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Article: Serum adipocyte fatty acid-binding protein levels were independently associated with carotid atherosclerosis

TitleSerum adipocyte fatty acid-binding protein levels were independently associated with carotid atherosclerosis
Authors
KeywordsAdipocyte fatty acid-binding protein
Atherosclerosis
Carotid intima-media thickness
Chinese
Obesity
Issue Date2007
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.lww.com/product/?1079-5642
Citation
Arteriosclerosis, Thrombosis, And Vascular Biology, 2007, v. 27 n. 8, p. 1796-1802 How to Cite?
AbstractOBJECTIVE - Adipocyte fatty acid-binding protein (A-FABP) has been shown to be an important player in atherosclerosis in animal models. However, the clinical relevance of these findings is still unknown. This study aims to examine the relationship between serum A-FABP level and carotid intima-media thickness (IMT), an indicator of atherosclerosis in humans. METHODS AND RESULTS - The study cohort included 479 Chinese subjects who underwent carotid IMT measurement. Serum A-FABP levels were determined by enzyme-linked immunosorbent assays. Serum A-FABP levels positively correlated with carotid IMT in both men (r=0.211, P=0.001) and women (r=0.435, P<0.001). In women, but not in men, the presence of plaques was associated with significantly higher serum A-FABP levels (P<0.001 versus women without plaques). Stepwise multiple regression analysis showed that serum A-FABP level was independently associated with carotid IMT in women (P=0.034), together with age and hypertension (both P<0.001). CONCLUSIONS - A-FABP is an independent determinant of carotid atherosclerosis in Chinese women, but not in men. This gender difference may be attributed to the lower serum A-FABP levels in men, and the effect of other risk factors, such as smoking, among our male participants. Our results have provided clinical evidence supporting the role of A-FABP in the development of atherosclerosis. © 2007 American Heart Association, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/78086
ISSN
2015 Impact Factor: 5.969
2015 SCImago Journal Rankings: 3.356
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYeung, DCYen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorCheung, CWSen_HK
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorYau, MHen_HK
dc.contributor.authorFong, CHYen_HK
dc.contributor.authorChau, MTen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-09-06T07:39:01Z-
dc.date.available2010-09-06T07:39:01Z-
dc.date.issued2007en_HK
dc.identifier.citationArteriosclerosis, Thrombosis, And Vascular Biology, 2007, v. 27 n. 8, p. 1796-1802en_HK
dc.identifier.issn1079-5642en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78086-
dc.description.abstractOBJECTIVE - Adipocyte fatty acid-binding protein (A-FABP) has been shown to be an important player in atherosclerosis in animal models. However, the clinical relevance of these findings is still unknown. This study aims to examine the relationship between serum A-FABP level and carotid intima-media thickness (IMT), an indicator of atherosclerosis in humans. METHODS AND RESULTS - The study cohort included 479 Chinese subjects who underwent carotid IMT measurement. Serum A-FABP levels were determined by enzyme-linked immunosorbent assays. Serum A-FABP levels positively correlated with carotid IMT in both men (r=0.211, P=0.001) and women (r=0.435, P<0.001). In women, but not in men, the presence of plaques was associated with significantly higher serum A-FABP levels (P<0.001 versus women without plaques). Stepwise multiple regression analysis showed that serum A-FABP level was independently associated with carotid IMT in women (P=0.034), together with age and hypertension (both P<0.001). CONCLUSIONS - A-FABP is an independent determinant of carotid atherosclerosis in Chinese women, but not in men. This gender difference may be attributed to the lower serum A-FABP levels in men, and the effect of other risk factors, such as smoking, among our male participants. Our results have provided clinical evidence supporting the role of A-FABP in the development of atherosclerosis. © 2007 American Heart Association, Inc.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.lww.com/product/?1079-5642en_HK
dc.relation.ispartofArteriosclerosis, Thrombosis, and Vascular Biologyen_HK
dc.rightsArteriosclerosis, Thrombosis, and Vascular Biology. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subjectAdipocyte fatty acid-binding proteinen_HK
dc.subjectAtherosclerosisen_HK
dc.subjectCarotid intima-media thicknessen_HK
dc.subjectChineseen_HK
dc.subjectObesityen_HK
dc.titleSerum adipocyte fatty acid-binding protein levels were independently associated with carotid atherosclerosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1079-5642&volume=27&spage=1796&epage=1802&date=2007&atitle=Serum+Adipocyte+Fatty+Acid-Binding+Protein+Levels+Were+Independently+Associated+With+Carotid+Atherosclerosisen_HK
dc.identifier.emailXu, A:amxu@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1161/ATVBAHA.107.146274en_HK
dc.identifier.scopuseid_2-s2.0-34547612970en_HK
dc.identifier.hkuros131946en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547612970&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1796en_HK
dc.identifier.epage1802en_HK
dc.identifier.isiWOS:000248176200019-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYeung, DCY=36869426200en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridCheung, CWS=36569919200en_HK
dc.identifier.scopusauthoridWat, NMS=6602131754en_HK
dc.identifier.scopusauthoridYau, MH=9233223900en_HK
dc.identifier.scopusauthoridFong, CHY=14033917100en_HK
dc.identifier.scopusauthoridChau, MT=7006073758en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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