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Article: A comparison of fibrosis progression in chronic liver diseases

TitleA comparison of fibrosis progression in chronic liver diseases
Authors
Issue Date2003
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep
Citation
Journal Of Hepatology, 2003, v. 38 n. 3, p. 257-265 How to Cite?
AbstractBackground/Aims: No study has compared the liver fibrosis progression rates among chronic liver diseases and the risk factors in order to better organize screening strategies. Methods: A total of 4852 patients were retrospectively studied (chronic hepatitis C (HCV) [n = 2313], human immunodeficiency virus (HIV)-HCV co-infection (HIV-HCV [n = 180]), hepatitis B (HBV [n = 777]), alcoholic liver disease (ALD [n = 701]), primary biliary cirrhosis (PBC [n = 406]), genetic hemochromatosis (GH [n = 383]) autoimmune hepatitis (AIH [n = 57]) and delta hepatitis (n = 35). The fibrosis progression rates were estimated from birth and from the date of exposure, when known, to the first biopsy. Results: There were highly significant differences in the rates of fibrosis progression, the most rapid being HIV-HCV co-infection (50% cirrhosis percentile at 52 years of age) and the slowest being PBC (50% cirrhosis percentile at 81 years). There was an acceleration of fibrosis progression with aging. Fibrosis progression was slower in females compared with males for HCV, HBV, GH, and PBC. In contrast, in ALD, the fibrosis progression was more rapid in females. Conclusions: Rates of fibrosis progression differ markedly between the predominant causes of chronic liver disease, and according to age and gender. Patients with HIV-HCV co-infection are at particularly high risk of fibrosis progression. © 2002 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/77816
ISSN
2015 Impact Factor: 10.59
2015 SCImago Journal Rankings: 4.570
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPoynard, Ten_HK
dc.contributor.authorMathurin, Pen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorGuyader, Den_HK
dc.contributor.authorPoupon, Ren_HK
dc.contributor.authorTainturier, MHen_HK
dc.contributor.authorMyers, RPen_HK
dc.contributor.authorMuntenau, Men_HK
dc.contributor.authorRatziu, Ven_HK
dc.contributor.authorManns, Men_HK
dc.contributor.authorVogel, Aen_HK
dc.contributor.authorCapron, Fen_HK
dc.contributor.authorChedid, Aen_HK
dc.contributor.authorBedossa, Pen_HK
dc.date.accessioned2010-09-06T07:36:03Z-
dc.date.available2010-09-06T07:36:03Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Hepatology, 2003, v. 38 n. 3, p. 257-265en_HK
dc.identifier.issn0168-8278en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77816-
dc.description.abstractBackground/Aims: No study has compared the liver fibrosis progression rates among chronic liver diseases and the risk factors in order to better organize screening strategies. Methods: A total of 4852 patients were retrospectively studied (chronic hepatitis C (HCV) [n = 2313], human immunodeficiency virus (HIV)-HCV co-infection (HIV-HCV [n = 180]), hepatitis B (HBV [n = 777]), alcoholic liver disease (ALD [n = 701]), primary biliary cirrhosis (PBC [n = 406]), genetic hemochromatosis (GH [n = 383]) autoimmune hepatitis (AIH [n = 57]) and delta hepatitis (n = 35). The fibrosis progression rates were estimated from birth and from the date of exposure, when known, to the first biopsy. Results: There were highly significant differences in the rates of fibrosis progression, the most rapid being HIV-HCV co-infection (50% cirrhosis percentile at 52 years of age) and the slowest being PBC (50% cirrhosis percentile at 81 years). There was an acceleration of fibrosis progression with aging. Fibrosis progression was slower in females compared with males for HCV, HBV, GH, and PBC. In contrast, in ALD, the fibrosis progression was more rapid in females. Conclusions: Rates of fibrosis progression differ markedly between the predominant causes of chronic liver disease, and according to age and gender. Patients with HIV-HCV co-infection are at particularly high risk of fibrosis progression. © 2002 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhepen_HK
dc.relation.ispartofJournal of Hepatologyen_HK
dc.rightsJournal of Hepatology. Copyright © Elsevier BV.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAlcohol Drinkingen_HK
dc.subject.meshChronic Diseaseen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHIV Infections - complicationsen_HK
dc.subject.meshHepatitis B e Antigens - analysisen_HK
dc.subject.meshHepatitis B, Chronic - complicationsen_HK
dc.subject.meshHepatitis D, Chronic - complicationsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Cirrhosis - etiology - pathology - virologyen_HK
dc.subject.meshLiver Diseases - complications - virologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMultivariate Analysisen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshSex Characteristicsen_HK
dc.titleA comparison of fibrosis progression in chronic liver diseasesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0168-8278&volume=38&spage=257&epage=265&date=2003&atitle=A+Comparison+of+Fibrosis+Progression+in+Chronic+Liver+Diseasesen_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0168-8278(02)00413-0en_HK
dc.identifier.pmid12586290-
dc.identifier.scopuseid_2-s2.0-0037335133en_HK
dc.identifier.hkuros80558en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037335133&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume38en_HK
dc.identifier.issue3en_HK
dc.identifier.spage257en_HK
dc.identifier.epage265en_HK
dc.identifier.isiWOS:000181464500002-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridPoynard, T=7103155394en_HK
dc.identifier.scopusauthoridMathurin, P=7005619900en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridGuyader, D=7005862152en_HK
dc.identifier.scopusauthoridPoupon, R=7101891980en_HK
dc.identifier.scopusauthoridTainturier, MH=6603610523en_HK
dc.identifier.scopusauthoridMyers, RP=35407742800en_HK
dc.identifier.scopusauthoridMuntenau, M=12768259300en_HK
dc.identifier.scopusauthoridRatziu, V=7004350599en_HK
dc.identifier.scopusauthoridManns, M=7202889076en_HK
dc.identifier.scopusauthoridVogel, A=7102618692en_HK
dc.identifier.scopusauthoridCapron, F=7006890049en_HK
dc.identifier.scopusauthoridChedid, A=7003959463en_HK
dc.identifier.scopusauthoridBedossa, P=7103025999en_HK

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