ltd.en_HK
dc.subject.meshAntineoplastic Agents - administration and dosage-
dc.subject.meshCarcinoma, Hepatocellular - blood supply - mortality - therapy-
dc.subject.meshChemoembolization, Therapeutic - methods-
dc.subject.meshIodized Oil - administration and dosage-
dc.subject.meshLiver Neoplasms - blood supply - mortality - therapy-
dc.titleTranscatheter arterial chemoembolization in inoperable hepatocellular carcinoma: four-year follow-upen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1051-0443&volume=7&spage=419&epage=425&date=1996&atitle=Transcatheter+arterial+chemoembolization+in+inoperable+hepatocellular+carcinoma:+a+4-year+follow-upen_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailLai, EC: ecslai@HKUCC.hku.hken_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.doi10.1016/S1051-0443(96)72881-6-
dc.identifier.pmid8761824-
dc.identifier.scopuseid_2-s2.0-0030137390-
dc.identifier.hkuros13124en_HK
dc.identifier.hkuros22903-
dc.identifier.volume7-
dc.identifier.issue3-
dc.identifier.spage419-
dc.identifier.epage425-
dc.identifier.isiWOS:A1996UQ43900021-
dc.publisher.placeUnited States-
dc.customcontrol.immutablejt 130710-

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