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Article: Female children respond to recombinant hepatitis B vaccine with a higher titre than male

TitleFemale children respond to recombinant hepatitis B vaccine with a higher titre than male
Authors
Issue Date1994
PublisherOxford University Press. The Journal's web site is located at http://tropej.oxfordjournals.org/
Citation
Journal Of Tropical Pediatrics, 1994, v. 40 n. 2, p. 104-107 How to Cite?
AbstractOne-hundred and eighty Chinese children [age range 5 months to 12 years, seronegative for all hepatitis B virus (HBV) markers] of parents seropositive for HBV surface antigen (HBsAg) were randomized to receive doses of either 10 or 20 μg of recombinant yeast-derived HBV vaccine at intervals of 0, 1, and 6 months. Six children defaulted and three other children (1.7 per cent) seroconverted to anti-HBc positivity without detectable HBsAg in the serum. All other children attained an anti-HBs titre of > 10 mlU/ml after three doses. Both 10 and 20 μg/dose regime gave a similar geometric mean titre (GMT) of anti-HBs. Children aged 0-4 responded with a similar titre compared with children aged > 4. Female children responded with a significantly higher GMT than male children and this was due to a high proportion of female children with higher peak titres. No major side-effects were encountered. We conclude that recombinant HB vaccine is highly immunogenic, well tolerated and equally effective with doses of both 10 and 20 μg and that girls responded with a higher anti-HBs titre compared with boys.
Persistent Identifierhttp://hdl.handle.net/10722/77821
ISSN
2015 Impact Factor: 1.059
2015 SCImago Journal Rankings: 0.719
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFang, JWSen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorChung, HTen_HK
dc.contributor.authorWu, PCen_HK
dc.contributor.authorLau, JYNen_HK
dc.date.accessioned2010-09-06T07:36:06Z-
dc.date.available2010-09-06T07:36:06Z-
dc.date.issued1994en_HK
dc.identifier.citationJournal Of Tropical Pediatrics, 1994, v. 40 n. 2, p. 104-107en_HK
dc.identifier.issn0142-6338en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77821-
dc.description.abstractOne-hundred and eighty Chinese children [age range 5 months to 12 years, seronegative for all hepatitis B virus (HBV) markers] of parents seropositive for HBV surface antigen (HBsAg) were randomized to receive doses of either 10 or 20 μg of recombinant yeast-derived HBV vaccine at intervals of 0, 1, and 6 months. Six children defaulted and three other children (1.7 per cent) seroconverted to anti-HBc positivity without detectable HBsAg in the serum. All other children attained an anti-HBs titre of > 10 mlU/ml after three doses. Both 10 and 20 μg/dose regime gave a similar geometric mean titre (GMT) of anti-HBs. Children aged 0-4 responded with a similar titre compared with children aged > 4. Female children responded with a significantly higher GMT than male children and this was due to a high proportion of female children with higher peak titres. No major side-effects were encountered. We conclude that recombinant HB vaccine is highly immunogenic, well tolerated and equally effective with doses of both 10 and 20 μg and that girls responded with a higher anti-HBs titre compared with boys.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://tropej.oxfordjournals.org/en_HK
dc.relation.ispartofJournal of Tropical Pediatricsen_HK
dc.rightsJournal of Tropical Pediatrics. Copyright © Oxford University Press.en_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHepatitis B Vaccines - administration & dosageen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfanten_HK
dc.subject.meshMaleen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshSex Factorsen_HK
dc.subject.meshVaccines, Synthetic - administration & dosageen_HK
dc.titleFemale children respond to recombinant hepatitis B vaccine with a higher titre than maleen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0142-6338&volume=40&spage=104&epage=107&date=1994&atitle=Female+children+respond+to+recombinant+hepatitis+B+vaccine+with+a+higher+titre+than+maleen_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8015023en_HK
dc.identifier.scopuseid_2-s2.0-0028323574en_HK
dc.identifier.hkuros13560en_HK
dc.identifier.volume40en_HK
dc.identifier.issue2en_HK
dc.identifier.spage104en_HK
dc.identifier.epage107en_HK
dc.identifier.isiWOS:A1994NL79800010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridFang, JWS=7402963750en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridChung, HT=8545595200en_HK
dc.identifier.scopusauthoridWu, PC=7403119323en_HK
dc.identifier.scopusauthoridLau, JYN=7402446047en_HK

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