File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: BMP-7 protects mesangial cells from injury by polymeric IgA

TitleBMP-7 protects mesangial cells from injury by polymeric IgA
Authors
KeywordsBMP-7
IgAN
PPAR-γ
Smad6
Smad7
TNF-α
Issue Date2008
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ki/index.html
Citation
Kidney International, 2008, v. 74 n. 8, p. 1026-1039 How to Cite?
AbstractBone morphogenetic protein-7 (BMP-7) is a potential therapeutic agent for acute and chronic renal diseases. Here we found that addition of polymeric IgA, isolated from patients with IgA nephropathy, increased the synthesis of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), transforming growth factor-β (TGF-β) and fibronectin in cultured human mesangial cells, effects blunted by BMP-7. When mesangial cells were cultured with both polymeric IgA and BMP-7 there was an increase in the expression of peroxisome proliferator-activated receptor-γ (PPAR-γ). The activation of NFκB and TNF-α synthesis induced by polymeric IgA or TNF-α were downregulated by BMP-7 or rosiglitazone. BMP-7 inhibited TNF-α release from polymeric IgA-stimulated mesangial cells by activation of PPAR-γ but suppressed TGF-β release by mechanisms independent of PPAR-γ. The expression of inhibitory Smad6 and 7 was increased whereas the expression of active Smad2 and 3 was reduced in these mesangial cells by BMP-7. Our study shows that BMP-7 ameliorates IgA nephropathy-derived polymeric IgA-induced TNF-α and TGF-β synthesis in human mesangial cells through multiple mechanisms involving inhibitory Smads and PPAR-γ. © 2008 International Society of Nephrology.
Persistent Identifierhttp://hdl.handle.net/10722/77811
ISSN
2015 Impact Factor: 7.683
2015 SCImago Journal Rankings: 3.181
ISI Accession Number ID
Funding AgencyGrant Number
Research Grant Committee (Hong Kong)HKU 7546/05M
L & T Charitable Foundation
House of INDOCAFE
Funding Information:

The study was supported by the Research Grant Committee (Hong Kong) (HKU 7546/05M) and Dr LY Chan was partly supported by L & T Charitable Foundation and the House of INDOCAFE.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorChan, WLen_HK
dc.contributor.authorLeung, JCKen_HK
dc.contributor.authorChan, LYYen_HK
dc.contributor.authorTam, KYen_HK
dc.contributor.authorTang, SCWen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2010-09-06T07:35:59Z-
dc.date.available2010-09-06T07:35:59Z-
dc.date.issued2008en_HK
dc.identifier.citationKidney International, 2008, v. 74 n. 8, p. 1026-1039en_HK
dc.identifier.issn0085-2538en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77811-
dc.description.abstractBone morphogenetic protein-7 (BMP-7) is a potential therapeutic agent for acute and chronic renal diseases. Here we found that addition of polymeric IgA, isolated from patients with IgA nephropathy, increased the synthesis of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), transforming growth factor-β (TGF-β) and fibronectin in cultured human mesangial cells, effects blunted by BMP-7. When mesangial cells were cultured with both polymeric IgA and BMP-7 there was an increase in the expression of peroxisome proliferator-activated receptor-γ (PPAR-γ). The activation of NFκB and TNF-α synthesis induced by polymeric IgA or TNF-α were downregulated by BMP-7 or rosiglitazone. BMP-7 inhibited TNF-α release from polymeric IgA-stimulated mesangial cells by activation of PPAR-γ but suppressed TGF-β release by mechanisms independent of PPAR-γ. The expression of inhibitory Smad6 and 7 was increased whereas the expression of active Smad2 and 3 was reduced in these mesangial cells by BMP-7. Our study shows that BMP-7 ameliorates IgA nephropathy-derived polymeric IgA-induced TNF-α and TGF-β synthesis in human mesangial cells through multiple mechanisms involving inhibitory Smads and PPAR-γ. © 2008 International Society of Nephrology.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ki/index.htmlen_HK
dc.relation.ispartofKidney Internationalen_HK
dc.subjectBMP-7en_HK
dc.subjectIgANen_HK
dc.subjectPPAR-γen_HK
dc.subjectSmad6en_HK
dc.subjectSmad7en_HK
dc.subjectTNF-αen_HK
dc.subject.meshBone Morphogenetic Protein 7 - physiologyen_HK
dc.subject.meshCells, Cultureden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGlomerulonephritis, IGA - immunologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunoglobulin A - pharmacologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMesangial Cells - cytology - drug effects - metabolismen_HK
dc.subject.meshPPAR gamma - metabolismen_HK
dc.subject.meshSmad Proteins - metabolismen_HK
dc.subject.meshTransforming Growth Factor beta - biosynthesis - drug effectsen_HK
dc.subject.meshTumor Necrosis Factor-alpha - biosynthesis - drug effectsen_HK
dc.titleBMP-7 protects mesangial cells from injury by polymeric IgAen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0085-2538&volume=74&spage=1026&epage=39&date=2008&atitle=BMP-7+protects+mesangial+cells+from+injury+by+polymeric+IgAen_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.emailTang, SCW: scwtang@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.identifier.authorityTang, SCW=rp00480en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ki.2008.209en_HK
dc.identifier.pmid18496506-
dc.identifier.scopuseid_2-s2.0-53049094210en_HK
dc.identifier.hkuros143114en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-53049094210&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume74en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1026en_HK
dc.identifier.epage1039en_HK
dc.identifier.isiWOS:000259681300011-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectIs there a reno-protective role of bone morphogenetic protein-7 in IgA nephropathy?-
dc.identifier.scopusauthoridChan, WL=24333977900en_HK
dc.identifier.scopusauthoridLeung, JCK=7202180349en_HK
dc.identifier.scopusauthoridChan, LYY=55182644100en_HK
dc.identifier.scopusauthoridTam, KY=25930206700en_HK
dc.identifier.scopusauthoridTang, SCW=7403437082en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.citeulike3385647-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats