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Article: Necrotizing fasciitis in rheumatic diseases

TitleNecrotizing fasciitis in rheumatic diseases
Authors
KeywordsImmunocompromised hosts, β-haemolytic streptococcus
Infection
Issue Date2006
PublisherSage Publications Ltd. The Journal's web site is located at http://lup.sagepub.com
Citation
Lupus, 2006, v. 15 n. 6, p. 380-383 How to Cite?
AbstractNecrotizing fasciitis is an uncommon but life-threatening complication in immunocompromised hosts. We reported four patients with rheumatic diseases complicated by necrotizing fasciitis and reviewed 14 others from literature search. Most patients were on corticosteroid treatment. Septic shock, disseminated intravascular coagulopathy and acute renal deterioration were common giving rise to an overall mortality rate of 27.8%. Septic arthritis may also complicate the condition. Statistical analysis on the series showed the lack of major surgical debridement as the only risk factor associated with increased mortality (RR 7.5, 95% CI 2.1-27.3, P = 0.01). Timely debridement of necrotic tissue is important for reducing mortality. © 2006 Edward Arnold (Publishers) Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/78059
ISSN
2015 Impact Factor: 2.118
2015 SCImago Journal Rankings: 0.878
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMok, MYen_HK
dc.contributor.authorWong, SYen_HK
dc.contributor.authorChan, TMen_HK
dc.contributor.authorTang, WMen_HK
dc.contributor.authorWong, WSen_HK
dc.contributor.authorLau, CSen_HK
dc.date.accessioned2010-09-06T07:38:43Z-
dc.date.available2010-09-06T07:38:43Z-
dc.date.issued2006en_HK
dc.identifier.citationLupus, 2006, v. 15 n. 6, p. 380-383en_HK
dc.identifier.issn0961-2033en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78059-
dc.description.abstractNecrotizing fasciitis is an uncommon but life-threatening complication in immunocompromised hosts. We reported four patients with rheumatic diseases complicated by necrotizing fasciitis and reviewed 14 others from literature search. Most patients were on corticosteroid treatment. Septic shock, disseminated intravascular coagulopathy and acute renal deterioration were common giving rise to an overall mortality rate of 27.8%. Septic arthritis may also complicate the condition. Statistical analysis on the series showed the lack of major surgical debridement as the only risk factor associated with increased mortality (RR 7.5, 95% CI 2.1-27.3, P = 0.01). Timely debridement of necrotic tissue is important for reducing mortality. © 2006 Edward Arnold (Publishers) Ltd.en_HK
dc.languageengen_HK
dc.publisherSage Publications Ltd. The Journal's web site is located at http://lup.sagepub.comen_HK
dc.relation.ispartofLupusen_HK
dc.rightsLupus. Copyright © Sage Publications Ltd.en_HK
dc.subjectImmunocompromised hosts, β-haemolytic streptococcusen_HK
dc.subjectInfectionen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAeromonas - isolation & purificationen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnti-Bacterial Agents - therapeutic useen_HK
dc.subject.meshArthritis, Infectious - etiologyen_HK
dc.subject.meshArthritis, Rheumatoid - complications - drug therapyen_HK
dc.subject.meshArthroplasty, Replacement, Hipen_HK
dc.subject.meshCombined Modality Therapyen_HK
dc.subject.meshCyclophosphamide - adverse effects - therapeutic useen_HK
dc.subject.meshDebridementen_HK
dc.subject.meshDisseminated Intravascular Coagulation - etiologyen_HK
dc.subject.meshFasciitis, Necrotizing - drug therapy - etiology - surgeryen_HK
dc.subject.meshFatal Outcomeen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFemur Head Necrosis - chemically induced - surgeryen_HK
dc.subject.meshFishes - microbiologyen_HK
dc.subject.meshGram-Negative Bacterial Infections - drug therapy - etiology - surgeryen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunocompromised Hosten_HK
dc.subject.meshImmunosuppressive Agents - adverse effects - therapeutic useen_HK
dc.subject.meshLupus Erythematosus, Systemic - complications - drug therapyen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPrednisolone - adverse effects - therapeutic useen_HK
dc.subject.meshPseudomonas Infections - drug therapy - etiology - surgeryen_HK
dc.subject.meshScleroderma, Diffuse - complications - drug therapyen_HK
dc.subject.meshShock, Septic - etiologyen_HK
dc.subject.meshSkin - injuriesen_HK
dc.subject.meshSkin Transplantationen_HK
dc.subject.meshStreptococcal Infections - drug therapy - etiology - surgeryen_HK
dc.subject.meshSurgical Wound Infection - etiologyen_HK
dc.titleNecrotizing fasciitis in rheumatic diseasesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0961-2033&volume=15&spage=380&epage=383&date=2006&atitle=Necrotizing+fasciitis+in+rheumatic+diseases.en_HK
dc.identifier.emailMok, MY:temy@hkucc.hku.hken_HK
dc.identifier.emailWong, SY:samsonsy@hkucc.hku.hken_HK
dc.identifier.emailChan, TM:dtmchan@hku.hken_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.authorityMok, MY=rp00490en_HK
dc.identifier.authorityWong, SY=rp00395en_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1191/0961203306lu2314cren_HK
dc.identifier.pmid16830885-
dc.identifier.scopuseid_2-s2.0-33745840509en_HK
dc.identifier.hkuros134389en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745840509&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue6en_HK
dc.identifier.spage380en_HK
dc.identifier.epage383en_HK
dc.identifier.isiWOS:000238439800009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMok, MY=7006024184en_HK
dc.identifier.scopusauthoridWong, SY=13310021400en_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK
dc.identifier.scopusauthoridTang, WM=7403430820en_HK
dc.identifier.scopusauthoridWong, WS=8737892100en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.citeulike697678-

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