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Article: Clearance of hepatitis B surface antigen after bone marrow transplantation: Role of adoptive immunity transfer

TitleClearance of hepatitis B surface antigen after bone marrow transplantation: Role of adoptive immunity transfer
Authors
Issue Date1997
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/
Citation
Hepatology, 1997, v. 25 n. 6, p. 1497-1501 How to Cite?
AbstractAdoptive immunity transfer has been reported to be effective in clearing chronic hepatitis B virus (HBV) infection. Two hundred twenty-six patients who received allogeneic bone marrow transplantation (BMT) between May 1990 and September 1995 were screened for hepatitis B markers. Twenty-one patients were hepatitis B surface antigen (HBsAg) positive before BMT. The median follow-up period was 20 months (range, 2-59 months). Two of these patients had sustained clearance of HBV infection after transplantation. Both patients were hepatitis B e antigen (HBeAg)-negative, hepatitis B e antibody (anti- HBe)-positive, and serum HBV DNA-negative (by dot-blot hybridization) before BMT. Both had a flare in the serum alanine transaminase (ALT) level around the time of HBsAg clearance. Sustained clearance of HBsAg was observed in 2 of the 5 patients who received hepatitis B surface antibody (anti-HBs)- positive marrow but in none of the 16 patients who received anti-HBs-negative marrow (P < .05). One additional patient who received anti-HBs-positive marrow had transient HBsAg seroconversion. Among the 18 patients who remained persistently HBsAg-positive after BMT, 3 had HBeAg seroconversion and 3 had reversion to HBeAg positivity. In this study, we found a significant association between clearance of HBV infection and anti-HBs-positive bone marrow donors. Adoptive immunity transfer is effective in clearing HBV from patients with chronic HBV infection.
Persistent Identifierhttp://hdl.handle.net/10722/77779
ISSN
2015 Impact Factor: 11.711
2015 SCImago Journal Rankings: 4.752
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, GKKen_HK
dc.contributor.authorLok, ASFen_HK
dc.contributor.authorLiang, RHSen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorChiu, EKWen_HK
dc.contributor.authorLau, LYen_HK
dc.contributor.authorLam, SKen_HK
dc.date.accessioned2010-09-06T07:35:38Z-
dc.date.available2010-09-06T07:35:38Z-
dc.date.issued1997en_HK
dc.identifier.citationHepatology, 1997, v. 25 n. 6, p. 1497-1501en_HK
dc.identifier.issn0270-9139en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77779-
dc.description.abstractAdoptive immunity transfer has been reported to be effective in clearing chronic hepatitis B virus (HBV) infection. Two hundred twenty-six patients who received allogeneic bone marrow transplantation (BMT) between May 1990 and September 1995 were screened for hepatitis B markers. Twenty-one patients were hepatitis B surface antigen (HBsAg) positive before BMT. The median follow-up period was 20 months (range, 2-59 months). Two of these patients had sustained clearance of HBV infection after transplantation. Both patients were hepatitis B e antigen (HBeAg)-negative, hepatitis B e antibody (anti- HBe)-positive, and serum HBV DNA-negative (by dot-blot hybridization) before BMT. Both had a flare in the serum alanine transaminase (ALT) level around the time of HBsAg clearance. Sustained clearance of HBsAg was observed in 2 of the 5 patients who received hepatitis B surface antibody (anti-HBs)- positive marrow but in none of the 16 patients who received anti-HBs-negative marrow (P < .05). One additional patient who received anti-HBs-positive marrow had transient HBsAg seroconversion. Among the 18 patients who remained persistently HBsAg-positive after BMT, 3 had HBeAg seroconversion and 3 had reversion to HBeAg positivity. In this study, we found a significant association between clearance of HBV infection and anti-HBs-positive bone marrow donors. Adoptive immunity transfer is effective in clearing HBV from patients with chronic HBV infection.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/en_HK
dc.relation.ispartofHepatologyen_HK
dc.rightsHepatology. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdoptive Transferen_HK
dc.subject.meshAdulten_HK
dc.subject.meshBone Marrow - immunologyen_HK
dc.subject.meshBone Marrow Transplantationen_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHepatitis B Antibodies - analysisen_HK
dc.subject.meshHepatitis B Surface Antigens - analysis - immunologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPostoperative Perioden_HK
dc.subject.meshTissue Donorsen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleClearance of hepatitis B surface antigen after bone marrow transplantation: Role of adoptive immunity transferen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0270-9139&volume=25&issue=6&spage=1497&epage=1501&date=1997&atitle=Clearance+of+Hepatitis+B+Surface+Antigen+After+Bone+Marrow+Transplantation:+Role+of+Adoptive+Immunity+Transferen_HK
dc.identifier.emailLiang, RHS:rliang@hku.hken_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.emailLau, LY:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityLiang, RHS=rp00345en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityLau, LY=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hep.510250631en_HK
dc.identifier.pmid9185774-
dc.identifier.scopuseid_2-s2.0-0031005299en_HK
dc.identifier.hkuros23693en_HK
dc.identifier.hkuros33119-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031005299&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1497en_HK
dc.identifier.epage1501en_HK
dc.identifier.isiWOS:A1997XC87200032-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLau, GKK=7102301257en_HK
dc.identifier.scopusauthoridLok, ASF=35379868500en_HK
dc.identifier.scopusauthoridLiang, RHS=26643224900en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridChiu, EKW=24827833600en_HK
dc.identifier.scopusauthoridLau, LY=7201403380en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK

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