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Article: Incidence and pathology of primary brain lymphoma in Hong Kong Chinese patients

TitleIncidence and pathology of primary brain lymphoma in Hong Kong Chinese patients
Authors
Keywordsbcl-2
bcl-6
Chinese
EBV
Primary brain lymphoma
Issue Date2000
PublisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lal
Citation
Leukemia And Lymphoma, 2000, v. 37 n. 1-2, p. 175-179 How to Cite?
AbstractPrimary brain lymphoma (PBL) is an uncommon extranodal lymphoma. Its incidence is rapidly increasing in both immunocompromised and immunocompetent patients in Western countries. Eighteen cases of PBL were identified during a 16-year period among HIV negative patients in Queen Mary Hospital, Hong Kong. One case of post-transplantation lymphoproliferative disease (PTLD) was positive for Epstein Barr virus (EBV) encoded RNA (EBER) by in situ hybridization. All the remaining 17 immunocompetent cases were classified as diffuse large B-cell lymphoma, except for one case of Burkitt's lymphoma. EBER expression was negative in all 13 cases tested. Immunostaining for bcl-2 and bcl-6 was positive in 8/11 and 6/11 cases tested, with heterogeneous combination of expression and intensity. The incidence rate of PBL in immunocompetent patients was stable at 1.03 per million per year. The incidence of PBL in post transplantation (0.16%) and HIV related setting (0.29%) is also low in Chinese. PBL in Chinese patients is almost uniformly represented by EBV negative, diffuse large B-cell lymphoma, confined to the brain. However, the molecular pathogenesis may be heterogeneous.
Persistent Identifierhttp://hdl.handle.net/10722/78158
ISSN
2015 Impact Factor: 3.093
2015 SCImago Journal Rankings: 1.202
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorChan, ACLen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorLiang, Ren_HK
dc.date.accessioned2010-09-06T07:39:48Z-
dc.date.available2010-09-06T07:39:48Z-
dc.date.issued2000en_HK
dc.identifier.citationLeukemia And Lymphoma, 2000, v. 37 n. 1-2, p. 175-179en_HK
dc.identifier.issn1042-8194en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78158-
dc.description.abstractPrimary brain lymphoma (PBL) is an uncommon extranodal lymphoma. Its incidence is rapidly increasing in both immunocompromised and immunocompetent patients in Western countries. Eighteen cases of PBL were identified during a 16-year period among HIV negative patients in Queen Mary Hospital, Hong Kong. One case of post-transplantation lymphoproliferative disease (PTLD) was positive for Epstein Barr virus (EBV) encoded RNA (EBER) by in situ hybridization. All the remaining 17 immunocompetent cases were classified as diffuse large B-cell lymphoma, except for one case of Burkitt's lymphoma. EBER expression was negative in all 13 cases tested. Immunostaining for bcl-2 and bcl-6 was positive in 8/11 and 6/11 cases tested, with heterogeneous combination of expression and intensity. The incidence rate of PBL in immunocompetent patients was stable at 1.03 per million per year. The incidence of PBL in post transplantation (0.16%) and HIV related setting (0.29%) is also low in Chinese. PBL in Chinese patients is almost uniformly represented by EBV negative, diffuse large B-cell lymphoma, confined to the brain. However, the molecular pathogenesis may be heterogeneous.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lalen_HK
dc.relation.ispartofLeukemia and Lymphomaen_HK
dc.rightsLeukemia and Lymphoma. Copyright © Informa Healthcare.en_HK
dc.subjectbcl-2en_HK
dc.subjectbcl-6en_HK
dc.subjectChineseen_HK
dc.subjectEBVen_HK
dc.subjectPrimary brain lymphomaen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAsian Continental Ancestry Groupen_HK
dc.subject.meshBrain Neoplasms - epidemiology - metabolism - pathologyen_HK
dc.subject.meshDNA-Binding Proteinsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHerpesvirus 4, Humanen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIncidenceen_HK
dc.subject.meshLymphoma - epidemiology - metabolism - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshProto-Oncogene Proteinsen_HK
dc.subject.meshProto-Oncogene Proteins c-bcl-2en_HK
dc.subject.meshProto-Oncogene Proteins c-bcl-6en_HK
dc.subject.meshTranscription Factorsen_HK
dc.titleIncidence and pathology of primary brain lymphoma in Hong Kong Chinese patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1042-8194&volume=37&spage=175&epage=179&date=2000&atitle=Incidence+and+pathology+of+primary+brain+lymphoma+in+Hong+Kong+Chinese+patientsen_HK
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_HK
dc.identifier.emailLeung, SY:suetyi@hkucc.hku.hken_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10721783-
dc.identifier.scopuseid_2-s2.0-0034092657en_HK
dc.identifier.hkuros50234en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034092657&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage175en_HK
dc.identifier.epage179en_HK
dc.identifier.isiWOS:000085706200018-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridChan, ACL=16047349300en_HK
dc.identifier.scopusauthoridSrivastava, G=7202242238en_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK

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