Article: Unusual endocrine presentations of nasopharyngeal carcinoma

File Download

No File Attached
The HKU Scholars Hub has contact details for these author(s).

Links for fulltext
(May Require Subscription)

Publisher Website: 10.1002/(SICI)1097-0142(19960515)77:10<1967::AID-CNCR1>3.0.CO;2-E
Scopus: eid_2-s2.0-0029880192
PMID: 8640657
Find via

Supplementary

Citations:
- Scopus:
- Web of Science:
- PubMed Central:
Item Statistics (The Hub)
Appears in Collections:
- Medicine: Journal/Magazine Articles
- Pathology: Conference papers

Title	Unusual endocrine presentations of nasopharyngeal carcinoma
Authors	Tan, KCB1 2 Nicholls, J1 Kung, AWC1 Leong, L1 Lam, KSL1
Keywords	bone metastases ectopic ACTH syndrome Epstein- Barr virus nasopharyngeal carcinoma
Issue Date	1996
Publisher	John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation	Cancer, 1996, v. 77 n. 10, p. 1967-1972 [How to Cite?] DOI: http://dx.doi.org/10.1002/(SICI)1097-0142(19960515)77:10<1967::AID-CNCR1>3.0.CO;2-E
Abstract	BACKGROUND. Nasopharyngeal carcinoma is endemic in Southern China and the majority of patients present with local symptoms due to the tumor. METHODS. This report describes two unusual cases of occult nasopharyngeal carcinoma in which the patients initially presented with endocrine manifestations. RESULTS. The first patient presented with Cushing's syndrome secondary to ectopic adrenocorticotropic hormone (ACTH) production. Nasolaryngoscopy showed a growth in the left nasal fossa and biopsy revealed a poorly differentiated nasopharyngeal carcinoma that exhibited positive immunostaining for ACTH. The second patient presented with a 10-month history of bone pain over both lower limbs. She was normocalcemic but her serum alkaline phosphatase was markedly elevated. A bone biopsy showed both osteoclastic and osteoblastic activity with widespread fibrosis suggestive of Paget's disease. Three months later, she developed third cranial nerve palsy. Computed tomography investigation revealed a soft tissue mass filling the sphenoid and ethmoid sinuses. Biopsy showed a poorly differentiated nasopharyngeal carcinoma. The bone biopsy was reviewed and immunohistochemistry demonstrated the presence of cells positive for the epithelial marker AE1/3 within the fibrous stroma. Radio-labeled in situ hybridization showed that Epstein-Barr virus early RNA was present in these tumor cells and the bone lesions were in fact metastases. CONCLUSIONS. Nasopharyngeal carcinoma can present with rather atypical symptoms that may lead to a delay in diagnosis. Therefore, in high risk populations, it is important to consider nasopharyngeal carcinoma as a possible primary tumor in patients with occult carcinomas.
ISSN	0008-543X 2011 Impact Factor: 4.771 2011 SCImago Journal Rankings: 0.578
DOI	http://dx.doi.org/10.1002/(SICI)1097-0142(19960515)77:10<1967::AID-CNCR1>3.0.CO;2-E
ISI Accession Number ID	WOS:A1996UJ26200001
References	References in Scopus

