File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Unusual endocrine presentations of nasopharyngeal carcinoma
  • Basic View
  • Metadata View
  • XML View
TitleUnusual endocrine presentations of nasopharyngeal carcinoma
 
AuthorsTan, KCB1 2
Nicholls, J1
Kung, AWC1
Leong, L1
Lam, KSL1
 
Keywordsbone metastases
ectopic ACTH syndrome
Epstein- Barr virus
nasopharyngeal carcinoma
 
Issue Date1996
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
 
CitationCancer, 1996, v. 77 n. 10, p. 1967-1972 [How to Cite?]
DOI: http://dx.doi.org/10.1002/(SICI)1097-0142(19960515)77:10<1967::AID-CNCR1>3.0.CO;2-E
 
AbstractBACKGROUND. Nasopharyngeal carcinoma is endemic in Southern China and the majority of patients present with local symptoms due to the tumor. METHODS. This report describes two unusual cases of occult nasopharyngeal carcinoma in which the patients initially presented with endocrine manifestations. RESULTS. The first patient presented with Cushing's syndrome secondary to ectopic adrenocorticotropic hormone (ACTH) production. Nasolaryngoscopy showed a growth in the left nasal fossa and biopsy revealed a poorly differentiated nasopharyngeal carcinoma that exhibited positive immunostaining for ACTH. The second patient presented with a 10-month history of bone pain over both lower limbs. She was normocalcemic but her serum alkaline phosphatase was markedly elevated. A bone biopsy showed both osteoclastic and osteoblastic activity with widespread fibrosis suggestive of Paget's disease. Three months later, she developed third cranial nerve palsy. Computed tomography investigation revealed a soft tissue mass filling the sphenoid and ethmoid sinuses. Biopsy showed a poorly differentiated nasopharyngeal carcinoma. The bone biopsy was reviewed and immunohistochemistry demonstrated the presence of cells positive for the epithelial marker AE1/3 within the fibrous stroma. Radio-labeled in situ hybridization showed that Epstein-Barr virus early RNA was present in these tumor cells and the bone lesions were in fact metastases. CONCLUSIONS. Nasopharyngeal carcinoma can present with rather atypical symptoms that may lead to a delay in diagnosis. Therefore, in high risk populations, it is important to consider nasopharyngeal carcinoma as a possible primary tumor in patients with occult carcinomas.
 
ISSN0008-543X
2013 Impact Factor: 4.901
 
DOIhttp://dx.doi.org/10.1002/(SICI)1097-0142(19960515)77:10<1967::AID-CNCR1>3.0.CO;2-E
 
ISI Accession Number IDWOS:A1996UJ26200001
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTan, KCB
 
dc.contributor.authorNicholls, J
 
dc.contributor.authorKung, AWC
 
dc.contributor.authorLeong, L
 
dc.contributor.authorLam, KSL
 
dc.date.accessioned2010-09-06T07:38:00Z
 
dc.date.available2010-09-06T07:38:00Z
 
dc.date.issued1996
 
dc.description.abstractBACKGROUND. Nasopharyngeal carcinoma is endemic in Southern China and the majority of patients present with local symptoms due to the tumor. METHODS. This report describes two unusual cases of occult nasopharyngeal carcinoma in which the patients initially presented with endocrine manifestations. RESULTS. The first patient presented with Cushing's syndrome secondary to ectopic adrenocorticotropic hormone (ACTH) production. Nasolaryngoscopy showed a growth in the left nasal fossa and biopsy revealed a poorly differentiated nasopharyngeal carcinoma that exhibited positive immunostaining for ACTH. The second patient presented with a 10-month history of bone pain over both lower limbs. She was normocalcemic but her serum alkaline phosphatase was markedly elevated. A bone biopsy showed both osteoclastic and osteoblastic activity with widespread fibrosis suggestive of Paget's disease. Three months later, she developed third cranial nerve palsy. Computed tomography investigation revealed a soft tissue mass filling the sphenoid and ethmoid sinuses. Biopsy showed a poorly differentiated nasopharyngeal carcinoma. The bone biopsy was reviewed and immunohistochemistry demonstrated the presence of cells positive for the epithelial marker AE1/3 within the fibrous stroma. Radio-labeled in situ hybridization showed that Epstein-Barr virus early RNA was present in these tumor cells and the bone lesions were in fact metastases. CONCLUSIONS. Nasopharyngeal carcinoma can present with rather atypical symptoms that may lead to a delay in diagnosis. Therefore, in high risk populations, it is important to consider nasopharyngeal carcinoma as a possible primary tumor in patients with occult carcinomas.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationCancer, 1996, v. 77 n. 10, p. 1967-1972 [How to Cite?]
DOI: http://dx.doi.org/10.1002/(SICI)1097-0142(19960515)77:10<1967::AID-CNCR1>3.0.CO;2-E
 
dc.identifier.doihttp://dx.doi.org/10.1002/(SICI)1097-0142(19960515)77:10<1967::AID-CNCR1>3.0.CO;2-E
 
dc.identifier.epage1972
 
dc.identifier.hkuros14142
 
dc.identifier.isiWOS:A1996UJ26200001
 
dc.identifier.issn0008-543X
2013 Impact Factor: 4.901
 
dc.identifier.issue10
 
dc.identifier.openurl
 
dc.identifier.pmid8640657
 
dc.identifier.scopuseid_2-s2.0-0029880192
 
dc.identifier.spage1967
 
dc.identifier.urihttp://hdl.handle.net/10722/77994
 
dc.identifier.volume77
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
 
dc.publisher.placeUnited States
 
dc.relation.ispartofCancer
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.
 
