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- Publisher Website: 10.1038/ki.2008.209
- Scopus: eid_2-s2.0-53049094210
- PMID: 18496506
- WOS: WOS:000259681300011
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Article: BMP-7 protects mesangial cells from injury by polymeric IgA
Title | BMP-7 protects mesangial cells from injury by polymeric IgA | ||||||||
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Authors | |||||||||
Keywords | BMP-7 IgAN PPAR-γ Smad6 Smad7 TNF-α | ||||||||
Issue Date | 2008 | ||||||||
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/ki/index.html | ||||||||
Citation | Kidney International, 2008, v. 74 n. 8, p. 1026-1039 How to Cite? | ||||||||
Abstract | Bone morphogenetic protein-7 (BMP-7) is a potential therapeutic agent for acute and chronic renal diseases. Here we found that addition of polymeric IgA, isolated from patients with IgA nephropathy, increased the synthesis of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), transforming growth factor-β (TGF-β) and fibronectin in cultured human mesangial cells, effects blunted by BMP-7. When mesangial cells were cultured with both polymeric IgA and BMP-7 there was an increase in the expression of peroxisome proliferator-activated receptor-γ (PPAR-γ). The activation of NFκB and TNF-α synthesis induced by polymeric IgA or TNF-α were downregulated by BMP-7 or rosiglitazone. BMP-7 inhibited TNF-α release from polymeric IgA-stimulated mesangial cells by activation of PPAR-γ but suppressed TGF-β release by mechanisms independent of PPAR-γ. The expression of inhibitory Smad6 and 7 was increased whereas the expression of active Smad2 and 3 was reduced in these mesangial cells by BMP-7. Our study shows that BMP-7 ameliorates IgA nephropathy-derived polymeric IgA-induced TNF-α and TGF-β synthesis in human mesangial cells through multiple mechanisms involving inhibitory Smads and PPAR-γ. © 2008 International Society of Nephrology. | ||||||||
Persistent Identifier | http://hdl.handle.net/10722/77811 | ||||||||
ISSN | 2023 Impact Factor: 14.8 2023 SCImago Journal Rankings: 3.886 | ||||||||
ISI Accession Number ID |
Funding Information: The study was supported by the Research Grant Committee (Hong Kong) (HKU 7546/05M) and Dr LY Chan was partly supported by L & T Charitable Foundation and the House of INDOCAFE. | ||||||||
References | |||||||||
Grants |
DC Field | Value | Language |
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dc.contributor.author | Chan, WL | en_HK |
dc.contributor.author | Leung, JCK | en_HK |
dc.contributor.author | Chan, LYY | en_HK |
dc.contributor.author | Tam, KY | en_HK |
dc.contributor.author | Tang, SCW | en_HK |
dc.contributor.author | Lai, KN | en_HK |
dc.date.accessioned | 2010-09-06T07:35:59Z | - |
dc.date.available | 2010-09-06T07:35:59Z | - |
dc.date.issued | 2008 | en_HK |
dc.identifier.citation | Kidney International, 2008, v. 74 n. 8, p. 1026-1039 | en_HK |
dc.identifier.issn | 0085-2538 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/77811 | - |
dc.description.abstract | Bone morphogenetic protein-7 (BMP-7) is a potential therapeutic agent for acute and chronic renal diseases. Here we found that addition of polymeric IgA, isolated from patients with IgA nephropathy, increased the synthesis of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), transforming growth factor-β (TGF-β) and fibronectin in cultured human mesangial cells, effects blunted by BMP-7. When mesangial cells were cultured with both polymeric IgA and BMP-7 there was an increase in the expression of peroxisome proliferator-activated receptor-γ (PPAR-γ). The activation of NFκB and TNF-α synthesis induced by polymeric IgA or TNF-α were downregulated by BMP-7 or rosiglitazone. BMP-7 inhibited TNF-α release from polymeric IgA-stimulated mesangial cells by activation of PPAR-γ but suppressed TGF-β release by mechanisms independent of PPAR-γ. The expression of inhibitory Smad6 and 7 was increased whereas the expression of active Smad2 and 3 was reduced in these mesangial cells by BMP-7. Our study shows that BMP-7 ameliorates IgA nephropathy-derived polymeric IgA-induced TNF-α and TGF-β synthesis in human mesangial cells through multiple mechanisms involving inhibitory Smads and PPAR-γ. © 2008 International Society of Nephrology. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/ki/index.html | en_HK |
dc.relation.ispartof | Kidney International | en_HK |
dc.subject | BMP-7 | en_HK |
dc.subject | IgAN | en_HK |
dc.subject | PPAR-γ | en_HK |
dc.subject | Smad6 | en_HK |
dc.subject | Smad7 | en_HK |
dc.subject | TNF-α | en_HK |
dc.subject.mesh | Bone Morphogenetic Protein 7 - physiology | en_HK |
dc.subject.mesh | Cells, Cultured | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Glomerulonephritis, IGA - immunology | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Immunoglobulin A - pharmacology | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Mesangial Cells - cytology - drug effects - metabolism | en_HK |
dc.subject.mesh | PPAR gamma - metabolism | en_HK |
dc.subject.mesh | Smad Proteins - metabolism | en_HK |
dc.subject.mesh | Transforming Growth Factor beta - biosynthesis - drug effects | en_HK |
dc.subject.mesh | Tumor Necrosis Factor-alpha - biosynthesis - drug effects | en_HK |
dc.title | BMP-7 protects mesangial cells from injury by polymeric IgA | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0085-2538&volume=74&spage=1026&epage=39&date=2008&atitle=BMP-7+protects+mesangial+cells+from+injury+by+polymeric+IgA | en_HK |
dc.identifier.email | Leung, JCK: jckleung@hku.hk | en_HK |
dc.identifier.email | Tang, SCW: scwtang@hku.hk | en_HK |
dc.identifier.email | Lai, KN: knlai@hku.hk | en_HK |
dc.identifier.authority | Leung, JCK=rp00448 | en_HK |
dc.identifier.authority | Tang, SCW=rp00480 | en_HK |
dc.identifier.authority | Lai, KN=rp00324 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/ki.2008.209 | en_HK |
dc.identifier.pmid | 18496506 | - |
dc.identifier.scopus | eid_2-s2.0-53049094210 | en_HK |
dc.identifier.hkuros | 143114 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-53049094210&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 74 | en_HK |
dc.identifier.issue | 8 | en_HK |
dc.identifier.spage | 1026 | en_HK |
dc.identifier.epage | 1039 | en_HK |
dc.identifier.isi | WOS:000259681300011 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.relation.project | Is there a reno-protective role of bone morphogenetic protein-7 in IgA nephropathy? | - |
dc.identifier.scopusauthorid | Chan, WL=24333977900 | en_HK |
dc.identifier.scopusauthorid | Leung, JCK=7202180349 | en_HK |
dc.identifier.scopusauthorid | Chan, LYY=55182644100 | en_HK |
dc.identifier.scopusauthorid | Tam, KY=25930206700 | en_HK |
dc.identifier.scopusauthorid | Tang, SCW=7403437082 | en_HK |
dc.identifier.scopusauthorid | Lai, KN=7402135706 | en_HK |
dc.identifier.citeulike | 3385647 | - |
dc.identifier.issnl | 0085-2538 | - |