DC Field	Value
dc.contributor.author	Tan, KCB
dc.contributor.author	Nicholls, J
dc.contributor.author	Kung, AWC
dc.contributor.author	Leong, L
dc.contributor.author	Lam, KSL
dc.date.accessioned	2010-09-06T07:38:00Z
dc.date.available	2010-09-06T07:38:00Z
dc.date.issued	1996
dc.description.abstract	BACKGROUND. Nasopharyngeal carcinoma is endemic in Southern China and the majority of patients present with local symptoms due to the tumor. METHODS. This report describes two unusual cases of occult nasopharyngeal carcinoma in which the patients initially presented with endocrine manifestations. RESULTS. The first patient presented with Cushing's syndrome secondary to ectopic adrenocorticotropic hormone (ACTH) production. Nasolaryngoscopy showed a growth in the left nasal fossa and biopsy revealed a poorly differentiated nasopharyngeal carcinoma that exhibited positive immunostaining for ACTH. The second patient presented with a 10-month history of bone pain over both lower limbs. She was normocalcemic but her serum alkaline phosphatase was markedly elevated. A bone biopsy showed both osteoclastic and osteoblastic activity with widespread fibrosis suggestive of Paget's disease. Three months later, she developed third cranial nerve palsy. Computed tomography investigation revealed a soft tissue mass filling the sphenoid and ethmoid sinuses. Biopsy showed a poorly differentiated nasopharyngeal carcinoma. The bone biopsy was reviewed and immunohistochemistry demonstrated the presence of cells positive for the epithelial marker AE1/3 within the fibrous stroma. Radio-labeled in situ hybridization showed that Epstein-Barr virus early RNA was present in these tumor cells and the bone lesions were in fact metastases. CONCLUSIONS. Nasopharyngeal carcinoma can present with rather atypical symptoms that may lead to a delay in diagnosis. Therefore, in high risk populations, it is important to consider nasopharyngeal carcinoma as a possible primary tumor in patients with occult carcinomas.
dc.description.nature	Link_to_subscribed_fulltext
dc.identifier.citation	Cancer, 1996, v. 77 n. 10, p. 1967-1972 [How to Cite?] DOI: http://dx.doi.org/10.1002/(SICI)1097-0142(19960515)77:10<1967::AID-CNCR1>3.0.CO;2-E
dc.identifier.doi	http://dx.doi.org/10.1002/(SICI)1097-0142(19960515)77:10<1967::AID-CNCR1>3.0.CO;2-E
dc.identifier.epage	1972
dc.identifier.hkuros	14142
dc.identifier.isi	WOS:A1996UJ26200001
dc.identifier.issn	0008-543X 2011 Impact Factor: 4.771 2011 SCImago Journal Rankings: 0.578
dc.identifier.issue	10
dc.identifier.openurl
dc.identifier.pmid	8640657
dc.identifier.scopus	eid_2-s2.0-0029880192
dc.identifier.spage	1967
dc.identifier.uri	http://hdl.handle.net/10722/77994
dc.identifier.volume	77
dc.language	eng
dc.publisher	John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
dc.publisher.place	United States
dc.relation.ispartof	Cancer
dc.relation.references	References in Scopus
dc.rights	Cancer. Copyright © John Wiley & Sons, Inc.
dc.subject.mesh	ACTH Syndrome, Ectopic - complications - diagnosis
dc.subject.mesh	Adrenocorticotropic Hormone - analysis
dc.subject.mesh	Bone Neoplasms - secondary
dc.subject.mesh	Cushing Syndrome - etiology
dc.subject.mesh	Diagnosis, Differential
dc.subject.mesh	Female
dc.subject.mesh	Herpesvirus 4, Human - isolation & purification
dc.subject.mesh	Humans
dc.subject.mesh	Middle Aged
dc.subject.mesh	Nasopharyngeal Neoplasms - complications - diagnosis
dc.subject.mesh	Osteitis Deformans - diagnosis
dc.subject.mesh	Osteosclerosis - diagnosis
dc.subject	bone metastases
dc.subject	ectopic ACTH syndrome
dc.subject	Epstein- Barr virus
dc.subject	nasopharyngeal carcinoma
dc.title	Unusual endocrine presentations of nasopharyngeal carcinoma
dc.type	Article