dc.subject.meshACTH Syndrome, Ectopic - complications - diagnosis
 
dc.subject.meshAdrenocorticotropic Hormone - analysis
 
dc.subject.meshBone Neoplasms - secondary
 
dc.subject.meshCushing Syndrome - etiology
 
dc.subject.meshDiagnosis, Differential
 
dc.subject.meshFemale
 
dc.subject.meshHerpesvirus 4, Human - isolation & purification
 
dc.subject.meshHumans
 
dc.subject.meshMiddle Aged
 
dc.subject.meshNasopharyngeal Neoplasms - complications - diagnosis
 
dc.subject.meshOsteitis Deformans - diagnosis
 
dc.subject.meshOsteosclerosis - diagnosis
 
dc.subjectbone metastases
 
dc.subjectectopic ACTH syndrome
 
dc.subjectEpstein- Barr virus
 
dc.subjectnasopharyngeal carcinoma
 
dc.titleUnusual endocrine presentations of nasopharyngeal carcinoma
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Tan, KCB</contributor.author>
<contributor.author>Nicholls, J</contributor.author>
<contributor.author>Kung, AWC</contributor.author>
<contributor.author>Leong, L</contributor.author>
<contributor.author>Lam, KSL</contributor.author>
<date.accessioned>2010-09-06T07:38:00Z</date.accessioned>
<date.available>2010-09-06T07:38:00Z</date.available>
<date.issued>1996</date.issued>
<identifier.citation>Cancer, 1996, v. 77 n. 10, p. 1967-1972</identifier.citation>
<identifier.issn>0008-543X</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/77994</identifier.uri>
<description.abstract>BACKGROUND. Nasopharyngeal carcinoma is endemic in Southern China and the majority of patients present with local symptoms due to the tumor. METHODS. This report describes two unusual cases of occult nasopharyngeal carcinoma in which the patients initially presented with endocrine manifestations. RESULTS. The first patient presented with Cushing&apos;s syndrome secondary to ectopic adrenocorticotropic hormone (ACTH) production. Nasolaryngoscopy showed a growth in the left nasal fossa and biopsy revealed a poorly differentiated nasopharyngeal carcinoma that exhibited positive immunostaining for ACTH. The second patient presented with a 10-month history of bone pain over both lower limbs. She was normocalcemic but her serum alkaline phosphatase was markedly elevated. A bone biopsy showed both osteoclastic and osteoblastic activity with widespread fibrosis suggestive of Paget&apos;s disease. Three months later, she developed third cranial nerve palsy. Computed tomography investigation revealed a soft tissue mass filling the sphenoid and ethmoid sinuses. Biopsy showed a poorly differentiated nasopharyngeal carcinoma. The bone biopsy was reviewed and immunohistochemistry demonstrated the presence of cells positive for the epithelial marker AE1/3 within the fibrous stroma. Radio-labeled in situ hybridization showed that Epstein-Barr virus early RNA was present in these tumor cells and the bone lesions were in fact metastases. CONCLUSIONS. Nasopharyngeal carcinoma can present with rather atypical symptoms that may lead to a delay in diagnosis. Therefore, in high risk populations, it is important to consider nasopharyngeal carcinoma as a possible primary tumor in patients with occult carcinomas.</description.abstract>
<language>eng</language>
<publisher>John Wiley &amp; Sons, Inc. The Journal&apos;s web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741</publisher>
<relation.ispartof>Cancer</relation.ispartof>
<rights>Cancer. Copyright &#169; John Wiley &amp; Sons, Inc.</rights>
<subject>bone metastases</subject>
<subject>ectopic ACTH syndrome</subject>
<subject>Epstein- Barr virus</subject>
<subject>nasopharyngeal carcinoma</subject>
<subject.mesh>ACTH Syndrome, Ectopic - complications - diagnosis</subject.mesh>
<subject.mesh>Adrenocorticotropic Hormone - analysis</subject.mesh>
<subject.mesh>Bone Neoplasms - secondary</subject.mesh>
<subject.mesh>Cushing Syndrome - etiology</subject.mesh>
<subject.mesh>Diagnosis, Differential</subject.mesh>
<subject.mesh>Female</subject.mesh>
<subject.mesh>Herpesvirus 4, Human - isolation &amp; purification</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Middle Aged</subject.mesh>
<subject.mesh>Nasopharyngeal Neoplasms - complications - diagnosis</subject.mesh>
<subject.mesh>Osteitis Deformans - diagnosis</subject.mesh>
<subject.mesh>Osteosclerosis - diagnosis</subject.mesh>
<title>Unusual endocrine presentations of nasopharyngeal carcinoma</title>
<type>Article</type>
<identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=0008-543X&amp;volume=77&amp;issue=10&amp;spage=1967&amp;epage=1972&amp;date=1996&amp;atitle=Unusual+endocrine+presentations+of+nasopharyngeal+carcinoma</identifier.openurl>
<description.nature>link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1002/(SICI)1097-0142(19960515)77:10&lt;1967::AID-CNCR1&gt;3.0.CO;2-E</identifier.doi>
<identifier.pmid>8640657</identifier.pmid>
<identifier.scopus>eid_2-s2.0-0029880192</identifier.scopus>
<identifier.hkuros>14142</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-0029880192&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>77</identifier.volume>
<identifier.issue>10</identifier.issue>
<identifier.spage>1967</identifier.spage>
<identifier.epage>1972</identifier.epage>
<identifier.isi>WOS:A1996UJ26200001</identifier.isi>
<publisher.place>United States</publisher.place>
</item>
Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong