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Article: Wilson's disease with depression and parkinsonism

TitleWilson's disease with depression and parkinsonism
Authors
Issue Date2005
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jocn
Citation
Journal Of Clinical Neuroscience, 2005, v. 12 n. 3, p. 303-305 How to Cite?
AbstractWilson's disease (WD) is an autosomal recessive disorder with reduced biliary excretion of copper plus impaired formation of ceruloplasmin, leading to copper accumulation in the liver, brain, kidney, and cornea. Clinical manifestations include liver damage, psychiatric symptoms, and neurological features. We report a 35-year-old woman with a history of deranged liver functions who had severe depression several years later and eventually presented with parkinsonian features. The underlying diagnosis is WD and family screening revealed WD in 2 other siblings. She could not tolerate penicillamine because of fever and leucopenia. While taking trientine hydrochloride and zinc sulphate, her parkinsonism improved and her depression remained in remission. WD should be considered in patients with unexplained liver function derangement or psychiatric symptoms. Early diagnosis and initiation of specific treatment are crucial in minimising any further cerebral and hepatic damage as well as securing possible improvement in organ functions. © 2004 Published by Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/77798
ISSN
2015 Impact Factor: 1.387
2015 SCImago Journal Rankings: 0.609
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KHen_HK
dc.contributor.authorCheung, RTFen_HK
dc.contributor.authorAuYeung, KMen_HK
dc.contributor.authorMak, Wen_HK
dc.contributor.authorCheng, TSen_HK
dc.contributor.authorHo, SLen_HK
dc.date.accessioned2010-09-06T07:35:51Z-
dc.date.available2010-09-06T07:35:51Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of Clinical Neuroscience, 2005, v. 12 n. 3, p. 303-305en_HK
dc.identifier.issn0967-5868en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77798-
dc.description.abstractWilson's disease (WD) is an autosomal recessive disorder with reduced biliary excretion of copper plus impaired formation of ceruloplasmin, leading to copper accumulation in the liver, brain, kidney, and cornea. Clinical manifestations include liver damage, psychiatric symptoms, and neurological features. We report a 35-year-old woman with a history of deranged liver functions who had severe depression several years later and eventually presented with parkinsonian features. The underlying diagnosis is WD and family screening revealed WD in 2 other siblings. She could not tolerate penicillamine because of fever and leucopenia. While taking trientine hydrochloride and zinc sulphate, her parkinsonism improved and her depression remained in remission. WD should be considered in patients with unexplained liver function derangement or psychiatric symptoms. Early diagnosis and initiation of specific treatment are crucial in minimising any further cerebral and hepatic damage as well as securing possible improvement in organ functions. © 2004 Published by Elsevier Ltd.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jocnen_HK
dc.relation.ispartofJournal of Clinical Neuroscienceen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAntiparkinson Agents - therapeutic useen_HK
dc.subject.meshBrain - pathologyen_HK
dc.subject.meshBromocriptine - therapeutic useen_HK
dc.subject.meshChelating Agents - therapeutic useen_HK
dc.subject.meshDepressive Disorder - complications - pathology - psychologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHepatolenticular Degeneration - complications - pathology - psychologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMagnetic Resonance Imagingen_HK
dc.subject.meshParkinsonian Disorders - complications - pathology - psychologyen_HK
dc.subject.meshPenicillamine - therapeutic useen_HK
dc.subject.meshSuicide, Attempteden_HK
dc.subject.meshTomography, X-Ray Computeden_HK
dc.subject.meshTrientine - therapeutic useen_HK
dc.subject.meshTrihexyphenidyl - therapeutic useen_HK
dc.titleWilson's disease with depression and parkinsonismen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0967-5868&volume=12&issue=3&spage=303&epage=5&date=2005&atitle=Wilson%27s+Disease+With+Depression+And+Parkinsonism.en_HK
dc.identifier.emailCheung, RTF:rtcheung@hku.hken_HK
dc.identifier.emailHo, SL:slho@hku.hken_HK
dc.identifier.authorityCheung, RTF=rp00434en_HK
dc.identifier.authorityHo, SL=rp00240en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jocn.2004.09.005en_HK
dc.identifier.pmid15851088-
dc.identifier.scopuseid_2-s2.0-17844410058en_HK
dc.identifier.hkuros105627en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17844410058&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue3en_HK
dc.identifier.spage303en_HK
dc.identifier.epage305en_HK
dc.identifier.isiWOS:000229383400021-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, KH=7406034963en_HK
dc.identifier.scopusauthoridCheung, RTF=7202397498en_HK
dc.identifier.scopusauthoridAuYeung, KM=6601970562en_HK
dc.identifier.scopusauthoridMak, W=22948344000en_HK
dc.identifier.scopusauthoridCheng, TS=7404082613en_HK
dc.identifier.scopusauthoridHo, SL=25959633500en_HK

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