<?xml encoding="utf-8" version="1.0"?><item><contributor.author>Tan, KCB</contributor.author><contributor.author>Nicholls, J</contributor.author><contributor.author>Kung, AWC</contributor.author><contributor.author>Leong, L</contributor.author><contributor.author>Lam, KSL</contributor.author><date.accessioned>2010-09-06T07:38:00Z</date.accessioned><date.available>2010-09-06T07:38:00Z</date.available><date.issued>1996</date.issued><identifier.citation>Cancer, 1996, v. 77 n. 10, p. 1967-1972</identifier.citation><identifier.issn>0008-543X</identifier.issn><identifier.uri>http://hdl.handle.net/10722/77994</identifier.uri><description.abstract>BACKGROUND. Nasopharyngeal carcinoma is endemic in Southern China and the majority of patients present with local symptoms due to the tumor. METHODS. This report describes two unusual cases of occult nasopharyngeal carcinoma in which the patients initially presented with endocrine manifestations. RESULTS. The first patient presented with Cushing&apos;s syndrome secondary to ectopic adrenocorticotropic hormone (ACTH) production. Nasolaryngoscopy showed a growth in the left nasal fossa and biopsy revealed a poorly differentiated nasopharyngeal carcinoma that exhibited positive immunostaining for ACTH. The second patient presented with a 10-month history of bone pain over both lower limbs. She was normocalcemic but her serum alkaline phosphatase was markedly elevated. A bone biopsy showed both osteoclastic and osteoblastic activity with widespread fibrosis suggestive of Paget&apos;s disease. Three months later, she developed third cranial nerve palsy. Computed tomography investigation revealed a soft tissue mass filling the sphenoid and ethmoid sinuses. Biopsy showed a poorly differentiated nasopharyngeal carcinoma. The bone biopsy was reviewed and immunohistochemistry demonstrated the presence of cells positive for the epithelial marker AE1/3 within the fibrous stroma. Radio-labeled in situ hybridization showed that Epstein-Barr virus early RNA was present in these tumor cells and the bone lesions were in fact metastases. CONCLUSIONS. Nasopharyngeal carcinoma can present with rather atypical symptoms that may lead to a delay in diagnosis. Therefore, in high risk populations, it is important to consider nasopharyngeal carcinoma as a possible primary tumor in patients with occult carcinomas.</description.abstract><language>eng</language><publisher>John Wiley &amp; Sons, Inc. The Journal&apos;s web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741</publisher><relation.ispartof>Cancer</relation.ispartof><rights>Cancer. Copyright &#169; John Wiley &amp; Sons, Inc.</rights><subject>bone metastases</subject><subject>ectopic ACTH syndrome</subject><subject>Epstein- Barr virus</subject><subject>nasopharyngeal carcinoma</subject><subject.mesh>ACTH Syndrome, Ectopic - complications - diagnosis</subject.mesh><subject.mesh>Adrenocorticotropic Hormone - analysis</subject.mesh><subject.mesh>Bone Neoplasms - secondary</subject.mesh><subject.mesh>Cushing Syndrome - etiology</subject.mesh><subject.mesh>Diagnosis, Differential</subject.mesh><subject.mesh>Female</subject.mesh><subject.mesh>Herpesvirus 4, Human - isolation &amp; purification</subject.mesh><subject.mesh>Humans</subject.mesh><subject.mesh>Middle Aged</subject.mesh><subject.mesh>Nasopharyngeal Neoplasms - complications - diagnosis</subject.mesh><subject.mesh>Osteitis Deformans - diagnosis</subject.mesh><subject.mesh>Osteosclerosis - diagnosis</subject.mesh><title>Unusual endocrine presentations of nasopharyngeal carcinoma</title><type>Article</type><identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=0008-543X&amp;volume=77&amp;issue=10&amp;spage=1967&amp;epage=1972&amp;date=1996&amp;atitle=Unusual+endocrine+presentations+of+nasopharyngeal+carcinoma</identifier.openurl><description.nature>Link_to_subscribed_fulltext</description.nature><identifier.doi>10.1002/(SICI)1097-0142(19960515)77:10&lt;1967::AID-CNCR1&gt;3.0.CO;2-E</identifier.doi><identifier.pmid>8640657</identifier.pmid><identifier.scopus>eid_2-s2.0-0029880192</identifier.scopus><identifier.hkuros>14142</identifier.hkuros><relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-0029880192&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references><identifier.volume>77</identifier.volume><identifier.issue>10</identifier.issue><identifier.spage>1967</identifier.spage><identifier.epage>1972</identifier.epage><identifier.isi>WOS:A1996UJ26200001</identifier.isi><publisher.place>United States</publisher.place></item>

Author Affiliations

The University of Hong Kong
Queen Mary Hospital Hong Kong

Article: Unusual endocrine presentations of nasopharyngeal carcinoma

The HKU Scholars Hub has contact details for these author(s).